salicylates and Common-Cold

We report the case of a 4-years-old boy who was admitted with hypovolemic shock due to a severe gastrointestinal bleeding. The esophagogastroduodenoscopy (EGDS) showed hiatus hernia, erosions and ulcerations of the lower esophagus, possibly due to a gastroesophageal reflux, and a small duodenal erosion. The child was previously healthy and he had never shown any symptoms related to this condition. The only product taken by the child in the previous days was a syrup containing several herbs, among which Filipendula ulmaria (L.) Maxim. and Salix spp. (known to contain salicylates), marketed as food and prescribed by his paediatrician to treat a mild cold accompanied by fever. Quali-quantitative analysis confirmed the presence of salicylates in the syrup. Naranjo algorithm showed a probable correlation between the onset of symptoms and the consumption of the herbal remedy. The child recovered after receiving intensive care. The product was withdrawn from Italian market.

Topics: Child, Preschool; Chromatography, High Pressure Liquid; Common Cold; Critical Care; Drug Recalls; Endoscopy, Digestive System; Gastrointestinal Hemorrhage; Hernia, Hiatal; Humans; Italy; Male; Plant Preparations; Reference Standards; Salicylates; Shock

We report a case of eosinophilic pneumonia induced by Pelex granule. A 31-year-old male patient had been treated with Pelex granule and other drugs for common-cold symptoms such as cough and fever. Since these symptoms were persistent, he was admitted to our hospital for further examination. His laboratory findings showed eosinophilia and a mild elevation of serum IgE. Chest radiography revealed a reticular shadow and patchy shadows in both lung fields. Analysis of the bronchoalveolar lavage fluid (BALF) showed an increased percentage of eosinophils. The histological findings of the specimen obtained by transbronchial lung biopsy showed infiltration of eosniophils into the alveolar walls and spaces. After withdrawal of all drugs, the patient's clinical findings-symptoms, laboratory data, and chest radiographic findings-soon improved. A lymphocyte stimulation test (LST) for Pelex granule was positive. Taken together, the case was diagnosed as eosinophilic pneumonia induced by Pelex granule.

Topics: Acetaminophen; Adult; Common Cold; Humans; Male; Pulmonary Eosinophilia; Salicylates

Topics: Anti-Allergic Agents; Choline; Common Cold; Histamine H1 Antagonists; Measles; Narcotics; Salicylates; Sympathomimetics

Topics: Aminopyrine; Anthelmintics; Cardiovascular Agents; Common Cold; Hypothermia, Induced; Muscle Relaxants, Central; Salicylates