salicylates and Esophageal-and-Gastric-Varices

We have developed a new method for inducing portal hypertension and esophageal varices in rats--partial ligation of the portal vein after devascularization of the circumference of the left renal vein and complete ligation of the portal vein on the fifth day thereafter. Thirty rats were separated into groups of 10, control (sham operation), complete portal ligation only and complete portal ligation plus devascularization. Two weeks after the surgery, the presence of esophageal varices in rats with complete portal ligation plus devascularization was confirmed by portography and by the histological findings. The diameter (mean +/- SD) of the submucosal veins of the lower esophagus in the complete portal ligation plus devascularization group (219.4 +/- 86.6 microns) was significantly larger than that in the complete portal ligation group (99.8 +/- 53.4 microns) or in the control group (30.5 +/- 16.6 microns) (p less than 0.01). Vascular structures of the lower esophagus closely resembled those in humans with esophageal varices. This new technique is simple, rapid and reliable, and application can be made to various experimental studies on portal hypertension.

Topics: Animals; Blood Pressure; Disease Models, Animal; Esophageal and Gastric Varices; Esophagus; Ligation; Male; Mucous Membrane; Portal System; Portal Vein; Portography; Rats; Rats, Inbred Strains; Renal Veins; Salicylates; Veins

Topics: Adult; Aged; Cortisone; Endoscopy; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis; Male; Middle Aged; Peptic Ulcer Hemorrhage; Phenylbutazone; Renal Dialysis; Salicylates; Sepsis

Four hundred consecutive patients, in a representative Southern California population, hospitalized for upper gastrointestinal hemorrhage, had endoscopic examinations performed within 24 hours of arrival in the emergency room. Seventy-four (18.5 percent) of these were found to have the typical lesions of acute hemorrhagic erosive gastritis. The clinical spectrum of this group is examined and a comparison made with a Veterans Hospital population reported previously.

Topics: Adult; Aged; Duodenal Ulcer; Esophageal and Gastric Varices; Esophagitis; Ethanol; Female; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Salicylates; Sex Ratio; Stomach Ulcer

Topics: Acute Disease; Adult; Anticoagulants; Cortisone; Diagnostic Errors; Drug Synergism; Emergencies; Esophageal and Gastric Varices; Esophagitis; Ethanol; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Peptic Ulcer Hemorrhage; Retrospective Studies; Salicylates

Topics: Adult; Age Factors; Aged; California; Esophageal and Gastric Varices; Ethanol; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Hematemesis; Hematocrit; Hospitalization; Humans; Liver Cirrhosis; Melena; Middle Aged; Peptic Ulcer; Recurrence; Salicylates; Shock, Hemorrhagic

Topics: Alcohol Drinking; Barium Sulfate; Diagnosis, Differential; Esophageal and Gastric Varices; Esophagoscopy; Ethanol; Fiber Optic Technology; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Mallory-Weiss Syndrome; Peptic Ulcer; Radiography; Salicylates; Time Factors

Topics: Adolescent; Biopsy; Child; Child, Preschool; Diet Therapy; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Gold Isotopes; Humans; Hypertension, Portal; Infant; Liver; Liver Circulation; Male; Mercury Isotopes; Portography; Pregnancy; Pregnancy Complications, Hematologic; Radionuclide Imaging; Salicylates