salicylates and Erythema

Topics: Aspirin; Erythema; Erythema Multiforme; Humans; Psoriasis; Purpura; Salicylates; Skin Diseases; Urticaria

Lipohydroxyacid is a lipophilic derivative of salicylic acid with comedolytic properties.. To compare lipohydroxyacid and salicylic acid peels in subjects with comedonal acne.. In this split face, randomized study, 20 subjects with comedonal acne received lipohydroxyacid peels on one side of the face, while the other side was treated with salicylic acid peels. A total of six peels at 2-week intervals were performed. Efficacy was evaluated by counting noninflammatory and inflammatory lesions and by performing a global change in acne assessment. Safety was assessed by evaluating adverse events, global tolerance, and the presence of erythema, scaling, and dryness.. There was a statistically significant decrease of 55.6% and 48.5% from baseline to Day 98 in the mean number of noninflammatory lesions for the sides treated with lipohydroxyacid and salicylic acid peels, respectively (P < 0.001). There was no significant difference in the degree of reduction in noninflammatory lesions between the two peels. There was no significant reduction in the number of inflammatory lesions. Both peels were generally very well tolerated.. This study suggests that lipohydroxyacid peels can be beneficial to subjects with comedonal acne.

Topics: Acne Vulgaris; Administration, Topical; Adult; Chemexfoliation; Erythema; Face; Female; Humans; Keratolytic Agents; Male; Pruritus; Salicylates; Salicylic Acid; Treatment Outcome

Salicylic acid has been widely used in the topical treatment of psoriasis. Chemically it is closely related to paraaminobenzoic acid. Following in vitro studies indicating that salicylic acid might exhibit relevant UVB absorption, we found that salicylic acid had a clinically pronounced filter effect when applied prior to UVB exposure. The duration of photoprotection after application was more than 12 h, sometimes exceeding 24 h. In a prospective, randomized, double-blind, left-right comparison study in patients with psoriasis between emollients with and without salicylic acid, salicylic acid was shown to decrease the clearing rate significantly.

Topics: Administration, Cutaneous; Adult; Aged; Chronic Disease; Double-Blind Method; Emollients; Erythema; Female; Humans; Infant, Newborn; Male; Middle Aged; Prospective Studies; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Therapy

Topics: Administration, Topical; Drug Evaluation; Emollients; Erythema; Humans; Ointment Bases; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Therapy

The relevance of salicylic acid in dithranol creams was evaluated in a double-blind study. Patients with chronic plaque psoriasis were treated using a short-contact schedule for dithranol on an outpatient basis. A left-right comparison was carried out between sites treated with either dithranol with 2% salicylic acid (D + S) or dithranol in the same base without salicylic acid (D-S). Clinical results were evaluated once a week using the psoriasis area severity index. In order to quantify the improvement, flow cytometric measurements were done using the monoclonal antibody Ks8.12, recognizing keratin 16 in normal and lesional epidermis. Simultaneously, relative DNA content was quantified which previously was described as a useful method to monitor a therapeutic effect. Both PASI scores and Ks8.12 binding decreased after 6 weeks treatment with D + S and D-S. However, percentages of cells in SG2M phases did not show a significant change. No significant difference was observed between sites treated with either D + S or D-S. Therefore we conclude that the addition of salicylic acid in a concentration of 2% does not enhance the efficacy of dithranol creams and we confirm that Ks8.12 is a useful quantitative marker for therapeutic efficacy.

Topics: Adolescent; Adult; Anthralin; DNA; Double-Blind Method; Erythema; Female; Flow Cytometry; Humans; Keratins; Male; Middle Aged; Ointments; Psoriasis; Randomized Controlled Trials as Topic; Salicylates; Salicylic Acid; Skin

To determine whether the topical or systemic effects of aspirin are of greater importance in the production of gastroduodenal mucosal damage, the effects of regular and enteric-coated aspirin were compared in 9 healthy volunteers in a 2-week crossover endoscopic study. All subjects developed multiple gastric erosions while taking regular aspirin; 2 subjects developed one gastric erosion each while taking enteric-coated aspirin. 5 subjects developed duodenal erosions while taking regular aspirin, whereas none developed an erosion while taking enteric-coated aspirin. Mean fasting salicylate levels were similar in the two groups. It is concluded that regular aspirin causes a greater amount of gastroduodenal mucosal damage than does enteric-coated aspirin despite similar serum-salicylate levels. This suggests that the topical effects of aspirin are of greater importance than the systemic effects in the production of gastroduodenal mucosal damage in healthy subjects.

Topics: Adult; Aspirin; Duodenal Diseases; Duodenum; Erythema; Gastric Mucosa; Humans; Intestinal Mucosa; Pyloric Antrum; Salicylates; Stomach Diseases; Tablets, Enteric-Coated

Topics: Chronic Disease; Cosmetics; Dermatitis, Allergic Contact; Edema; Erythema; Eyelid Diseases; Facial Dermatoses; Female; Humans; Middle Aged; Pruritus; Salicylates

Melatonin has attracted attention because of their high antioxidant and anticarcinogenic activity. Otherwise, the use of sunscreens is recommended for patients after chemotherapy and radiotherapy treatments or to prevent UV radiation-induced skin damages that may result in pre-cancerous and cancerous skin lesions.. To evaluate the beneficial influence of melatonin in topical sunscreen emulsions combined with three common ultraviolet filters.. After the formulation characterization in terms of rheology, stability studies were performed. Release studies let us to evaluate its mechanism of delivery and ex vivo permeation study through human skin, the amount of melatonin retained. The antioxidant activity assay was also carried out, and finally the in vivo photoprotective effect in rats was tested as transepidermal water loss and erythema formation.. The rheological behaviour of formulations was pseudoplastic fluid, all emulsions had good physical stability. Release studies showed a trend of enhancement in melatonin release from emulsions incorporating UV filters and followed a Weibull model. Melatonin permeation was higher from the emulsion containing melatonin combined with a mixture of three ultraviolet filters (MMIX) formulation. Equally this formulation exhibited the highest radical scavenging activity. Finally the photoprotective assay showed that only skin areas treated with this formulation were statistically equivalent to the unirradiated control area.. MMIX formulation would be a promising formulation for preventing the undesirable adverse effects of UV skin irradiation because melatonin not only acts as a potent antioxidant itself, but also is capable of activating an endogenous enzymatic protective system against oxidative stress.

Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzophenones; Cinnamates; Emulsions; Erythema; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Melatonin; Permeability; Rats; Rats, Wistar; Rheology; Salicylates; Skin; Stress, Mechanical; Sunburn; Sunscreening Agents; Temperature; Ultraviolet Rays

Topics: Anesthesia, Local; Chemexfoliation; Cicatrix; Dermatologic Agents; Dermatologic Surgical Procedures; Drug Combinations; Erythema; Ethanol; Face; Hair Follicle; Humans; Hydroxy Acids; Lactic Acid; Phenols; Pigmentation Disorders; Preoperative Care; Rejuvenation; Resorcinols; Salicylates; Skin Aging; Surgical Wound Infection; Trichloroacetic Acid

Chemical peels are an effective treatment for wrinkles, but their use is limited because of the associated risk of scarring, hypopigmentation, and the inability to accurately control the depth of tissue injury. High energy, pulsed, or computer scanned continuous wave carbon dioxide (CO2) lasers cause minimal thermal injury, decrease the risk of scarring, and allow for precise control of tissue vaporization to predictable depths.. To compare the effectiveness and side effect profile of a medium-depth chemical peel to that of the SilkTouch CO2 laser in the treatment of periorbital wrinkles.. Twenty-four subjects (nine male, 15 female) with moderate to severe periorbital wrinkles were assigned a wrinkle score (1 = mild through 5 = severe) before treatment and 6 months after treatment. Each subject was treated with Jessner's solution and 35% trichloroacetic acid on one side and the SilkTouch CO2 laser on the other side.. The average periorbital wrinkle score decreased from 4.00 +/- 0.78 before laser treatment to 1.75 +/- 0.68 6 months after treatment. The chemical peel wrinkle score decreased from 4.13 +/- 0.85 to 3.29 +/- 0.99. The degree in which the wrinkle score improved after laser treatment compared with after chemical peel treatment was statistically significant. Posttreatment erythema lasted an average of 4.5 months for the laser-treated areas and 2.5 months for the chemical peel-treated areas.. Treatment of periorbital wrinkles with the SilkTouch CO2 laser resulted in a greater degree of improvement than treatment with a medium-depth chemical peel but had longer lasting posttreatment erythema.

Topics: Administration, Cutaneous; Adult; Aged; Carbon Dioxide; Chemexfoliation; Cicatrix; Drug Combinations; Erythema; Ethanol; Female; Fibrosis; Follow-Up Studies; Forecasting; Humans; Hypopigmentation; Lactic Acid; Laser Therapy; Male; Middle Aged; Orbit; Resorcinols; Rhytidoplasty; Risk Factors; Salicylates; Skin; Skin Aging; Time Factors; Trichloroacetic Acid; Wound Healing

Topics: Analysis of Variance; Antirheumatic Agents; Arthritis, Juvenile; Azathioprine; Capillaries; Child; Child, Preschool; Erythema; Glucocorticoids; Humans; Methotrexate; Oxygen; Regression Analysis; Salicylates; Skin; Statistics, Nonparametric

Topics: Adolescent; Antibodies, Viral; Chickenpox; Chickenpox Vaccine; Child; Child, Preschool; Contraindications; Costs and Cost Analysis; Drug Administration Schedule; Erythema; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompromised Host; Infant; Pregnancy; Pregnancy Complications, Infectious; Salicylates; Vaccination; Vaccines, Attenuated; Viral Vaccines

Topical preparations are sometimes applied before phototherapy without consideration of their potential to block UVB.. Our purpose was to examine the ability of topical preparations to block UVB.. Volunteers pretreated with mineral oil, a clear liquid emollient, 5% crude coal tar, 6% salicylic acid ointment, emollient creams, and petrolatum underwent minimal erythema dose testing. Transmission of UVB through a clear film coated with the preparations was measured.. Tars and salicylic acid blocked UVB. Thick application of petrolatum and emollient creams can reduce transmission of UVB. Mineral oil and a clear liquid emollient did not significantly affect transmission or erythemogenicity of UVB.. Clear liquid emollient and mineral oil can be used before phototherapy. If not removed before phototherapy, preparations containing tar or salicylic acid, or thickly applied petrolatum or emollients, can block UVB and presumably reduce its efficacy in the treatment of psoriasis.

Topics: Administration, Cutaneous; Adolescent; Adult; Coal Tar; Emollients; Erythema; Humans; Lipids; Mineral Oil; Ointment Bases; Ointments; Petrolatum; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Rays; Ultraviolet Therapy

To evaluate the efficacy of ultraviolet B (UVB) phototherapy for the treatment of psoriasis in patients infected with human immunodeficiency virus (HIV), the response of 14 patients was compared to that of matched seronegative control individuals. All patients were evaluated prior to treatment (baseline) and after 21 treatments for the extent of total body surface area (TBSA) involvement and the quantification of scale, erythema, and thickness of plaques using a scale of 0 (absent) to 4 (severe). The only concomitant medication allowed was salicylic acid in petrolatum. The cumulative score for scale, erythema, and thickness improved 1.9 +/- 0.5 [mean +/- standard error of mean (SEM)] in the HIV group and 2.4 +/- 0.3 in controls. There was 40.9 +/- 7.3% reduction of TBSA involvement in the former and 38.4 +/- 7.6% reduction in the latter group. None of the differences was statistically significant. There was no statistically significant difference in the response to therapy among various stages of immunosuppression in the HIV group. There was also no deterioration of immune status in this group. UVB phototherapy is an effective treatment for psoriasis in patients infected with HIV. The response is identical to that of matched control individuals.

Topics: Administration, Cutaneous; Adult; Antiviral Agents; Body Surface Area; Case-Control Studies; CD4 Lymphocyte Count; Dermatitis, Exfoliative; Erythema; HIV Infections; HIV Seronegativity; Humans; Immunocompromised Host; Keratolytic Agents; Male; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Rays; Ultraviolet Therapy; Zidovudine

Generalized pruritus in the elderly is a common and distressing problem; often there is no evidence of skin disease other than xerosis.. The aim of the study was to determine whether any abnormality could be detected in the structure and function of the skin of patients with generalized pruritus.. The skin of 13 elderly patients with generalized pruritus, without skin disease or any underlying cause, was contrasted with that of age- and sex-matched normal control subjects.. The patients had clinically drier skin (mean visual analogue scale score 2.9 [standard deviation +/- 2.2], controls 0.52 [+/- 0.59], p = 0.002). The severity of the pruritus was related to the degree of xerosis (r = 0.66). The patients had decreased skin surface conductance (10.7 mumho [+/- 3.4], controls 16 mumho [+/- 5.3], p = 0.017), and increased intracorneal cohesion (240.5 g [+/- 88], controls 162.7 g [+/- 39.8], p = 0.001). The patients also had statistically significantly diminished parameters of skin surface contour.. The findings of increased intracorneal cohesion and altered skin surface contour parameters suggest that elderly patients with generalized pruritus may have an acquired abnormality of keratinization.

Topics: Aged; Aged, 80 and over; Baths; Benzocaine; Circadian Rhythm; Cornea; Drug Combinations; Electric Conductivity; Epidermis; Erythema; Female; Humans; Ichthyosis; Male; Middle Aged; Niacin; Pruritus; Salicylates; Skin; Skin Diseases; Time Factors; Vasodilator Agents

WY-47,288 (2-[(1-naphthalenyloxy)methyl]quinoline) demonstrated topical antiinflammatory activity in several animal models of skin inflammation. Application of WY-47,288 to mouse ear surfaces inhibited arachidonic acid (ED50 = 0.3 mg/ear) and tetradecanoylphorbol acetate (TPA)-induced inflammation (40% at 1 mg/ear). Administration of WY-47,288 (1 mg/ear) at 30 min and 5 h after TPA reduced ear edema and epidermal proliferation by 50%. WY-47,288 also inhibited oxazolone-induced contact hypersensitivity in mouse ears (ED50 = 0.4 mg/ear) and UVB-induced guinea pig skin erythema (ED50 approximately 0.25 mg/spot). These antiinflammatory effects may be due to inhibition of 5-lipoxygenase (5-LO) and cyclooxygenase (CO) since the synthesis of 5-LO and CO products by rat neutrophils and mouse macrophages was dose-dependently reduced by WY-47,288. By contrast, WY-47,288 demonstrated no appreciable inhibition of 12-LO (rabbit platelet), 15-LO (soybean) or phospholipase A2 (human platelet). Furthermore, no systemic adverse effects were observed after topical, parenteral or oral administration of WY-47,288, suggesting that WY-47,288 is a safe topical 5-LO/CO inhibitor for treating skin inflammation.

Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Disease Models, Animal; Ear; Erythema; Female; Guinea Pigs; Inflammation; Lipoxygenase Inhibitors; Mice; Naphthalenes; Quinolines; Radiation Injuries; Salicylates; Skin; Skin Diseases; Tetradecanoylphorbol Acetate; Ultraviolet Rays

Topics: Anthracenes; Anthralin; Coal Tar; Dermatologic Agents; Dose-Response Relationship, Drug; Drug Combinations; Erythema; Humans; Male; Petrolatum; Psoriasis; Salicylates

Topics: Administration, Topical; Animals; Erythema; Radiation Dosage; Radiation Injuries, Experimental; Salicylates; Swine

Topics: Adult; Aged; Anilides; Biopsy; Chlorothiazide; Chlorpromazine; Dermatitis, Contact; Drug Eruptions; Erythema; Female; Halogens; Humans; Male; Middle Aged; Photosensitivity Disorders; Salicylates; Skin; Time Factors; Ultraviolet Rays

Topics: Adult; Alcoholic Intoxication; Barbiturates; Bromides; Coma; Diagnosis, Differential; Diazepam; Erythema; Female; Humans; Male; Salicylates; Skin Manifestations; Substance-Related Disorders

Topics: Adolescent; Adult; Aged; Ampicillin; Analgesics; Anaphylaxis; Angioedema; Anti-Bacterial Agents; Barbiturates; Child; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; Erythema; Exanthema; Female; Humans; Infant; Male; Middle Aged; Penicillins; Photosensitivity Disorders; Salicylates; Stevens-Johnson Syndrome; Sulfonamides; Urticaria

Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Antipyrine; Aspirin; Body Temperature; Capillary Permeability; Chlorpromazine; Cycloheptanes; Erythema; Hexobarbital; Ketones; Male; Mice; Motor Activity; Pentylenetetrazole; Rats; Salicylates; Sleep; Strychnine

Topics: Animals; Anti-Inflammatory Agents; Cortisone; Disease Models, Animal; Edema; Erythema; Inflammation; Phenylbutazone; Rabbits; Rats; Salicylates

Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Dermatitis, Contact; Erythema; Humans; Infant; Male; Ointments; Salicylates; Scalp Dermatoses; Skin Absorption; Water-Electrolyte Balance

Topics: Adolescent; Adult; Child; Dermatitis, Contact; Erythema; Female; Humans; Hypersensitivity, Delayed; Male; Methoxsalen; Middle Aged; Photosensitivity Disorders; Salicylates; Skin Tests; Sunscreening Agents

Topics: Adult; Aged; Anilides; Animals; Anti-Infective Agents, Local; Erythema; Female; Fluorescence; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Photosensitivity Disorders; Salicylates; Skin Tests; Soaps; Spectrophotometry; Sunburn; Ultraviolet Rays

Topics: Drug Hypersensitivity; Eczema; Erythema; Female; Humans; Lanolin; Leg Dermatoses; Male; Ointments; Salicylates; Skin Tests

Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Codeine; Dextropropoxyphene; Erythema; Female; Guinea Pigs; Inflammation; Male; Oxyphenbutazone; Phenylbutazone; Placebos; Propionates; Rats; Salicylates; Sodium

Topics: Aminopyrine; Angioedema; Anti-Bacterial Agents; Barbiturates; Dermatitis, Contact; Drug Hypersensitivity; Erythema; Erythema Multiforme; Erythema Nodosum; Exanthema; Humans; Hungary; Pertussis Vaccine; Purpura; Quinine; Salicylates; Smallpox Vaccine; Stevens-Johnson Syndrome; Sulfonamides; Tetanus Antitoxin; Tranquilizing Agents; Vaccinia

Topics: Acne Vulgaris; Antifungal Agents; Dermatomycoses; Dexamethasone; Erythema; Humans; Pharmaceutic Aids; Salicylates; Thiazoles; Tinea; Tinea Versicolor

Topics: Adrenocorticotropic Hormone; Cortisone; Erythema; Humans; Rheumatic Fever; Salicylates; Skin Diseases, Genetic

Topics: Adrenocorticotropic Hormone; Erythema; Salicylates; Sodium Salicylate