salicylates and Argyria

Topics: Adenocarcinoma; Aged; Argyria; Diarrhea; Drug Combinations; Humans; Male; Rectal Neoplasms; Salicylates; Silver; Silver Compounds; Skin Pigmentation

One case of agryria is reported that developed after a long-term administration of adsorgan in a patient with dyspeptic manifestations after cholecystectomy. The developed skin syndrome -- ashen-grey discolorization of the skin of the face and bare parts of the hands and the neurological symptoms -- right monoparesis and vestibular-disturbances with clinical manifestations of chronic cholangiohepatitis, pancreatitis and gastroduodentitis -- provided considerable diagnostic difficulties. The problem of argyria is discussed as a state of intoxication in chronic use of silver-containing medicaments. The necessity of differentiating argyria by the internists is stressed upon in order to avoid it as a complication in the administration of drugs-containing silver, adsorgan resp., being applied in the physician's practice.

Topics: Adult; Argyria; Colloids; Drug Combinations; Humans; Male; Salicylates; Silver; Time Factors