salicylates and Cicatrix

The Jessner's-trichloroacetic acid (TCA) peel is a procedure developed by Monheit to produce a safe, effective medium-depth chemical peel for the treatment of photoaged skin, actinic keratoses, and superficial acne scars. The technique of pretreatment degreasing and combination chemicals allow a deeper penetration for the 35% TCA, increasing its efficacy while preserving its safety. Technique and methods are reviewed.

Topics: Acne Vulgaris; Chemexfoliation; Cicatrix; Drug Combinations; Ethanol; Face; Facial Dermatoses; Humans; Keratosis; Lactates; Lactic Acid; Resorcinols; Salicylates; Skin Aging; Trichloroacetic Acid

Topics: Animals; Bone Regeneration; Burns; Cicatrix; Collagen; Disease Models, Animal; Drug Interactions; Guinea Pigs; Humans; Leukocytes; Methotrexate; Rabbits; Rats; Salicylates; Skin Transplantation; Surgery, Plastic; Tendon Injuries; Wound Healing

Topics: Acne Vulgaris; Chemexfoliation; Cicatrix; Combined Modality Therapy; Cosmetic Techniques; Drug Combinations; Ethanol; Humans; Lactic Acid; Needles; Quality of Life; Resorcinols; Salicylates

Multiple modalities are available for treating acne scars, one of which is chemical peeling.. To evaluate the efficacy of medium-depth peels in the treatment of acne scars.. A total of 15 patients (14 women and 1 man) were seen between November 1998 and March 2000. A medium-depth chemical peel was performed. The peel was performed using a combination of Jessner's solution followed by the application of 35% trichloroacetic acid (TCA). The mean age of patients who entered the study was 28 years. A total of 42 peeling sessions were performed: 13 patients had the full three-session regiment, 1 patient had two sessions, and 1 had only one session.. Patients in our study had two forms of acne scars, the atrophic saucer or crater-like form and the pitted (ice-pick) form. Improvement occurred in all except one of our patients. Significant improvement (greater than 75% clearance of lesions) occurred in 1 patient (6.6%), moderate improvement (51-75% clearance) in 8 patients (53.3%), mild improvement (26-50% clearance) in 4 patients (26.6%), minimal improvement (1-25% clearance) in 1 patient (6.6%), and no response in 1 patient (6.6%). All patients had different combinations of the above two forms. Four patients (26.6%) had mainly pitted scars and deep atrophic scars. The clinical response in those patients was moderate, mild, minimal, and no response, respectively. The remainder of our patients had mainly atrophic scars of moderate depth. Nine patients (73.4%) suffered from transient postinflammatory hyperpigmentation. In two of them it was preceded by erythema that lasted for more than 1 month. All patients were free of noticeable pigmentation 3 months after the final peel. Patients in whom hyperpigmentation did not develop were of light brown complexion.. We conclude that medium-depth chemical peel is a safe and effective method of treating acne scars even in patients with dark complexion.

Topics: Acne Vulgaris; Adolescent; Adult; Caustics; Chemexfoliation; Cicatrix; Drug Combinations; Drug Therapy, Combination; Ethanol; Female; Humans; Iraq; Lactic Acid; Male; Resorcinols; Salicylates; Skin Pigmentation; Trichloroacetic Acid

Topics: Anesthesia, Local; Chemexfoliation; Cicatrix; Dermatologic Agents; Dermatologic Surgical Procedures; Drug Combinations; Erythema; Ethanol; Face; Hair Follicle; Humans; Hydroxy Acids; Lactic Acid; Phenols; Pigmentation Disorders; Preoperative Care; Rejuvenation; Resorcinols; Salicylates; Skin Aging; Surgical Wound Infection; Trichloroacetic Acid

Chemical peels are an effective treatment for wrinkles, but their use is limited because of the associated risk of scarring, hypopigmentation, and the inability to accurately control the depth of tissue injury. High energy, pulsed, or computer scanned continuous wave carbon dioxide (CO2) lasers cause minimal thermal injury, decrease the risk of scarring, and allow for precise control of tissue vaporization to predictable depths.. To compare the effectiveness and side effect profile of a medium-depth chemical peel to that of the SilkTouch CO2 laser in the treatment of periorbital wrinkles.. Twenty-four subjects (nine male, 15 female) with moderate to severe periorbital wrinkles were assigned a wrinkle score (1 = mild through 5 = severe) before treatment and 6 months after treatment. Each subject was treated with Jessner's solution and 35% trichloroacetic acid on one side and the SilkTouch CO2 laser on the other side.. The average periorbital wrinkle score decreased from 4.00 +/- 0.78 before laser treatment to 1.75 +/- 0.68 6 months after treatment. The chemical peel wrinkle score decreased from 4.13 +/- 0.85 to 3.29 +/- 0.99. The degree in which the wrinkle score improved after laser treatment compared with after chemical peel treatment was statistically significant. Posttreatment erythema lasted an average of 4.5 months for the laser-treated areas and 2.5 months for the chemical peel-treated areas.. Treatment of periorbital wrinkles with the SilkTouch CO2 laser resulted in a greater degree of improvement than treatment with a medium-depth chemical peel but had longer lasting posttreatment erythema.

Topics: Administration, Cutaneous; Adult; Aged; Carbon Dioxide; Chemexfoliation; Cicatrix; Drug Combinations; Erythema; Ethanol; Female; Fibrosis; Follow-Up Studies; Forecasting; Humans; Hypopigmentation; Lactic Acid; Laser Therapy; Male; Middle Aged; Orbit; Resorcinols; Rhytidoplasty; Risk Factors; Salicylates; Skin; Skin Aging; Time Factors; Trichloroacetic Acid; Wound Healing

Topics: Administration, Topical; Child; Cicatrix; Facial Injuries; Female; Humans; Lactates; Salicylates; Warts