salicylates and Ascorbic-Acid-Deficiency

The effect of certain drugs on nutrient metabolism is discussed. Antituberculotic drugs such as INH and cycloserine interfere with vitamin B6 metabolism and may produce a secondary niacin deficiency. Oral contraceptives interfere with the metabolism of folic acid and ascorbic acid, and in cases of deficient nutrition, they also seem to interfere with riboflavin. Anticonvulsants can act as folate antagonists and precipitate folic acid deficiency. Therefore, in some cases, supplementation with folate has been recommended simultaneously with anticonvulsant therapy. Cholestyramine therapy has been associated with malabsorption of vitamins; several reports suggest that cholestyramine affects absorption of the fat-soluble vitamins K and D and, in addition, may alter water-soluble vitamins, including folic acid. The study of the interaction of drugs and nutrients is an area that deserves a greater attention in the future, especially in groups where nutrient deficiencies may be prevalent.

Topics: Anticonvulsants; Antitubercular Agents; Ascorbic Acid Deficiency; Avitaminosis; Cholestyramine Resin; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Folic Acid Deficiency; Humans; Nutritional Physiological Phenomena; Salicylates; Vitamin B 6 Deficiency

Topics: Age Factors; Alcohol Drinking; Animals; Anti-Inflammatory Agents; Ascorbic Acid Deficiency; Aspirin; Blood Group Antigens; Female; Food; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Hydrogen-Ion Concentration; Male; Nutritional Physiological Phenomena; Particle Size; Permeability; Prostaglandins; Regional Blood Flow; Salicylates; Sex Factors; Stomach Diseases; Stomach Ulcer; Structure-Activity Relationship

Topics: Animals; Anticoagulants; Ascorbic Acid Deficiency; Aspirin; Cats; Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Hemorrhagic Disorders; Histamine; Humans; Occult Blood; Pepsin A; Rats; Salicylates; Time Factors; Vagotomy; Vagus Nerve; von Willebrand Diseases