salicylates and Burns

Topics: Animals; Bone Regeneration; Burns; Cicatrix; Collagen; Disease Models, Animal; Drug Interactions; Guinea Pigs; Humans; Leukocytes; Methotrexate; Rabbits; Rats; Salicylates; Skin Transplantation; Surgery, Plastic; Tendon Injuries; Wound Healing

Hot-iron branding is painful for cattle, but little is known about how long this pain lasts or effective alleviation methods. Previous work with pigs indicated that cooling burns with a gel (active ingredient: tea tree oil) improved healing compared to untreated wounds. Steers (210±21 kg) were hot-iron branded and allocated to 1 of 3 treatments: control (n=24), 1 gel application immediately after branding (1X; n=12), or 2 gel applications, 1 immediately after branding and one 1 d later (2X; n=12). Pain sensitivity was assessed by applying a known and increasing force with a von Frey anesthesiometer in 5 locations (in the center, at the top of, and 5 and 10 cm above the brand and on the equivalent location on the nonbranded side of the body) until animals showed a behavioral response. Healing was measured with a 6-point scale (1=fresh brand and 6=no scabbing and fully repigmented). Both measures, along with weight gain and surface temperature of the wound, were recorded before and 1, 2, 3, 7, 14, 21, 28, 35, 56, and 70 d after branding. The gel cooled the brand, with the most obvious differences on the day it was applied (3.7 to 4.2°C cooler than control; day×gel interaction, P=0.004). All wounds were at least partially repigmented by 70 d, but only 46% of brands were fully healed at this time. The healing process was slowed when a gel was applied twice (e.g., at 21 d, healing score of 2.5±0.1 and 2.7±0.1 vs. 2.0±0.2 for control and 1X vs. 2X, respectively; P=0.001). Brands tended to remain painful throughout the 70 d (in the center of the brand; before vs. d 1-35, P≤0.001; d 56, P=0.058; and d 70, P=0.092). Overall, gel had little effect on pain sensitivity. Weight gain was reduced on d 1 after branding compared to all other time points (P<0.001) but was not affected by gel application (P=0.277). In conclusion, applying gel did not improve outcomes after branding. In addition, by 70 d after the procedure, hot-iron brands still tended to be more painful than nonbranded tissue and 54% were not fully healed. These results raise additional animal welfare concerns about hot-iron branding.

Topics: Analgesics; Animal Husbandry; Animal Welfare; Animals; Body Temperature; Burns; Cattle; Gels; Hot Temperature; Male; Pain; Salicylates; Thermography; Time Factors; Treatment Outcome; Wound Healing

A trial comparing three topical agents was carried out in patients with burns. The substances investigated were 10% povidone-iodine (PVP-I) ointment mixed with a proteolytic agent, 5% PVP-I cream alone and in combination with the same proteolytic agent. Differences were observed in healing times and bacteriological cultures. Shorter healing times were observed in burns treated with PVP-I cream. The addition of a proteolytic agent to the cream made no difference to the results. Fewer positive cultures for Staphylococcus aureus and Pseudomonas aeruginosa were obtained in the groups treated with the cream. It was concluded that 5% PVP-I cream is a safe and effective topical agent in burns.

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Infective Agents, Local; Bacteria; Benzoates; Burns; Child; Child, Preschool; Clinical Trials as Topic; Dosage Forms; Drug Combinations; Humans; Infant; Malates; Middle Aged; Ointments; Povidone; Povidone-Iodine; Salicylates; Wound Healing

Topics: Absorption; Adolescent; Adult; Aged; Burns; Clinical Trials as Topic; Drug Evaluation; Humans; Middle Aged; Necrosis; Ointments; Salicylates

Topics: Benzoates; Burns; Hexachlorophene; Humans; Parabens; Propylene Glycols; Salicylates

Topics: Administration, Cutaneous; Analgesics; Burns; Female; Hot Temperature; Humans; Middle Aged; Musculoskeletal Pain; Nonprescription Drugs; Salicylates

This research was performed to determine whether or not treatment of burn-injured rats with Cu(II)2(3,5-diisopropylsalicylate)4(Cu(II)2(3,5-DIPS)4) facilitated recovery from burn-injury. Four groups of adult male rats received a standard skin burn 1 h before an initial subcutaneous treatment which was continued daily for three days with either 0, 5, 10 or 20micromol Cu(II)2(3,5-DIPS)4/kg body mass. A fifth group was given no treatment. A sixth group served as a non-burn-injured non-treated normal control group. At 3 h and on days 1, 2, 3, 7 and 14 post-burn-injury blood samples were obtained from rats in all groups for the determination of leukocyte, platelet and erythrocyte counts, clotting times, hemoglobin and hematocrit values. Total protein and middle mass peptides in plasma, as well as plasma lipid and erythrocyte membrane peroxidation products were determined on days 7 and 14. Burn wound healing and body mass were determined daily from day 0 to 6 with a notation of crust rejection by day 14. Treatment with Cu(II)2(3,5-DIPS)4 produced effects consistent with a facilitation of Cu-dependent immune-mediated physiological inflammatory responses to burn injury. It is concluded that treatment of burn injury with Cu(II)2(3,5-DIPS)4 supports Cu-dependent physiological responses involved in overcoming burn injury, which may have been further optimized by continued treatment beyond day 2, the last day of treatment.

Topics: Animals; Blood Proteins; Burns; Erythrocyte Count; Erythrocyte Membrane; Hematocrit; Hemoglobins; Leukocyte Count; Lipid Peroxidation; Male; Platelet Count; Rats; Rats, Inbred Strains; Salicylates; Whole Blood Coagulation Time

A 4-year-old boy sustained a superficial burn to his finger at the site of a viral papilloma. The burn was treated conservatively. During re-epithelialization the human papilloma virus (HPV) incorporated its genome in the regenerating cells, leading to a verruca as large as the original burn. Diagnosis was reinforced by a history from the patient's mother. Complete resolution of this complication was achieved with topical therapy.

Topics: Antiviral Agents; Burns; Child, Preschool; Finger Injuries; Humans; Male; Papillomaviridae; Salicylates; Wound Healing; Wound Infection

This report relates to burns of the feet suffered by a pilgrim to Mecca who walked barefoot in the hot desert sun. He subsequently presented with full-thickness burn injuries to the soles of his feet. When the patient developed acute coronary insufficiency, immediate surgery could not be performed. He was therefore treated conservatively with salicylic acid and Silverol cream. Spontaneous closure of the wounds was achieved in the course of 2 months.

Topics: Acute Disease; Anti-Infective Agents, Local; Burns; Cardiac Output, Low; Foot Injuries; Humans; Islam; Keratolytic Agents; Male; Middle Aged; Salicylates; Salicylic Acid; Saudi Arabia; Silver Sulfadiazine

Prostaglandin E2 (PGE2) has been implicated in postburn immunosuppression, which is responsible for septic complications. In the present work, seven non-steroidal anti-inflammatory drugs (NSAIDs), differing by their capacity to inhibit the cyclooxygenase pathway, were compared for their ability to restore T lymphocyte proliferative responses evaluated 4 days after thermal injury in rats. Salicylic acid, 5-aminosalicylic acid, and niflumic acid, given daily, fully restored spleen cell responses to concanavalin A (Con A) and phytohemagglutinin. These drugs were active only at doses that were below the anti-inflammatory doses and did not modify normal spleen cell responses. In these conditions, indomethacin slightly restored lymphocyte reactivity, whereas acetylsalicylic acid, ketoprofen, and piroxicam were ineffective. PGE2 production by Con A-stimulated spleen cells from untreated burned rats and after treatment with niflumic acid or 5-aminosalicylic acid did not correlate with the intensity of the proliferative response. Indomethacin, niflumic acid, and 5-aminosalicylic acid were added in vitro to spleen cells from normal and burned rats, at concentrations from 10(-7) to 10(-4) M. PGE2 production was strongly depressed by indomethacin and niflumic acid and not modified by 5-aminosalicylic acid. The proliferative response of normal spleen cells was depressed in a concentration-dependent manner by niflumic acid and slightly inhibited at the highest concentrations of indomethacin. In contrast, indomethacin concentration dependently restored the burn-impaired proliferative response, whereas niflumic acid further depressed it and 5-aminosalicylic acid had no effect. These results demonstrate that only some NSAIDs are able to restore T lymphocyte reactivity impaired after thermal injury and that this property is not related to inhibition of PGE2 production.

Topics: Administration, Oral; Amino Acid Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Dinoprostone; Indomethacin; Ketoprofen; Lymphocyte Activation; Male; Niflumic Acid; Nitric Oxide Synthase; Piroxicam; Rats; Rats, Wistar; Salicylates

A cream containing malic, benzoic and salicylic acid esters (Aserbine) was evaluated as a topical dressing for dermal burns. Children with thermal injuries covering less than 20 per cent of the body surface area (BSA) were treated with Aserbine (53 patients), Daromide (31 patients) or silver sulphadiazine (SSD) (16 patients). In these groups, hot liquids were the cause of injury in 92 per cent, 100 per cent and 80 per cent of patients respectively. There were no significant differences in the numbers of patients with clinical evidence of infection. Aserbine did not inhibit the growth of staphylococci or Ps. aeruginosa, partly inhibited beta-haemolytic streptococci and Proteus sp., and completely inhibited the growth of E. coli. The rate of wound healing did not differ significantly between the groups. No toxic effects of Aserbine were observed, apart from transient discomfort on application. Aserbine is a safe, inexpensive topical agent suitable for thermal burns which are not heavily contaminated.

Topics: Anti-Infective Agents, Local; Benzoates; Burns; Child; Child, Preschool; Drug Combinations; Humans; Infant; Malates; Occlusive Dressings; Ointments; Salicylates; Wound Healing

Topics: Aloe; Animals; Aspirin; Burns; Guinea Pigs; Plants, Medicinal; Salicylates

An experimental study was designed using Hartley guinea pigs, who received full-thickness burns covering 3 percent of their body surface area by direct contact with a hot plate. A total of 40 animals were equally divided among four modalities of closed burn wound management as follows: group I: silver sulfadiazine (Silvadine); group II: aloe vera gel extract (Carrington Dermal Wound Gel); group III: salicylic acid cream (aspirin); and group IV: plain gauze occlusive dressing only. The dressings were changed daily, and the size and appearance of each burn wound were recorded until complete healing. On the sixth postburn day, quantitative burn wound cultures were made. The average time to complete healing in the control group was 50 days, and the only significant difference was found in the aloe vera-treated animals, which healed on an average of 30 days (p less than 0.02). Wound bacterial counts were effectively decreased by silver sulfadiazine (p = 0.015) and by aloe vera extract (p = 0.015). From our data it appears that aloe gel extracts permit a faster healing of burn wounds.

Topics: Administration, Topical; Aloe; Animals; Bacterial Infections; Burns; Disease Models, Animal; Gels; Guinea Pigs; Male; Occlusive Dressings; Ointments; Plants, Medicinal; Salicylates; Silver Sulfadiazine; Time Factors; Wound Healing; Wound Infection

This study has shown that Betadine cream with or without Aserbine is as easy to apply and remove as Betadine ointment plus Aserbine. With Betadine cream there is as good as and in some instances better healing than with Betadine ointment/Aserbine in the topical treatment of burns. However, the addition of a necrolytic cream to Betadine cream does have favourable effects on wound healing and bacterial counts. More importantly, this study suggests that Betadine cream can penetrate the wound more effectively than the Betadine ointment/Aserbine combination but that the addition of a necrolytic cream is still advantageous.

Topics: Administration, Topical; Adolescent; Adult; Aged; Benzoates; Burns; Child; Child, Preschool; Drug Combinations; Humans; Infant; Malates; Middle Aged; Ointments; Povidone; Povidone-Iodine; Salicylates; Wound Healing; Wound Infection

Topics: Burns; Humans; Necrosis; Ointments; Salicylates; Salicylic Acid; Skin

A remarkable improvement in the rate of burn healing has been achieved with a mixture of povidone-iodine ointment (Betadine) and malic, benzoic and salicylic acids (MBS) (Aserbine). A study was undertaken to compare the effects of a new povidone-iodine formulation (Betadine cream) with and without MBS with povidone-iodine ointment plus MBS. All preparations were easy to apply and were readily removed, causing only mild discomfort on application in the majority of cases. A significant difference in healing times was observed between povidone-iodine cream and povidone-iodine cream plus MBS. There was also a significant difference in the decrease in the number of positive bacterial cultures between these two treatments. This applied to both superficial and deep burns. No skin sensitivity reactions were reported with any of the preparations. The addition of MBS to povidone-iodine cream did not produce as significant an improvement in results as its addition to povidone-iodine ointment.

Topics: Administration, Topical; Adolescent; Adult; Anti-Infective Agents, Local; Benzoates; Burns; Drug Combinations; Humans; Malates; Ointments; Povidone; Povidone-Iodine; Salicylates; Time Factors; Wound Healing; Wound Infection

Experience with the treatment of 82 burned patients in isolation wards with the infrared radiation has shown the level of energy losses in these patients to be lower. the incidence of infectious complications to be less, the course of the disease to be better and terms of the treatment shorter than those in patients with similar burn surfaces treated by a bandage method. An automatic regulation of the intensity of infrared radiation gave the individual treatment in accordance with the metabolism level of the patient.

Topics: Adolescent; Adult; Body Temperature Regulation; Burns; Combined Modality Therapy; Debridement; Humans; Infrared Rays; Middle Aged; Ointments; Oxygen Consumption; Patient Isolators; Salicylates; Salicylic Acid; Skin Transplantation; Wound Healing

Topics: Acute Disease; Adult; Burns; Humans; Male; Ointments; Salicylates

Topics: Burns; Drug Combinations; Humans; Lactates; Lactic Acid; Ointments; Premedication; Salicylates; Salicylic Acid; Skin Transplantation; Surgical Flaps; Wound Healing

Topics: Adolescent; Adult; Aged; Burns; Debridement; Environment, Controlled; Female; Humans; Male; Middle Aged; Necrosis; Ointments; Patient Isolators; Salicylates; Salicylic Acid

Topics: Adolescent; Adult; Aged; Benzoates; Burns; Dermatologic Surgical Procedures; Humans; Middle Aged; Necrosis; Salicylates; Skin

Acerbine has been available for clinical trial since three years ago. Promotion of epithelialization, as well as antiphlogistic, antibacterial and fungicidal actions have been attributed to this preparation. This paper presents a critical appraisal of our own results with Acerbine; initial scepsis was soon dispelled by the evident efficacy of this preparation, both in the form of a lotion and ointment, and its wide scope of application. Moreover, our own studies revealed an excellent effect on keloids, which became smoother and visibly paler. A very good prophylactic and curative effect was observed in respect to all types of skin transplantation. So far Acerbine has been successfully applied in 117 patients who have completed their course of treatment. Acerbine is being currently employed in the case of 16 further patients who are still in hospital. No untoward side effects were recorded. Our findings confirm the opinion of other authors that hospitalization is shortened by the use of this preparation. The availability, more recently, of the new preparation in form of an ointment enables treatment to be continued on an ambulant basis or at home in many cases. Certain new fiies. The results of further explorative investigations into these aspects are under review at present.

Topics: Adolescent; Adult; Benzoates; Burns; Child; Child, Preschool; Drug Combinations; Explosions; Facial Injuries; Glycols; Humans; Infant; Malates; Male; Ointments; Salicylates; Solutions; Wound Healing

Topics: Bandages; Bulgaria; Burns; Child; Child, Preschool; Germany, East; Humans; Infant; Infant, Newborn; Necrosis; Preoperative Care; Salicylates; Time Factors

Topics: Administration, Topical; Adolescent; Adult; Burns; Burns, Chemical; Child; Humans; Male; Middle Aged; Ointments; Salicylates; Time Factors; Wound Healing

Topics: Animals; Benzyl Compounds; Burns; Capillary Permeability; Carbon; Ethylenediamines; Female; Histamine H1 Antagonists; Male; Pyridines; Salicylates; Sheep; Veins

Topics: Adrenal Gland Diseases; Alkalosis; Amino Acids; Burns; Diabetes Insipidus; Diarrhea; Diet, Sodium-Restricted; Dietary Fats; Dietary Proteins; Diuretics; Endocrine System Diseases; Gastrointestinal Diseases; Glucose; Humans; Infusions, Parenteral; Kidney Diseases; Parenteral Nutrition; Salicylates; Sodium Chloride; Vomiting; Water-Electrolyte Balance

Topics: Adolescent; Adult; Burns; Female; Humans; Inflammation; Male; Methods; Middle Aged; Ointments; Salicylates; Samarium

Topics: Anti-Infective Agents, Local; Benzoates; Biguanides; Burns; Child, Preschool; Humans; Infection Control; Malates; Salicylates

Topics: Animals; Blood Vessels; Burns; Capillary Permeability; Chlorpromazine; Digoxin; Diphenhydramine; Indomethacin; Inflammation; Male; Permeability; Promethazine; Quinine; Rats; Salicylates; Strophanthins; Tissue Extracts; Turpentine

Topics: Animals; Burns; Debridement; Ointments; Pancreatin; Papain; Pyruvates; Rabbits; Salicylates

Topics: Aminocaproates; Animals; Aprotinin; Aspirin; Burns; Enzyme Therapy; Male; Mice; Phenylbutazone; Salicylates; Shock

Topics: Adult; Analgesics; Anti-Bacterial Agents; Benzoates; Blood Transfusion; Burns; Child; Child, Preschool; Female; Humans; Infant; Malates; Male; Plasma Substitutes; Propylene Glycols; Salicylates

The causes of injury to 17,141 children brought to the emergency department of a large pediatric hospital in one year were studied. The leading causes of injury were: falls, 5682; cuts or piercings, 1902; poisonings, 1597; and transportation accidents, 1368. Included in these are 587 falls on or down stairs, 401 cuts due to glass, 630 poisonings from household or workshop substances, 510 poisonings from salicylate tablets, and 449 accidents involving bicycles or tricycles. Other findings included 333 injuries to fingers or hands in doors, usually car doors; 122 instances of pulled arms; 384 ingestions and 53 inhalations of foreign bodies; 60 alleged sexual assaults, 58 chemical burns, 127 wringer injuries, and four attempted suicides. A rewarding opportunity in accident prevention exists for hospitals that undertake to compile and distribute pertinent source data.

Topics: Accident Prevention; Accidents; Accidents, Traffic; Adolescent; Biometry; Bites and Stings; Burns; Burns, Chemical; Canada; Child; Craniocerebral Trauma; Emergency Service, Hospital; Eye Injuries; Foreign Bodies; Hospitals, Pediatric; Humans; Infant; Male; Poisoning; Salicylates; Sports Medicine; Statistics as Topic

Topics: Blood Transfusion; Burns; Child; Chlorides; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infusions, Parenteral; Intestinal Obstruction; Kidney; Peritonitis; Potassium; Pyloric Stenosis; Salicylates; Sodium; Toxicology; Water; Water-Electrolyte Balance

Topics: Animals; Burns; Capillary Permeability; Histamine H1 Antagonists; Isoflurophate; Rats; Salicylates