salicylates and Foot-Dermatoses

Topics: Anti-Infective Agents; Combined Modality Therapy; Cymbopogon; Debridement; Female; Foot Dermatoses; Humans; Immunocompromised Host; Keratolytic Agents; Lavandula; Mentha piperita; Nonprescription Drugs; Oils, Volatile; Ovarian Neoplasms; Plant Oils; Recurrence; Salicylates; Salicylic Acid; Treatment Outcome; Warts

Thirty-five patients with dermatophyte onychomycosis caused by Trichophyton rubrum, T. mentagrophytes var. granulosum, T. tonsurans and Epidermophyton floccosum were examined before treatment and 27 of these patients were examined again when they came to the control check up 3 months after completion of treatment. The immunological investigations, including evaluation of immunological competence, were performed in vivo through the determination of lymphoid cell immunophenotype by a flow cytometry technique. The quantitative composition of basic lymphocyte subpopulations and natural killer cells in the peripheral blood of 35 patients before the treatment was compared with a control group of 20 individuals. Statistically significant differences in the percentages of CD3+ T lymphocytes (P<0.05), T helper lymphocytes (CD4+) (P<0.05) and activated T lymphocytes (CD3+/HLA-DR+) (P<0.05) were obtained. In the control check-up examinations of 27 patients 3 months after completion of treatment, in comparison with the control group of 20 healthy individuals, highly statistically significant differences in percehtages of T lymphocytes (CD3+) (P<0.001) and T helper lymphocytes (CD4+) (P<0.01) were obtained. In five of these 27 patients the treatment resulted in failure. Comparing the group of 22 recovered patients with these five patients in whom the treatment result was failure, the only statistically significant difference obtained before as well as after the treatment was in B lymphocytes (CD19+) percentage (P<0.05). The results obtained confirm that impairments of the patients' cellular immunity are crucial factors influencing the course and results of treatment in dermatophyte onychomycosis.

Topics: Antifungal Agents; Antigens, CD19; CD3 Complex; CD4 Antigens; Epidermophyton; Foot Dermatoses; Hand Dermatoses; HLA-DR Antigens; Humans; Itraconazole; Killer Cells, Natural; Lymphocyte Count; Lymphocyte Subsets; Naphthalenes; Onychomycosis; Salicylates; Terbinafine; Trichophyton

Xerosis is defined as dehydration of skin characterized by redness, dry scaling, and fine crackling that may resemble the crackling of porcelain. The present double-blind trial was a randomized paired comparison study evaluating the keratolytic effect of 5% salicylic acid and 10% urea ointment (Kerasal) on one foot and 12% ammonium lactate lotion (Lac-Hydrin) on the other foot in mild-to-moderate xerosis. Seventy patients were initially enrolled in the trial. Fifty-four patients were evaluated after 2 weeks of treatment; of those 54 patients, 39 were evaluated after 4 weeks of treatment. Although there was significant improvement in severity of xerosis after 2 and 4 weeks of treatment, there was no statistically significant difference between treatment groups. Irrespective of the mechanism of action, this study shows that both Kerasal and Lac-Hydrin 12% lotion result in reduction in the severity of xerosis after 4 weeks of therapy.

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Dermatologic Agents; Double-Blind Method; Drug Combinations; Foot Dermatoses; Humans; Keratolytic Agents; Lactic Acid; Middle Aged; Propionates; Quaternary Ammonium Compounds; Salicylates; Salicylic Acid; Urea

Topics: Clinical Trials as Topic; Copper; Drug Combinations; Foot Dermatoses; Hand Dermatoses; Humans; Lactic Acid; Plant Extracts; Salicylates; Warts

Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Diagnosis, Differential; Female; Foot Dermatoses; Humans; Nail Diseases; Nails; Onychomycosis; Osteoma, Osteoid; Salicylates; Toes; Young Adult

Ten patients who presented with nonmosaic plantar warts were treated with a new polymeric matrix patch delivery system containing salicylic acid USP, 21 percent. Clinicians then assessed the potential value of this patch system in terms of efficacy, length of treatment time required, patient compliance, and tolerance.

Topics: Administration, Cutaneous; Foot Dermatoses; Humans; Polymers; Salicylates; Salicylic Acid; Warts

Topics: Diflunisal; Female; Foot Dermatoses; Hand Dermatoses; Humans; Lichen Planus; Middle Aged; Photosensitivity Disorders; Salicylates

Topics: Administration, Topical; Adult; Aged; Dichloroacetic Acid; Female; Foot Dermatoses; Hand Dermatoses; Humans; Male; Middle Aged; Nail Diseases; Ointments; Onychomycosis; Salicylates; Sulfur

Topics: Adolescent; Adult; Ambulatory Care; Animals; Bees; Benzoates; Cryosurgery; Dimethyl Sulfoxide; Drug Combinations; Foot Dermatoses; Hand Dermatoses; Humans; Iodine; Lanolin; Middle Aged; Nitrogen; Onychomycosis; Salicylates; Waxes

Topics: Adolescent; Adult; Aged; Antifungal Agents; Dimethyl Sulfoxide; Female; Foot Dermatoses; Hand Dermatoses; Humans; Hydroxyquinolines; Middle Aged; Onychomycosis; Oxyquinoline; Salicylates; Solutions