salicylates and Cat-Diseases

The metabolism of many analgesic and antiphlogistic agents in dogs and cats differs markedly from that in man or other animals. When the known data on the subject are borne in mind, potentially toxic agents such as acetosal, phenylbutazone, ibuprofen and indomethacin may be used without much risk in various indications. It is pointed out that double-blind studies on the clincal effectiveness in patients unfortunately have not yet become available.

Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Cat Diseases; Cats; Dimethyl Sulfoxide; Dog Diseases; Dogs; Drug Combinations; Glafenine; Narcotics; ortho-Aminobenzoates; Parasympatholytics; Phenacetin; Phenylacetates; Phenylbutazone; Salicylates; Scopolamine Derivatives

The performance of the urine dipstick, sulfosalicylic acid (SSA), and urine protein-to-creatinine (UPC) tests for the detection of albuminuria was assessed in cats with chronic kidney disease (CKD). Two hundred and thirty-nine urine samples from 37 cats with CKD were used. Test results were dichotomized as either positive or negative, compared with those for the feline-specific rapid urine albumin immunoassay and test performance variables calculated for each test. A positive urine dipstick (≥ trace) and positive SSA (≥ 5 mg/dl), positive SSA alone or ≥ 2+ urine dipstick alone were indicative of albuminuria. In these cases, protein quantification would be warranted if proteinuria/albuminuria is persistent. In the case of a negative urine dipstick result the addition of the SSA added little diagnostic value. Of the tests investigated, the single best test for the detection of albuminuria was the UP/C (≥ 0.2) in which either a negative or positive test result provided useful information.

Topics: Albuminuria; Animals; Benzenesulfonates; Cat Diseases; Cats; Enzyme-Linked Immunosorbent Assay; Female; Male; Reagent Strips; Renal Insufficiency, Chronic; Salicylates; Sensitivity and Specificity; Species Specificity

To evaluate the use of dipstick, sulfosalicylic acid (SSA), and urine protein-to-creatinine ratio (UP:C) methods for use in detection of canine and feline albuminuria.. Evaluation study.. 599 canine and 347 feline urine samples.. Urine was analyzed by use of dipstick, SSA, and UP:C methods; results were compared with those for a species-specific ELISA to determine sensitivity, specificity, positive predictive value (PPV), negative predictive value, and positive and negative likelihood ratios.. Positive results for dipstick and SSA tests (trace reaction or greater) in canine urine had moderate specificity (dipstick, 81.2%; SSA, 73.3%) and poor PPV (dipstick, 34.0%; SSA, 41.8%). Values improved when stronger positive results (>or= 2+) for the dipstick and SSA tests were compared with ELISA results (specificity, 98.9% and 99.0% for the urine dipstick and SSA tests, respectively; PPV, 90.7% and 90.2% for the dipstick and SSA tests, respectively). Data obtained for cats revealed poor specificity (dipstick, 11.0%; SSA, 25.4%) and PPV (dipstick, 55.6%; SSA, 46.9%). Values improved slightly when stronger positive test results (>or= 2+) were used (specificity, 80.0% and 94.2% for the dipstick and SSA tests, respectively; PPV, 63.5% and 65.2% for the dipstick and SSA tests, respectively). The UP:C had high specificity for albuminuria in dogs and cats (99.7% and 99.2%, respectively) but low sensitivity (28.7% and 2.0%, respectively).. Caution should be used when interpreting a positive test result of a dipstick or SSA test for canine or feline albuminuria.

Topics: Albuminuria; Animals; Benzenesulfonates; Cat Diseases; Cats; Creatinine; Dog Diseases; Dogs; Enzyme-Linked Immunosorbent Assay; Proteinuria; Reagent Strips; Salicylates; Sensitivity and Specificity; Species Specificity