salicylates and Dermatomycoses

In tropical primary health care, essential drugs should be safe, effective, and as inexpensive as possible. To treat the very common dermatophyte infections of the skin, one may use inexpensive Whitfield's preparations, more expensive topical imidazole derivatives, or extremely expensive oral antifungals. Because a cream base is felt to be more appropriate than an ointment in tropical conditions, we wanted to compare the effectiveness of Whitfield's cream and a topical imidazole derivative in field conditions in the tropics.. A double-blind trial was performed involving 153 patients with a dermatophyte infection of the skin in Karonga District, Northern Malawi, including 25 patients who were HIV-1-seropositive, comparing Whitfield's cream with clotrimazole cream.. 75 patients were treated with Whitfield's cream and 78 with clotrimazole cream for a period of 6 weeks. Cure rates ranged from 80% to over 90% depending on the definition of cure. If positive cultures after treatment were used as criterion for treatment failure, six were found in each treatment group. One in each treatment failure group was an HIV-1-seropositive patient.. The great majority of patients in the tropics with a dermatophyte infection of the skin can be cured with a topical antimycotic preparation and do not need expensive oral therapy. This also proved to be valid for HIV-1-seropositive patients. Whitfield's cream and clotrimazole cream are both very effective. The lower cost makes Whitfield's cream the treatment of choice in dermatophyte infections of the skin in tropical primary health care.

Topics: Adolescent; Adult; Benzoates; Child; Clotrimazole; Dermatologic Agents; Dermatomycoses; Double-Blind Method; Drug Combinations; Epidermophyton; Follow-Up Studies; HIV Seropositivity; Humans; Malawi; Microsporum; Ointments; Salicylates; Tropical Climate; Tropical Medicine

Topics: Administration, Topical; Antifungal Agents; Benzoates; Clinical Trials as Topic; Dermatomycoses; Double-Blind Method; Humans; Imidazoles; Ointments; Salicylates; Thailand; Tolnaftate

Topics: Adult; Aged; Antifungal Agents; Clinical Trials as Topic; Dermatomycoses; Double-Blind Method; Drug Combinations; Female; Humans; Hydroxybenzoates; Male; Middle Aged; Salicylates; Tolnaftate; Xanthenes

Topics: Bacterial Infections; Clinical Trials as Topic; Dermatomycoses; Drug Combinations; Humans; Ointments; Pregnadienetriols; Salicylates; Skin Diseases, Infectious

Topics: Adolescent; Adult; Animals; Candidiasis; Clinical Trials as Topic; Clotrimazole; Dermatomycoses; Erythrasma; Female; Humans; Imidazoles; Male; Middle Aged; Nystatin; Rats; Salicylates; Tinea; Tinea Versicolor

Topics: Acetates; Arthrodermataceae; Bacitracin; Candida; Chronic Disease; Clinical Trials as Topic; Dermatomycoses; Drug Resistance, Microbial; Humans; Manganese; Nails; Neomycin; Phenanthrolines; Polymyxins; Quinolines; Salicylamides; Salicylates; Skin; Skin Diseases, Infectious; Sulfates

Seventy-four patients with smooth skin microsporosis with involvement of the lanugo were treated with a 10% quinosol solution in dimexid. The foci were smeared twice a day. Resolution of the clinical manifestations and elimination of the fungi were achieved in 5-14 days, in 9.4 days on an average. This therapeutic method does not involve manual epilation and oral griseofulvin, no side effects were recorded.

Topics: Adolescent; Antifungal Agents; Child; Child, Preschool; Dermatomycoses; Dimethyl Sulfoxide; Drug Therapy, Combination; Female; Hair Diseases; Humans; Male; Microsporum; Oxyquinoline; Salicylates; Salicylic Acid; Solutions

The drugs used in the treatment of superficial mycoses include substances with an indirect affect on the organisms such as the keratolytics as well as antifungal compounds. The antifungals include specific inhibitory compounds such as the polyene or imidazole antibiotics and substances with a wider spectrum of antiseptic activity. High cure rates (80-90%) can be achieved by most specific antifungals although this can be affected by the host response and the location of the infection. The orally active antifungals used in superficial disease, ketoconazole and griseofulvin, can be used in conditions unresponsive or inaccessible to topical therapy, such as chronic superficial candidosis and tinea capitis. However, the treatment of onychomycosis, particularly affecting toe nails, is highly unsatisfactory. There is therefore an important place for new drugs and new methods of applying them in the treatment of superficial (local) mycoses.

Topics: Administration, Oral; Administration, Topical; Amphotericin B; Antifungal Agents; Benzoates; Dermatomycoses; Drug Combinations; Etretinate; Female; Griseofulvin; Humans; Imidazoles; Ketoconazole; Nystatin; Potassium Permanganate; Resorcinols; Salicylates; Salicylic Acid; Suppositories; Tretinoin; Vagina

Topics: Animals; Antifungal Agents; Dermatomycoses; Glycosides; Guinea Pigs; Humans; Mice; Salicylates

This paper reports on the clinical trials of an antimycoticum using 5-chlorine-8-hydroxychinolin as an antimycotic agent. 142 patients with surface dermatomycoses were treated locally with the preparation for 5 to 6 weeks. Clinical and mycological healing was achieved in 68% of the cases. The results of the treatment, the epicutaneous tests and the additional UV exposition are discussed. The best results of treatment were obtained in the case of superficial dermatomycoses, in particular Trichophytia inguinalis.

Topics: 1-Propanol; Adult; Antifungal Agents; Benzoates; Dermatomycoses; Drug Combinations; Female; Humans; Hydroxyquinolines; Male; Oxyquinoline; Salicylates; Skin Tests; Ultraviolet Therapy

Topics: Adult; Animals; Benzoates; Child; Dermatomycoses; Dogs; Female; Griseofulvin; Guinea Pigs; Humans; Male; Microsporum; Salicylates; Tinea; Zoonoses

Topics: Adult; Antifungal Agents; Boron; Child; Child, Preschool; Dermatomycoses; Drug Combinations; Female; Humans; Hydrolyzable Tannins; Male; Middle Aged; Salicylates; Tannins

Topics: Acridines; Antifungal Agents; Benzoates; Dermatomycoses; Fatty Acids; Humans; Iodine; Mercury; Organophosphonates; Phenols; Quaternary Ammonium Compounds; Quinolines; Salicylates; Thymol; Undecylenic Acids

Topics: Arthrodermataceae; Candida; Dermatomycoses; Humans; Salicylates; Trichophyton; Yeasts

Topics: Acne Vulgaris; Antifungal Agents; Dermatomycoses; Dexamethasone; Erythema; Humans; Pharmaceutic Aids; Salicylates; Thiazoles; Tinea; Tinea Versicolor

Topics: Amphotericin B; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Dermatomycoses; Humans; Nystatin; Phenols; Quaternary Ammonium Compounds; Quinolines; Salicylates; Sulfides; Sulfonamides; Sulfones; Thiocarbamates

Topics: Adolescent; Adult; Aged; Antifungal Agents; Child; Child, Preschool; Dermatomycoses; Female; Humans; Hydroquinones; Male; Middle Aged; Quaternary Ammonium Compounds; Salicylates

Topics: Adult; Benzoates; Dermatomycoses; Diagnosis, Differential; Female; Humans; Lanolin; Male; Middle Aged; Petrolatum; Resorcinols; Salicylates; Tinea

Topics: Benzoates; Cocos; Dermatomycoses; Drug Combinations; Fungi; Humans; Oils; Ointments; Salicylates; Salicylic Acid

Topics: Antifungal Agents; Bromides; Dermatomycoses; Eczema; Humans; Hydrocortisone; Ointments; Salicylates