salicylates and Dermatomyositis

Topics: Adolescent; Chemical and Drug Induced Liver Injury; Dermatomyositis; Female; Hepatitis; Humans; Salicylates

Topics: Adolescent; Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Brain; Child; Child, Preschool; Dermatomyositis; Electroencephalography; Female; Gold; Humans; Lupus Erythematosus, Systemic; Male; Phenylbutazone; Psoriasis; Salicylates; Scleroderma, Localized; Sex Factors

Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Biopsy; Connective Tissue; Dermatomyositis; Diphosphates; Gout; Humans; Hyperparathyroidism; Inflammation; Joint Diseases; Lupus Erythematosus, Systemic; Neutrophils; Polyarteritis Nodosa; Psoriasis; Rheumatoid Factor; Salicylates; Sarcoidosis; Spondylitis, Ankylosing; Synovial Fluid; Synovial Membrane; Uric Acid

In 8 out of 32 juvenile patients suffering from chronic polyarthritis and in one patient with dermatomyositis, raised transaminase levels were found; the salicylate level was above 35 mg/100 ml in all except one. Reduction in the salicylate level led to a prompt fall in the serum transaminases. Despite a rise in alkaline phosphatase in three cases there was no other evidence of liver dysfunction in the children. Only one of the adults showed a rise in transaminase levels, and she had mild cirrhosis.

Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Alkaline Phosphatase; Arthritis, Juvenile; Aspartate Aminotransferases; Aspirin; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dermatomyositis; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Salicylates

Topics: Aspartate Aminotransferases; Blood Chemical Analysis; Blood Sedimentation; Chloroquine; Creatine; Creatinine; Dermatomyositis; Diagnosis, Differential; Electromyography; Hemoglobins; Humans; Myositis; Neutrophils; Phenylbutazone; Prednisolone; Salicylates; Urine