salicylates and Burns--Chemical

Salicylic acid and its derivatives are extensively used medications for the treatment of systemic and local diseases. However, injudicious use of aspirin as well as other derivatives of salicylic acid, may cause systemic and oral complications such as mucosal burns and oral ulcers. In children, topical administration of these drugs, even in small dosages, may cause adverse reactions. This report shows a case of an 8 year old boy with G6PD deficiency, who had a mucosal burn caused by application of a cholinsalicylate paste. Three days later, the child developed oral ulcers, malaise and fever. The present case is characteristic of the enigmatic nature of the etiology and diagnosis of oral lesions, and the possible connection between cholinsalicylate systemic absorption and hemolytic anemia is discussed.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Burns, Chemical; Child; Choline; Dental Care for Chronically Ill; Drug Combinations; Glucosephosphate Dehydrogenase Deficiency; Humans; Male; Mouth Mucosa; Oral Ulcer; Salicylates

Most personal defense sprays contain o-chlorobenzylidene malononitrile (CS), w-chloroacetophenone (CN), oleoresin capsicum (OC), or a combination of these ingredients as the active agent. They are designed to incapacitate by causing acute ocular irritation, lacrimation, conjunctivitis, blepharospasm, and mild to moderate respiratory distress.. To assess the ocular effects of sprays containing OC as the active agent. Snellen visual acuities and anterior segment appearances of 22 police officers were determined before and after spray exposure. To assess the effects of OC spray contamination on soft contact lenses, four brands of lenses were sprayed and cleaned twice with an alcohol-based cleaner. Gas chromatography was used to search for residual OC in the lenses.. All officers experienced intense blepharospasm, lacrimation, conjunctivitis, and incapacitation as the result of spray exposure. Acute effects lasted about 5 to 10 min, with relatively complete recovery occurring in about 30 to 60 min. All had significant conjunctivitis, and some had water-drop-shaped corneal defects that stained with fluorescein. These defects resolved within 24 hours without treatment. OC residue was found to be present in the soft lenses that had been sprayed and cleaned twice.. Optometrists can manage uncomplicated spray exposure patients by directing at-home irrigation with water, and following up with an in-office examination. Soft lenses contaminated by OC spray should be discarded.

Topics: Aerosols; Blepharospasm; Burns, Chemical; Capsicum; Chromatography, Gas; Conjunctivitis; Contact Lenses; Eye Burns; Eye Protective Devices; Humans; Irritants; Lacrimal Apparatus Diseases; Plant Extracts; Plants, Medicinal; Salicylates; Visual Acuity

The authors studied experimentally the morphological changes of injuries and the surrounding areas after a skin chemical injury caused by sodium hydroxide, sulphuric acid and chlorhydric acid under the influence of acidic necrolytics--40% benzoic acid and 40% salycilic acid in unguentus. The necrolytics are applied on the injured areas immediately upon getting the wound or on the 4th day thereafter, while the morphological study is carried out after getting off the necrosis. It has been established that the necrolysis in the case of sodium hydroxide was not effected by the 28th day. The processes in the tissues upon acidic injuries do not differ from the spontaneous healing process.

Topics: Animals; Benzoates; Benzoic Acid; Burns, Chemical; Debridement; Drug Evaluation, Preclinical; Necrosis; Ointments; Salicylates; Salicylic Acid; Skin; Time Factors

A case of an unusual caustic ingestion involving Compound W, an over the counter wart remover is presented. Chemical burns of the tongue, pharynx and larynx developed. The active ingredient in this preparation: salicylic acid in a flexible collodion vehicle produces caustic injury through a keratolytic action, which may be enhanced by the presence of collodion.

Topics: Administration, Oral; Adolescent; Burns, Chemical; Colloids; Epiglottis; Humans; Male; Pharynx; Salicylates; Salicylic Acid; Suicide, Attempted; Tongue

Topics: Administration, Topical; Adolescent; Adult; Burns; Burns, Chemical; Child; Humans; Male; Middle Aged; Ointments; Salicylates; Time Factors; Wound Healing

The causes of injury to 17,141 children brought to the emergency department of a large pediatric hospital in one year were studied. The leading causes of injury were: falls, 5682; cuts or piercings, 1902; poisonings, 1597; and transportation accidents, 1368. Included in these are 587 falls on or down stairs, 401 cuts due to glass, 630 poisonings from household or workshop substances, 510 poisonings from salicylate tablets, and 449 accidents involving bicycles or tricycles. Other findings included 333 injuries to fingers or hands in doors, usually car doors; 122 instances of pulled arms; 384 ingestions and 53 inhalations of foreign bodies; 60 alleged sexual assaults, 58 chemical burns, 127 wringer injuries, and four attempted suicides. A rewarding opportunity in accident prevention exists for hospitals that undertake to compile and distribute pertinent source data.

Topics: Accident Prevention; Accidents; Accidents, Traffic; Adolescent; Biometry; Bites and Stings; Burns; Burns, Chemical; Canada; Child; Craniocerebral Trauma; Emergency Service, Hospital; Eye Injuries; Foreign Bodies; Hospitals, Pediatric; Humans; Infant; Male; Poisoning; Salicylates; Sports Medicine; Statistics as Topic