salicylates and Dermatitis--Exfoliative

Although topical salicylates are widely used, toxicity from this route is rare.. We present an unusual case of salicylism from a topical salicylate preparation in an 80-year-old woman. The patient was admitted to the dermatology service with a diagnosis of erythroderma and was treated with salicylate containing ointments. After six days of treatment the patient became confused and paranoid. A serum salicylate was 3.36 mmol/L (46 mg/dL). The patient was admitted to the intensive care unit were she was rehydrated and treated with bicarbonate and activated charcoal.. Her serum salicylate fell to 1.90 mmol/L (26 mg/dL) over a two day period and she regained a normal mental status.

Topics: Acidosis; Administration, Topical; Aged; Aged, 80 and over; Cognition Disorders; Confusion; Dermatitis, Exfoliative; Drug Monitoring; Female; Humans; Keratolytic Agents; Paranoid Disorders; Risk Factors; Salicylates; Salicylic Acid; Sleep Stages

To evaluate the efficacy of ultraviolet B (UVB) phototherapy for the treatment of psoriasis in patients infected with human immunodeficiency virus (HIV), the response of 14 patients was compared to that of matched seronegative control individuals. All patients were evaluated prior to treatment (baseline) and after 21 treatments for the extent of total body surface area (TBSA) involvement and the quantification of scale, erythema, and thickness of plaques using a scale of 0 (absent) to 4 (severe). The only concomitant medication allowed was salicylic acid in petrolatum. The cumulative score for scale, erythema, and thickness improved 1.9 +/- 0.5 [mean +/- standard error of mean (SEM)] in the HIV group and 2.4 +/- 0.3 in controls. There was 40.9 +/- 7.3% reduction of TBSA involvement in the former and 38.4 +/- 7.6% reduction in the latter group. None of the differences was statistically significant. There was no statistically significant difference in the response to therapy among various stages of immunosuppression in the HIV group. There was also no deterioration of immune status in this group. UVB phototherapy is an effective treatment for psoriasis in patients infected with HIV. The response is identical to that of matched control individuals.

Topics: Administration, Cutaneous; Adult; Antiviral Agents; Body Surface Area; Case-Control Studies; CD4 Lymphocyte Count; Dermatitis, Exfoliative; Erythema; HIV Infections; HIV Seronegativity; Humans; Immunocompromised Host; Keratolytic Agents; Male; Psoriasis; Salicylates; Salicylic Acid; Ultraviolet Rays; Ultraviolet Therapy; Zidovudine

Topics: Aged; Anemia, Hemolytic; Dermatitis, Exfoliative; Diflunisal; Drug Hypersensitivity; Female; Humans; Liver Function Tests; Middle Aged; Prednisone; Salicylates

Topics: Administration, Topical; Dermatitis; Dermatitis, Exfoliative; Drug-Related Side Effects and Adverse Reactions; Hexachlorocyclohexane; Humans; Mutagenicity Tests; Pharmaceutical Preparations; Psoriasis; Risk; Salicylates; Skin; Time Factors

Topics: Acute Disease; Aged; Dermatitis, Exfoliative; Diflunisal; Female; Humans; Nephritis, Interstitial; Salicylates

Topics: Adrenal Cortex Hormones; Age Factors; Borates; Child; Child, Preschool; Dermatitis, Exfoliative; Dermatitis, Seborrheic; Diagnosis, Differential; Diaper Rash; Glomerulonephritis; Humans; Impetigo; Infant; Infant, Newborn; Lung Abscess; Neurodermatitis; Osteomyelitis; Pneumonia; Salicylates; Skin Absorption; Skin Diseases

Topics: Adolescent; Adult; Aged; Ampicillin; Analgesics; Anaphylaxis; Angioedema; Anti-Bacterial Agents; Barbiturates; Child; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; Erythema; Exanthema; Female; Humans; Infant; Male; Middle Aged; Penicillins; Photosensitivity Disorders; Salicylates; Stevens-Johnson Syndrome; Sulfonamides; Urticaria

Topics: Adult; Child; Coal Tar; Dermatitis, Exfoliative; Flumethasone; Fluorine; Glucocorticoids; Humans; Male; Middle Aged; Occlusive Dressings; Pregnanes; Psoriasis; Salicylates