salicylates and Dermatitis

Postinflammatory hyperpigmentation (PIH) has posed a substantial challenge for patients with higher Fitzpatrick skin types, specifically types III to VI. Treatment modalities pose a number of limitations due to the number of treatments required, potential side effects, and overall efficacy. Fortunately, multiple therapies have been delineated that can be moderately to highly efficacious in treating PIH in patients with skin of color. This article will review some of these modalities and procedures for this common patient concern.

Topics: Chemexfoliation; Dermatitis; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Ethanol; Glycolates; Humans; Hydroquinones; Hyperpigmentation; Inflammation; Keratolytic Agents; Lactic Acid; Pyrones; Resorcinols; Salicylates; Salicylic Acid; Skin Pigmentation; Tretinoin

Topics: Administration, Topical; Adolescent; Anti-Inflammatory Agents; Candidiasis; Child, Preschool; Dermatitis; Dermatitis, Atopic; Dermatitis, Contact; Dermatitis, Occupational; Dermatitis, Seborrheic; Eczema; Environmental Exposure; Female; Glucocorticoids; Humans; Hyperhidrosis; Infant; Male; Photosensitivity Disorders; Saccharomyces cerevisiae; Salicylates; Steroids; Sulfur

Efficacy and tolerance of an alcoholic solution containing 0.64 mg betamethasone-dipropionate plus 20 mg salicylic acid (Diprosalic Solution) were compared with an alcoholic solution containing 0,64 mg betamethasone-dipropionate in a 3 week double blind study in 100 patients with psoriasis and other steroid-responsive dermatoses of dry nature, comprising scalp and other hairy and non-hairy areas of the body. This double blind study was followed by a 3 week open study in another 100 patients with similar diagnosis, using Diprosalic Solution only. Although the therapeutic results of the double blind study showed no significant differences between both treatment groups, distinct advantages of the drug containing salicylic acid could be clearly demonstrated, such as: 1. More rapid onset of action, 2. rapid clearing of scaling, pruritus and inflammation, 3. these advantages are in compliance with the fact that topically applied salicylic acid softens keratin, loosens cornified epithelium and desquamates the epidermis, making the underlying layers more accessible to the antiinflammatory steroid.

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Clinical Trials as Topic; Dermatitis; Dermatitis, Seborrheic; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Eczema; Female; Glucocorticoids; Humans; Male; Middle Aged; Psoriasis; Salicylates; Salicylic Acid

Topics: Adrenal Cortex Hormones; Adult; Clinical Trials as Topic; Dermatitis; Drug Combinations; Eczema; Female; Flumethasone; Humans; Male; Middle Aged; Psoriasis; Salicylates; Skin Diseases

Topics: Adult; Betamethasone; Clinical Trials as Topic; Cost-Benefit Analysis; Dermatitis; Dexamethasone; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Middle Aged; Ointments; Salicylates

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials as Topic; Dermatitis; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Ointments; Pregnadienetriols; Psoriasis; Salicylates

The aim of this study was to histopathologically examine the reaction of the connective tissue of rats to 2 calcium hydroxide-based sealers, Acroseal and Sealapex. Dentin tubes containing the materials and empty control tubes were implanted into the dorsal connective tissue of 36 Wistar albino rats. The animals were killed after 7 or 30 days, and the specimens were prepared for histologic analysis with hematoxylin and eosin, Von Kossa technique, and polarized light. Results were statistically analyzed using Kruskal-Wallis test. Both materials caused mild or moderate inflammatory reactions on the 7th day, but these reactions decreased by the 30th day with no significant difference at any time (P > .05). Mineralization of the subcutaneous tissue of the rats was observed only with Sealapex.

Topics: Animals; Biocompatible Materials; Calcium Hydroxide; Connective Tissue; Dentin; Dermatitis; Humans; Lymphocytes; Macrophages; Male; Materials Testing; Necrosis; Neutrophils; Ossification, Heterotopic; Plasma Cells; Random Allocation; Rats; Rats, Wistar; Root Canal Filling Materials; Salicylates; Skin; Time Factors

The time course, dose response, components of inflammation, and involvement of putative mediators of inflammation in irritation induced by different chemicals was compared using a mouse ear swelling technique. Differences in time courses of inflammation produced by the irritants were not solely due to differences in rates of penetration. Changes in blood flow and permeability of vessels were phasic with different numbers of phases induced by different irritants. Effects of antagonist, synthesis, inhibitors, and depleting agents of putative inflammatory mediators on intensity of inflammation varied for different irritants. These studies demonstrate that all chemicals do not produce skin irritation by a common inflammatory pathway.

Topics: Alkynes; Animals; Animals, Laboratory; Capillary Permeability; Croton Oil; Dermatitis; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred ICR; Regional Blood Flow; Salicylates; Skin; Skin Absorption

Topics: Administration, Topical; Dermatitis; Dermatitis, Exfoliative; Drug-Related Side Effects and Adverse Reactions; Hexachlorocyclohexane; Humans; Mutagenicity Tests; Pharmaceutical Preparations; Psoriasis; Risk; Salicylates; Skin; Time Factors

Topics: Administration, Topical; Dermatitis; Drug Combinations; Drug Evaluation; Flumethasone; Humans; Salicylates; Solutions

Topics: Dermatitis; Dermatitis, Seborrheic; Drug Combinations; Drug Evaluation; Humans; Pregnadienetriols; Psoriasis; Salicylates; Solutions

The acute contra-inflammatory effects of salicylic acid, three standard dermatocorticoids and four contact antiphlogistics have been investigated by means of a UV dermatitis inhibition test in the guinea pig. The substances tested had a distinct inhibitory effect on the development of erythema and can be ranked in the following ascending order of activity (percent of maximum possible score): bufexamac = 36%, salicylic acid = 37%, hydrocortisone = 44%, acetylsalicylic acid = 48%, flumethasone pivalate = 51%, fluocinolone acetonide = 51%, phenylbutazone = 56%, and indomethacin = 58%.

Topics: Administration, Topical; Animals; Aspirin; Bufexamac; Dermatitis; Flumethasone; Fluocinolone Acetonide; Guinea Pigs; Hydrocortisone; Indomethacin; Male; Phenylbutazone; Salicylates

Topics: Chloramphenicol; Dermatitis; Humans; Mouth; Salicylates; Sulfur; Triamcinolone Acetonide

Topics: Administration, Topical; Anti-Inflammatory Agents; Dermatitis; Dermatitis, Seborrheic; Dermatologic Agents; Drug Prescriptions; Eczema; Female; Humans; Hydrocortisone; Male; Neomycin; Ointment Bases; Psoriasis; Salicylates; Skin Diseases; Sulfur; Tetracycline

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Benzalkonium Compounds; Dermatitis; Female; Humans; Hydrocortisone; Male; Psoriasis; Salicylates; Skin Diseases; Solutions; Triamcinolone Acetonide

Topics: Dermatitis; Dermatitis, Seborrheic; Drug Combinations; Eczema; Flumethasone; Humans; Ointments; Prurigo; Salicylates; Skin Diseases; Staphylococcus

Topics: Adult; Aged; Anti-Inflammatory Agents; Dermatitis; Eyelids; Female; Humans; Infant; Male; Middle Aged; Ointments; Salicylates; Samarium; Sulfonic Acids

Topics: Adolescent; Adult; Aged; Coal Tar; Dermatitis; Dermatologic Agents; Drug Eruptions; Eczema; Female; Flumethasone; Fluorine; Glucocorticoids; Humans; Lichen Planus; Male; Middle Aged; Pregnanes; Psoriasis; Salicylates

Topics: Anti-Bacterial Agents; Bacteria; Corynebacterium; Dermatitis; Enterobacteriaceae; Escherichia coli; Humans; In Vitro Techniques; Ointments; Pantothenic Acid; Proteus; Pseudomonas aeruginosa; Salicylates; Staphylococcus

Topics: Acetates; Aminopyrine; Animals; Calcium Chloride; Coloring Agents; Dermatitis; Dextrans; Drug Synergism; Formaldehyde; Glucuronates; Histamine; Hydrocortisone; Inflammation; Male; Methods; Mice; Passive Cutaneous Anaphylaxis; Salicylates; Serum Albumin, Bovine; Spectrophotometry; Tripelennamine

Topics: Antifungal Agents; Dandruff; Dermatitis; Dermatitis, Seborrheic; Humans; Salicylates; Scalp Dermatoses; Sebaceous Gland Diseases

Topics: Dermatitis; Dermatitis, Seborrheic; Disease; Humans; Keratolytic Agents; Salicylates; Scalp; Sebaceous Gland Diseases; Skin Diseases

Topics: Dandruff; Dermatitis; Dermatitis, Seborrheic; Salicylates; Salts; Sebaceous Gland Diseases

Topics: Anti-Infective Agents, Local; Benzoates; Dermatitis; Dermatitis, Contact; Humans; Mercury Compounds; Salicylates; Sulfhydryl Compounds