salicylates and Chickenpox

Topics: Chickenpox; Chickenpox Vaccine; Contraindications; Drug Administration Schedule; Female; Humans; Practice Guidelines as Topic; Pregnancy; Salicylates

Topics: Adult; Chickenpox; Chickenpox Vaccine; Disease Transmission, Infectious; Female; Humans; Immunocompromised Host; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Salicylates; Vaccines, Attenuated

Topics: Adolescent; Antibodies, Viral; Chickenpox; Chickenpox Vaccine; Child; Child, Preschool; Contraindications; Costs and Cost Analysis; Drug Administration Schedule; Erythema; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompromised Host; Infant; Pregnancy; Pregnancy Complications, Infectious; Salicylates; Vaccination; Vaccines, Attenuated; Viral Vaccines

Topics: Adolescent; Adult; Chickenpox; Child; Child, Preschool; Female; Humans; Infant; Influenza, Human; Male; Reye Syndrome; Salicylates; United States

Topics: Adolescent; Adult; Chickenpox; Child; Child, Preschool; Female; Humans; Infant; Influenza, Human; Male; Reye Syndrome; Salicylates; United States

Between February and May 1984, we conducted a pilot study to examine the methods for a larger study of a previously reported relation between Reye's syndrome and medications. Thirty patients with Reye's syndrome, whose diagnosis was confirmed by an expert panel, and 145 controls were matched for age, race (black or not black), and antecedent illness (respiratory infection, chickenpox, or diarrhea) and selected from the same hospital, emergency room, or school, or identified by random digit dialing. Significantly more cases (93 per cent, 28 of 30) than members of each of the four control groups or all controls combined (46 per cent, 66 of 145) had received salicylates during matched antecedent illnesses (odds ratio of all 30 cases vs. all controls = 16.1; lower 95 per cent confidence limit = 4.6). The prevalence and mean severity score of signs, symptoms, and selected events during the antecedent illness tended to be lower among cases than controls. Thus, differences in the severity of this illness between cases and controls did not explain differences in medication exposures. This pilot study suggests an association between Reye's syndrome and the use of salicylates during an antecedent illness.

Topics: Acetaminophen; Adolescent; Chickenpox; Child; Child, Preschool; Emergencies; Female; Humans; Infant; Male; Pilot Projects; Respiratory Tract Diseases; Reye Syndrome; Salicylates; Therapeutic Equivalency; Time Factors

Topics: Adolescent; Chickenpox; Child; Child, Preschool; Humans; Influenza, Human; Reye Syndrome; Salicylates

Topics: Adolescent; Adult; Chickenpox; Child; Child, Preschool; Humans; Indiana; Infant; Infant, Newborn; Influenza, Human; Insecticides; Intracranial Pressure; Middle Aged; Pentobarbital; Reye Syndrome; Salicylates

Fifty-eight children with Reye's syndrome (RS) confirmed by liver biopsy were treated at the University of Cincinnati between 1963 and 1974. Cases were clustered in the winter and spring with the peak in February and March. These coincided with the occurrence of influenza and, numerically, were associated more closely with influenza B than with influenza A. Six of the 58 cases were associated with chickenpox. Twenty-six children with RS were seen from 1963 to 1971, before the beginning of a systematic epidemiologic and virologic study. Viral infection was documented in either the patient or a contact in only 19% of those studied. Between 1971 and 1973, after the study was initiated, 16 cases of RS were diagnosed and viral infection was confirmed in 56% of these. In 1974, an epidemic of RS occurred during an influenza B epidemic and viral infection was found in either the patient or a contact in 81% of 16 cases. This study demonstrates that an association with viral infection can be proven in the majority of cases of RS when an intensive investigation is undertaken. During this study no significant environmental toxic exposures could be idenified. Most children had taken aspirin and other medications, and seven children had a history of excessive aspirin ingestion.

Topics: Adolescent; Biopsy; Brain Diseases; Chickenpox; Child; Child, Preschool; Disease Outbreaks; Environmental Exposure; Female; Humans; Infant; Influenza, Human; Liver; Male; Ohio; Recurrence; Reye Syndrome; Salicylates; Seasons; Vaccines, Attenuated; Viral Vaccines

Topics: Chickenpox; Child; Herpesvirus 3, Human; Humans; Hypoglycemia; Infant; Pancreatic Diseases; Salicylates