salicylates and Arterial-Occlusive-Diseases

Triflusal is an irreversible inhibitor of platelet cyclooxygenase. Triflusal significantly reduced the incidence of nonfatal myocardial infarction in patients with unstable angina. Antithrombotic properties have also been demonstrated in patients with aortocoronary vein grafting, coronary angioplasty, peripheral arteriopathy and cerebrovascular disease. Moreover, in diabetic patients it has a protective effect against retinal microangiopathy, improves renal flow and reduces proteinuria. The drug has a high tolerability and has low incidence of side effects, with prevalence of gastrointestinal and skin disorders. Because of its demonstrated effectiveness and its good handling, we decided to use Triflusal in treatment of geriatric patients with peripheral arteriopathy. Often these patients have a diffused arteriopathic disease which can be associated with chronic diseases. For this reason there are severe problems of compliance due to contemporary administration of several drugs; so the utilization of effective drugs, without side effects, promotes a safer clinical management of patients.. Between April 2000 and March 2001, we treated with Triflusal 70 patients, over 65 years old, with peripheral arteriopathy. The group comprises patients who had undergone traditional vascular surgery, or endovascular surgery and patients treated exclusively with drug therapy. During the follow-up we obser-ved the possible clinical development of side effects of the drug reported in the literature (nausea, vomiting, etc.).. One patient, already affected by gastroduodenal disease, suspended the therapy because of severe epigastric burning.. The follow-up of the patients goes on in order to evaluate the tolerability and handling of Triflusal, observing a larger number of patients.

Topics: Age Factors; Aged; Aged, 80 and over; Arterial Occlusive Diseases; Female; Follow-Up Studies; Humans; Male; Patient Compliance; Platelet Aggregation Inhibitors; Risk Factors; Salicylates; Time Factors

Topics: Adult; Aged; Arterial Occlusive Diseases; Epoprostenol; Forearm; Humans; Imidazoles; Indomethacin; Male; Middle Aged; Prostaglandins; Salicylates; Veins

Topics: Arterial Occlusive Diseases; Coumarins; Humans; Patient Acceptance of Health Care; Postoperative Complications; Salicylates

A review is given on systemically applied drugs, which may cause vascular disturbances of the retina with possible irreversible involvment of the ocular function. Based upon personal observations and reports in the literature a series of drugs with such side effects is reported. In particular, besides retrolental fibroplasia and complications which can be induced by oestrogens, drugs are described, which on the basis of an allergic reaction may produce retinal haemorrhages or occlusions of retinal blood vessels.

Topics: Adult; Arterial Occlusive Diseases; Chloramphenicol; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Estrogens; Female; Humans; Middle Aged; Phenylbutazone; Retinal Diseases; Retinal Hemorrhage; Retinal Vessels; Salicylates; Sulfonamides