salicylates and Bone-Diseases

Topics: Aged; Analgesics; Aspirin; Bone Diseases; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Joint Diseases; Lysine; Middle Aged; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Pain; Placebos; Salicylates; Stomach

Fosfosal or 2-phosphonoxybenzoic acid is a new analgesic drug, whose analgesic activity and side effects have been determined in a double blind clinical study in comparison with placebo. The study has been done with 60 outpatients, of both sexes, which suffered musculoskeletal and arthritic pains. Patients were treated with fosfosal or placebo for eight days. The daily dose of fosfosal was 1 gram three times a day, once every 6-8 hours. The results obtained show that fosfosal has a clear analgesic activity, statistically significant versus placebo in all the parameters that were measured: pain severity, activity impairment and insomnia. The overall evaluation of the group of patients treated with fosfosal showed a marked improvement with a difference statistically significant with respect to the control group treated with placebo (p less than 0.001). The distribution of results in the fosfosal treated group was as follows: poor, 1; regular, 8; good, 10 and excellent, 6. The distribution in the placebo group was as follows: poor, 15; regular, 3; good, 2 and excellent, 0. The marked analgesic activity, the absence of side effects and the excellent gastric tolerance suggest that fosfosal is a promising new analgesic drug useful for the treatment of painful syndromes of several etiologies.

Topics: Adult; Aged; Analgesics; Arthritis; Bone Diseases; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Pain; Salicylates

Topics: Aged; Bone Diseases; Clinical Trials as Topic; Double-Blind Method; Female; Hip Joint; Humans; Indomethacin; Joint Diseases; Male; Middle Aged; Random Allocation; Salicylates

Topics: Acute Disease; Arthritis, Rheumatoid; Bone Diseases; Clinical Trials as Topic; Drug Synergism; Humans; Osteoarthritis; Osteochondritis; Osteoporosis; Pain; Penicillins; Placebos; Pleurisy; Prednisolone; Rheumatic Diseases; Rheumatic Fever; Salicylates; Spondylitis

Topics: Administration, Topical; Adult; Bone Diseases; Drug Combinations; Female; Humans; Iontophoresis; Male; Muscular Diseases; Nicotinic Acids; Plant Extracts; Salicylamides; Salicylates

An open study was carried out in general practice to assess the analgesic effectiveness, tolerance and side-effects of salsalate when given at a dosage of 3 g per day for 6 weeks. Sixty-six patients who were known long-term analgesic users were treated: they included 16 with active inflammatory disease of rheumatoid type, 20 with degenerative joint disease, and 27 with other musculo-skeletal conditions. Three patients were withdrawn during the study because of gastro-intestinal upset. Assessments, using rating scale scores, were made pre-trial and at 2-weekly intervals of joint pain, other musculo-skeletal pain, and duration of morning stiffness. The results showed that there was marked improvement in joint pain and morning stiffness, particularly in those patients with inflammatory joint disease. Improvement in musculo-skeletal discomfort was less evident. Side-effects were reported on 24 occasions, the most frequent being dyspepsia. Faecal occult blood tests showed that there were 7 patients with probable blood loss during treatment, 4 of them, however, had no other clinical signs or symptoms of gastrointestinal intolerance.

Topics: Bone Diseases; Chronic Disease; Female; Humans; Male; Middle Aged; Muscular Diseases; Occult Blood; Pain; Salicylates

Topics: Adult; Aged; Bone Diseases; Cadmium Poisoning; Chromatography, Gel; Electrophoresis, Disc; Humans; Middle Aged; Poisoning; Proteinuria; Salicylates; Trichloroacetic Acid

Topics: Adult; Age Factors; Anemia; Bone Diseases; Bone Resorption; Calcium; Fluorides; Glucocorticoids; Hepatomegaly; Histamine; Histamine Release; Humans; Hydroxyproline; Male; Mast Cells; Opium; Osteoporosis; Peptic Ulcer; Phosphorus; Protein-Losing Enteropathies; Radiography; Salicylates; Serotonin; Sex Factors; Splenomegaly; Urticaria Pigmentosa

Topics: Bone Diseases; Glycosaminoglycans; Humans; Muscular Diseases; Salicylates; Tissue Extracts

Topics: Accidents; Adrenal Cortex; Bone Diseases; Drug Combinations; Glycosaminoglycans; Humans; Joint Diseases; Salicylates; Salicylic Acid; Tissue Extracts

Topics: Blood Glucose; Bone Diseases; Humans; Musculoskeletal System; Salicylates