salicylates has been researched along with Coma* in 23 studies
5 review(s) available for salicylates and Coma
Article | Year |
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[Therapy of acute salicylate poisoning].
Poisoning with salicylic acid and its derivatives is a quite common event, leading to possibly life-threatening complications. A case of fatal intoxication of a sixty-year old patient with acetylsalicylic acid is described and the therapeutic options are discussed. In acute poisoning it is mandatory to initiate simple and effective measures first. This gives time for discussing and planning the more laborious procedures. The initial treatment of salicylate poisoning is based on the prevention of further absorption by a sufficiently large quantity of orally administered activated charcoal (approximately 1 g/kg b.w.). Given repeatedly, activated charcoal may enhance non-renal clearance of salicylates. Intravenously administered sodium bicarbonate counteracts the metabolic acidosis. Moreover, bicarbonate therapy limits tissue distribution of the drug and enhances its renal excretion. The availability of glycine for salicylic acid metabolism may be limited in poisoning because glycine has been used for forming the conjugation product salicyluric acid. Glycine may be administered orally to overcome this bottleneck. Gastric lavage has been proven to be of limited efficacy. This efficacy is further diminished if gastric lavage is performed late after drug ingestion. When it is performed, however, activated charcoal should be administered before and after gastric lavage. Whenever the more simple treatment options fail, hemodialysis or hemoperfusion should be additionally considered since these procedures are effective in removing salicylates from the body. Topics: Aspirin; Charcoal; Coma; Fatal Outcome; Female; Fever; Gastric Lavage; Glycine; Hemoperfusion; Humans; Middle Aged; Poisoning; Renal Dialysis; Salicylates; Sodium Bicarbonate | 1993 |
Drug-induced hypoglycemia. A review of 1418 cases.
The present review catalogues 1418 reported cases of drug-induced hypoglycemia. The main findings are that sulfonylureas (especially chlorpropamide and glyburide), either alone or with a second hypoglycemic or potentiating agent, still account for 63% of all cases; that alcohol, propranolol, and salicylate, either singly or with another hypoglycemic drug, are the next most frequent offenders (19% of the total); and that one older drug (quinine) and three new ones (pentamidine, ritodrine, and disopyramide) have caused an additional 7% of all episodes of severe hypoglycemia. The clinical factors that set the stage for drug-induced hypoglycemia are still restricted food intake, age, hepatic disease, and renal disease, both individually and even more so in combination. Drug-induced hypoglycemia continues to be so common that virtually every unconscious patient should be considered hypoglycemic until immediate estimation of the blood sugar level rules it in or out. If ruled in, the clinician should promptly start 10% intravenous glucose and plan to maintain it uninterruptedly for 1 or more days, with added glucagon, hydrocortisone, and diazoxide administration if necessary, until sustained hyperglycemia guarantees that all drug effects have worn off. Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Coma; Humans; Hypoglycemia; Hypoglycemic Agents; Infant; Infant, Newborn; Middle Aged; Salicylates; Sulfonylurea Compounds | 1989 |
Determination of drugs in biologic specimens--a review.
Topics: Amphetamine; Amphetamines; Autoanalysis; Barbiturates; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Coma; Electron Spin Resonance Spectroscopy; Humans; Hydrogen-Ion Concentration; Imipramine; Lysergic Acid Diethylamide; Magnetic Resonance Spectroscopy; Mass Spectrometry; Meprobamate; Opium; Pharmaceutical Preparations; Salicylates; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Substance-Related Disorders; Tranquilizing Agents | 1974 |
Drug-induced hypoglycemia. A review based on 473 cases.
Topics: Acetohexamide; Adolescent; Adult; Aminobenzoates; Child; Child, Preschool; Chlorpropamide; Coma; Edetic Acid; Ethanol; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Infant; Infant, Newborn; Insulin; Male; Manganese; Middle Aged; Nutritional Physiological Phenomena; Oxytetracycline; Propranolol; Salicylates; Sulfonylurea Compounds; Tolbutamide | 1972 |
Treatment of salicylate poisoning.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Alkalosis, Respiratory; Aspirin; Calcium; Coma; Dehydration; Fever; Gastric Lavage; Hemorrhage; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Poisoning; Salicylamides; Salicylates; Seizures; Tetany; Vomiting | 1971 |
18 other study(ies) available for salicylates and Coma
Article | Year |
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Hepatic and encephalopathic components of Reye's syndrome: factor analysis of admission data from 209 patients.
Factor analysis of admission data from 209 Reye's syndrome patients yielded three factors. Factor 1 was associated with encephalopathy, blood ammonia, creatinine kinase (CK), uric acid and, to a lesser extent, bilirubin. This factor was linked to the encephalopathy and hypermetabolic changes in muscle, possibly prostaglandin-mediated proteolysis. Factor 2 was associated with serum alanine aminotransferase (AlaAT) and aspartate aminotransferase (AspAT), and was identified as a hepatic lesion component. These factors correspond to two etiologic components of Reye's syndrome. Salicylate was only weakly associated with neuropathic and hypercatabolic indicators and not at all associated with the hepatic damage indicators. Topics: Brain Diseases; Child; Child, Preschool; Coma; Humans; Liver Diseases; Respiratory Tract Infections; Reye Syndrome; Salicylates; Statistics as Topic | 1985 |
Ingestion of codeine and salicylic acid causing convulsions and coma. A case report.
A 3-year-old White child was admitted to the critical care unit in a coma after a generalized convulsion. Codeine and salicylic acid were present in his plasma. The possible aetiology and management are discussed. Topics: Child, Preschool; Codeine; Coma; Humans; Male; Salicylates; Seizures | 1984 |
Effect of ethanol ingestion on outcome of drug overdose.
It was traditionally assumed that ethanol, as part of an intentional drug overdose, will increase morbidity and mortality. The authors prospectively studied the effect of ethanol on the outcome of intentional drug overdose in 468 adults, 196 of whom required hospital admission. Ethanol was detected in significantly fewer patients who required admission. Ethanol ingestion was not related to coma, impaired vital signs or mortality. Indeed, the duration of coma was significantly shorter in patients in whom ethanol was detected, but this group had a lesser incidence of multiple drug and nonbarbiturate hypnotic ingestion and a greater incidence of chronic ethanol use. Thus, it seems that ethanol is not associated with a worse clinical course if the drug overdose patient reaches medical care before an irreversible event. Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Barbiturates; Benzodiazepines; Coma; Diazepam; Drug Interactions; Ethanol; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Nordazepam; Phenothiazines; Poisoning; Salicylates; Suicide, Attempted | 1982 |
Delayed coma associated with salicylate intoxication.
Topics: Aspirin; Brain Edema; Child, Preschool; Coma; Female; Humans; Infant; Mannitol; Salicylates; Time Factors | 1982 |
Use of haemoperfusion with uncoated charcoal in the management of acute intoxications with barbiturate and salicylate.
Topics: Adult; Barbiturates; Blood Pressure; Body Temperature; Charcoal; Coma; Female; Hemoperfusion; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Time Factors | 1981 |
Tricyclic antidepressant poisoning. Reversal of coma, choreoathetosis, and myoclonus by physostigmine.
Topics: Adult; Amitriptyline; Antidepressive Agents; Athetosis; Child, Preschool; Chorea; Coma; Female; Humans; Imipramine; Injections, Intravenous; Male; Myoclonus; Physostigmine; Salicylates | 1974 |
[Salicylate poisoning].
Topics: Acid-Base Equilibrium; Acidosis; Cardiovascular Diseases; Coma; Fever; Gastric Lavage; Gastrointestinal Diseases; Humans; Hydrogen-Ion Concentration; Hyperventilation; Neurologic Manifestations; Oxygen Consumption; Peritoneal Dialysis; Renal Dialysis; Salicylates; Water-Electrolyte Balance | 1973 |
Contribution of electroencephalography to resuscitation in toxicology.
Topics: Amitriptyline; Barbiturates; Carbon Monoxide Poisoning; Coma; Electroencephalography; Fungi; Humans; Imipramine; Insecticides; Isoniazid; Poisoning; Resuscitation; Salicylates; Time Factors; Trichloroethylene | 1973 |
Dermographism, erythema, and flare: clinical signs of drug overdose in the comatose patient.
Topics: Adult; Alcoholic Intoxication; Barbiturates; Bromides; Coma; Diagnosis, Differential; Diazepam; Erythema; Female; Humans; Male; Salicylates; Skin Manifestations; Substance-Related Disorders | 1973 |
Emergency and intensive care of acute poisoning.
Topics: Acute Disease; Adult; Barbiturates; Charcoal; Coma; Emergency Service, Hospital; First Aid; Humans; Intensive Care Units; Poisoning; Psychology; Respiratory Function Tests; Salicylates; Shock; Vomiting | 1973 |
Coma following nonnarcotic drug overdosage: management of 208 adult patients.
Topics: Adolescent; Adult; Age Factors; Aged; Antidepressive Agents; Barbiturates; Child; Coma; Diuresis; Female; Glutethimide; Humans; Hypnotics and Sedatives; Male; Middle Aged; Peritoneal Dialysis; Poisoning; Renal Dialysis; Salicylates; Sex Factors; Statistics as Topic; Time Factors; Tranquilizing Agents | 1973 |
Salicylate poisoning in the elderly: diagnostic pitfalls.
Topics: Acidosis; Aged; Alcoholic Intoxication; Alkalosis; Alkalosis, Respiratory; Arrhythmias, Cardiac; Coma; Diabetic Ketoacidosis; Diagnosis, Differential; Encephalitis, Arbovirus; Humans; Male; Myocardial Infarction; Poisoning; Salicylates; Stomach Neoplasms; Sweating | 1972 |
[Toxic comas in a respiratory resuscitation unit. A 3-year observation].
Topics: Adolescent; Adult; Aged; Antidotes; Barbiturates; Carbon Monoxide Poisoning; Child; Coma; Diuretics; Female; Humans; Male; Middle Aged; Respiration, Artificial; Salicylates; Tranquilizing Agents | 1967 |
ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA.
Topics: Aspirin; Brain Diseases; Carbohydrate Metabolism; Coma; Fatty Liver; Heart Diseases; Humans; Kidney Diseases; Salicylates; Toxicology; Viscera | 1965 |
SCREENING TEST FOR HIGH SERUM SALICYLATE LEVELS.
Topics: Aspirin; Blood Chemical Analysis; Body Fluids; Coma; Indicators and Reagents; Salicylates; Toxicology; Urine | 1964 |
ACUTE SALICYLATE POISONING IN ADULTS.
Topics: Acute Kidney Injury; Aspirin; Blood Chemical Analysis; Bronchopneumonia; Coma; Diagnosis, Differential; Diuresis; Gastric Lavage; Heart Arrest; Heart Failure; Humans; Infusions, Parenteral; Kidney; Kidneys, Artificial; Phenacetin; Poisoning; Pulmonary Edema; Renal Insufficiency; Salicylates; Statistics as Topic; Toxicology | 1964 |
SALICYLATE POISONING: THE DIAGNOSIS WHEN ITS POSSIBILITY IS DENIED BY THE PARENTS.
Topics: Aspirin; Child; Coma; Diabetic Coma; Diagnosis; Diagnosis, Differential; Humans; Hyperglycemia; Infant; Parent-Child Relations; Parents; Poisoning; Salicylates; Toxicology; Urine | 1964 |
Gastric secretory studies during prolonged salicylate administration in a comatose man.
Topics: Coma; Gastric Juice; Salicylates | 1958 |