salicylates and Deafness

Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Deafness; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Salicylates; Time Factors; Tinnitus

A crossover double-blind controlled trial was performed on 36 patients with rheumatoid arthritis to assess the necessity for serum salicylate monitoring in determining optimal dosage. There was no clinically or statistically significant increase in the clinical improvement of patients associated with serum monitoring but potentially toxic serum levels occurred without tinnitus when serum monitoring was not used.

Topics: Arthritis, Rheumatoid; Aspirin; Deafness; Double-Blind Method; Drug Administration Schedule; Evaluation Studies as Topic; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Salicylates; Tinnitus

This article briefly reviews the nature of the toxic effects of drugs on the inner ear and the incidence of ototoxic side effects in man. There follows a more detailed discussion of the most important groups of ototoxic drugs which are identified as the aminoglycoside antibiotics, the "loop" diuretics, quinine and chloroquine, the salicylates and some antitumour drugs. Attention is drawn to the synergistic interaction between aminoglycoside antibiotics and "loop" diuretics and the predisposition to ototoxicity if the drugs are given to subjects with renal impairment. The comparative ototoxicological potential of individual aminoglycosides is discussed and their toxic effects on the kidney and the neuromuscular junction summarized. The importance of an understanding of the pharmacokinetics of aminoglycosides both in relation to toxicity and the rational control of therapy is emphasized.

Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Chloroquine; Deafness; Diuretics; Ear, Inner; Hair Cells, Auditory; Humans; Kidney; Kinetics; Neuromuscular Junction; Quinine; Salicylates

Topics: Adult; Aged; Deafness; Female; Humans; Male; Middle Aged; Movement Disorders; Salicylates; Tinnitus

Topics: Aged; Aspirin; Deafness; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Salicylates; Sex Factors; Tablets

A comprehensive review is presented of the ototoxic effects of drugs which may damage hearing. These have been classified in tabular form together with the recommended dose, method of administration, and ill-effects upon the inner ear. Special emphasis is laid upon the hazard of prescribing such drugs in certain conditions, including in particular the presence of renal or hepatic insufficiency, and the importance of laboratory assessment of new antibiotics for ototoxicity before undertaking clinical trials.

Topics: Aminoglycosides; Anti-Bacterial Agents; Antimalarials; Contraceptives, Oral; Deafness; Ethacrynic Acid; Ethanol; Humans; Nicotine; Salicylates

Topics: Deafness; Female; Humans; Male; Middle Aged; Rheumatic Diseases; Salicylates

Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Deafness; Dihydrostreptomycin Sulfate; Ethacrynic Acid; Female; Humans; Infant, Newborn; Kanamycin; Neomycin; Pregnancy; Quinine; Salicylates; Streptomycin

Topics: Adolescent; Aminoglycosides; Anti-Bacterial Agents; Antineoplastic Agents; Deafness; Diuretics; Ear Diseases; Ear, Middle; Female; Hearing Aids; Humans; Iatrogenic Disease; Male; Middle Aged; Postoperative Complications; Radiotherapy; Salicylates

Topics: Animals; Arsenic; Deafness; Female; Guinea Pigs; Male; Organ of Corti; Quinine; Salicylates

Topics: Animals; Arsenic; Cholinesterases; Deafness; Female; Guinea Pigs; Male; Quinine; Salicylates; Temporal Lobe

Topics: Acetanilides; Acetates; Arthritis, Rheumatoid; Deafness; Humans; Salicylates; Tinnitus

Topics: Adult; Audiometry; Cranial Nerves; Deafness; Electrooculography; Female; Humans; Labyrinth Diseases; Neurologic Manifestations; Nystagmus, Pathologic; Salicylates; Sarcoidosis; Vertigo; Vestibular Function Tests; Vestibulocochlear Nerve

Topics: Aging; Audiometry; Deafness; Humans; Labyrinth Diseases; Labyrinthine Fluids; Meniere Disease; Nerve Degeneration; Organ of Corti; Perceptual Disorders; Prognosis; Salicylates

Topics: Alcohol Oxidoreductases; Animals; Cats; Chemical Phenomena; Chemistry; Deafness; Ear, Inner; Electrophysiology; Glucose; Injections, Intraperitoneal; Labyrinthine Fluids; Potassium; Proteins; Salicylates; Sodium

Topics: Animals; Cats; Deafness; Electrophysiology; Guinea Pigs; Hearing; Salicylates