salicylates and Angioedema

The first component of the classical pathway of the complement system, C1 is regulated by a serum protein, the C1-esterase inhibitor (C1-INH). Deficiency of this protein leads to the release of vasoactive mediators (C2 kinin and bradykinin) that increase vascular permeability and can induce edema formation in subcutaneous and submucosal tissues. The genetic variant of C1-INH deficiency is inherited as an autosomal dominant trait and causes hereditary angioneurotic edema. The acquired form of C1-INH deficiency is characterized by similar manifestations and can occur in association with lymphoproliferative diseases, malignancy, immune disorders, and infections. The authors present a case of acquired C1-INH deficiency in a patient with Helicobacter pylori infection. Complete eradication of this pathogen was followed by the resolution of symptoms and normalization of serum complement levels. It seems therefore probable that in this patient, acquired C1-INH deficiency was related to Helicobacter pylori infection. To our best knowledge, no similar observations have been published so far. Specific immune reactions are important contributing factors in H. pylori. Excessive consumption of complement by antibodies directed against H. pylori is a potential cause of C1-INH deficiency observed in our case.

Topics: Adult; Angioedema; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Ciprofloxacin; Complement C1 Inactivator Proteins; Drug Therapy, Combination; Female; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Salicylates; Time Factors

Not only is urticaria a condition of disparate cause, but it also may be produced through the action of one or more of a long list of chemical mediators. This article discusses some of the accepted procedures in the evaluation of patients with urticaria, which includes not only categorization but also a search for the sources of aggravation and laboratory testing to confirm the clinical diagnosis. An example of a printed history form is included, which comprises questions that hopefully will help to identify aggravating factors as well as potential causes.

Topics: Angioedema; Aspirin; Cold Temperature; Coloring Agents; Dermatitis, Contact; Food Preservatives; Hot Temperature; Humans; Pressure; Salicylates; Sunlight; Tyramine; Urticaria; Vasculitis; Water; Yeasts

Urticaria and angio-oedema are a symptom complex covering a wide range of clinical disorders. Specific types are now well described, and it appears that many cases of idiopathic chronic urticaria which make up the vast majority of patients referred for assessment are due to intolerance to natural salicylates, preservatives and colouring agents. There is, therefore, an urgent need for legislation to enforce the clear identification of these chemicals in processed food and drugs.

Topics: Angioedema; Cold Temperature; Drug-Related Side Effects and Adverse Reactions; Food Coloring Agents; Food Preservatives; Histamine H2 Antagonists; Humans; Salicylates; Urticaria

Topics: Angioedema; Blood Platelets; Fibrinolysin; Humans; Indoles; Inflammation; Kinins; Pyrazoles; Salicylates

Topics: Adolescent; Adult; Aged; Ampicillin; Analgesics; Anaphylaxis; Angioedema; Anti-Bacterial Agents; Barbiturates; Child; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; Erythema; Exanthema; Female; Humans; Infant; Male; Middle Aged; Penicillins; Photosensitivity Disorders; Salicylates; Stevens-Johnson Syndrome; Sulfonamides; Urticaria

Topics: Angioedema; Animals; Blood Coagulation Factors; Bradykinin; Carboxypeptidases; Carcinoid Tumor; Catecholamines; Chemical Phenomena; Chemistry; Colchicine; Complement System Proteins; Female; Glucocorticoids; Guinea Pigs; Haplorhini; Humans; Inflammation; Kallidin; Kallikreins; Kidney; Kinins; Muscle Contraction; Phenothiazines; Rats; Salicylates; Sheep; Shock, Septic; Stimulation, Chemical; Uterus; Vascular Diseases; Vascular Resistance; Vasodilator Agents

Topics: Aminopyrine; Angioedema; Anti-Bacterial Agents; Barbiturates; Dermatitis, Contact; Drug Hypersensitivity; Erythema; Erythema Multiforme; Erythema Nodosum; Exanthema; Humans; Hungary; Pertussis Vaccine; Purpura; Quinine; Salicylates; Smallpox Vaccine; Stevens-Johnson Syndrome; Sulfonamides; Tetanus Antitoxin; Tranquilizing Agents; Vaccinia