salicylates and Blood-Coagulation-Disorders

Topics: Adrenal Cortex Hormones; Antihypertensive Agents; Antineoplastic Agents; Barbiturates; Blood Coagulation Disorders; Cardiac Glycosides; Drug Combinations; Hemostasis; Hormones; Humans; Penicillins; Pyrazoles; Salicylates

Topics: Acetazolamide; Acid-Base Equilibrium; Amino Acids; Bicarbonates; Blood Coagulation Disorders; Child; Exchange Transfusion, Whole Blood; Gastric Lavage; Glucose; Humans; Ipecac; Ketones; Peritoneal Dialysis; Poisoning; Potassium; Renal Dialysis; Salicylates; Serum Albumin; Water-Electrolyte Balance

Topics: Antihypertensive Agents; Blood Coagulation Disorders; Cardiovascular Diseases; Coumarins; Drug Interactions; Epilepsy; Heparin; Humans; Hypertension; Lidocaine; Mental Disorders; Pharmaceutical Preparations; Phenothiazines; Phenytoin; Procainamide; Salicylates

Topics: Administration, Oral; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Anticoagulants; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Factors; Clofibrate; Coumarins; Diuresis; Dogs; Heparin; Humans; Hypnotics and Sedatives; Liver Diseases; Metabolic Diseases; Phenylbutazone; Rats; Salicylates; Sulfonamides; Thrombosis; Uremia; Vitamin K

Topics: Adenine Nucleotides; Animals; Anticoagulants; Blood Coagulation Disorders; Blood Platelet Disorders; Blood Platelets; Catecholamines; Dextrans; Edetic Acid; Electrolytes; Fatty Acids; Glucose; Hormones; Humans; Platelet Adhesiveness; Salicylates; Serotonin

Topics: Blood Coagulation Disorders; Hemorrhage; Humans; Salicylates

Topics: Blood Coagulation Disorders; Hemorrhage; Humans; Salicylates

Bismuth subsalicylate (BSS) is the active ingredient in over-the-counter antacid and antidiarrheal medications. Coagulopathy in the setting of acetylsalicylic acid toxicity is well documented but not in setting of bismuth subsalicylate overuse. We present a case report of coagulopathy from BSS poisoning in a patient with underlying cirrhosis. The patient's high prothrombin time suggests inhibition of vitamin K-dependent coagulation factors. The patient had decreased factor V activity, which is responsible for converting prothrombin to thrombin. Patients with cirrhosis often have hypoprothrombinemia which may be exacerbated by salicylate-induced coagulopathy. Given the widespread use of BSS products, physicians should recognize coagulopathy as a possible manifestation of toxicity especially in patients with underlying liver disease.

Topics: Bismuth; Blood Coagulation Disorders; Chronic Disease; Female; Humans; International Normalized Ratio; Liver Cirrhosis; Middle Aged; Organometallic Compounds; Salicylates

A 17-year-old girl swallowed at least 50 Duroferon duretter. Each tablet contains ferrous sulphate equivalent to 0.1 g Fe2+. Thus, a total of 5 g Fe2+ was ingested. Vitamin K-dependent coagulation factors dropped within the next hours to very low levels. Thrombotest showed less than 3% of normal coagulation activity 8 h after oral intake. Recovery was uneventful except for laboratory evidence of transient liver damage. The rapidity by which the early coagulation deficiencies developed and the lack of evidence of disseminated intravascular coagulation suggested a direct effect of iron on coagulation factors. In vitro studies confirmed that iron in concentrations that may have been attained in vivo, altered the functional activity of several coagulation factors. Monitoring the vitamin K-dependent coagulation factors may be a simple and useful parameter in acute iron intoxication.

Topics: Acetaminophen; Adolescent; Alcohol Drinking; Blood Coagulation Disorders; Female; Humans; Iron; Iron-Dextran Complex; Leukocyte Count; Platelet Count; Prothrombin Time; Salicylates; Suicide, Attempted; Vitamin K

The hyperaggregability of platelets is remarkably important in the pathogenesis of decompression sickness. The basis of this phenomenon might consist of an excessive production of metabolites of arachidonic acid (C 20:4) whose action favours aggregation (prostaglandin endoperoxides PGG2 and PGH2 and Tromboxane A2) in respect of the synthesis of its derivatives exerting an antithrombotic action (prostacyclin I2). The antiaggregating therapy usually associated to the hyperbaric treatment involves administration of acetylsalicylic acid in low doses (3.5-5 mg/kg every three days), associated if necessary to dypyridamol. As a prophylaxis against thrombotic phenomena in "risky" subjects, a congruous dietetic assumption of polyunsaturated fatty acids is recommended, such as linoleic acid (C 18:2) and eicosapentaenoic acid (C 20:5) which are forerunners of anti-aggregating prostaglandin derivates. Hyperbaric oxygenation might finally lead to the production of lypid peroxides apt to inhibit the synthesis of PGI2. In such cases it is a rational procedure to administer vitamin E in high doses, as physiological antioxidant of lypids.

Topics: Antioxidants; Arachidonic Acid; Arachidonic Acids; Blood Coagulation Disorders; Decompression Sickness; Dipyridamole; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hyperbaric Oxygenation; Platelet Aggregation; Salicylates; Salicylic Acid; Thrombosis; Vitamin E

Not considering the complications due to anesthesia, postoperative hemorrhage is certainly the most frequent complication following tonsillectomy. When injury of a major vessel can be ruled out as the cause of bleeding, a discrete disturbance of hemostasis must be considered. These are mainly thrombocytopathies or a pathologically increased fibrinolysis which were not detected by routine tests and the past history. Preoperatively one should ask for more or less regular use of analgesics containing salicylates which should not be administered postoperatively. The worst attitude is case of a post-tonsillectomy hemorrhage is to do nothing or to rely on non-specific measures hoping that the bleeding will stop anyway.

Topics: Aged; Blood Coagulation Disorders; Child; Fibrinolysis; Hemorrhage; Humans; Male; Salicylates; Taste Disorders; Tonsillectomy

Topics: Adenosine Diphosphate; Blood Coagulation Disorders; Epinephrine; Female; Gastrointestinal Hemorrhage; Humans; Infant, Newborn; Maternal-Fetal Exchange; Platelet Adhesiveness; Pregnancy; Salicylates; Vitamin K

Topics: Adenine Nucleotides; Adult; Aspirin; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Blood Transfusion; Centrifugation; Collagen; Diagnosis, Differential; Epinephrine; Female; Glass; Hemorrhagic Disorders; Humans; Male; Middle Aged; Salicylates; Serotonin; Thrombin; Trypsin; von Willebrand Diseases

Topics: Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelet Disorders; Blood Protein Disorders; Humans; Kidney Failure, Chronic; Leukemia; Liver Diseases; Salicylates; Thrombocythemia, Essential; Uremia

Topics: Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Humans; Propylthiouracil; Prothrombin; Salicylates; Vitamin K; Vitamin K Deficiency