salicylates and Anaphylaxis

Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Reactions; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Epinephrine; Fever; Histamine H1 Antagonists; Humans; Jaundice; Lupus Erythematosus, Systemic; Prednisone; Salicylates; Serum Sickness; Skin Tests; Thrombocytopenia

Topics: Administration, Topical; Anaphylaxis; Camphor; Dexamethasone; Drug Hypersensitivity; Glycols; Humans; Menthol; Niacin; Ointments; Salicylamides; Salicylates

Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Bismuth; Drug Hypersensitivity; Humans; Immunoglobulin E; Male; Organometallic Compounds; Reproducibility of Results; Salicylates; Skin Tests; United States; Urticaria

Topics: Anaphylaxis; Diflunisal; Female; Humans; Middle Aged; Salicylates

In 282 patients presenting with adverse reactions to mild analgesics, prick tests were performed with components of analgesic drugs; in some of them, commercial preparations were also tested. In 19 patients (7%), a total of 40 conclusively positive immediate reactions was found: there were 22 reactions to pyrazolone derivatives, 14 reactions to commercial preparations, and one singular reaction to phenacetin, phenobarbital, carbromal and vitamin B1, respectively. Cross-sensitivity to different pyrazolone derivatives was observed in only 5 of 15 patients with a positive reaction to at least one of these substances. One of the patients with a positive immediate reaction and 2 further individuals developed positive test reactions after 4 to 24 h. Within 117 patients who gave a clear-cut history of anaphylactoid reactions to mild analgesics, there were conclusive immediate prick test results in 15 cases (13%). In these patients, the diagnostic relevance of the prick test increased with the severity of symptoms in the history, and a conclusive immediate reaction was obtained in 25% of those with full shock in the history.

Topics: Adolescent; Adult; Aged; Aminophenols; Analgesics; Anaphylaxis; Child; Drug Eruptions; Female; Humans; Hypersensitivity, Immediate; Intradermal Tests; Male; Middle Aged; Pyrazoles; Pyrazolones; Salicylates; Skin Tests

Rats were intraperitoneally immunized with ovalbumin (egg albumin) with incomplete Freund's adjuvant, and the effect of intravenous challenge with ovalbumin on the intestinal blood flow was measured by means of hydrogen clearance method. The intestinal blood flow was significantly reduced by the antigen challenge in ovalbumin-immunized rats compared to the non-immunized rats. However, no significant change was observed on the intestinal blood flow in rats without challenge of the antigen. Moreover, the blood flow reduction was not found in ovalbumin-immunized rats challenged with bovine gamma-globulin. The effect was maintained for at least 16 weeks after the third immunization, but the reduced blood flow was gradually restored to the control level. The decrease in both blood flow and absorption of salicylic acid was recovered by nearly 70% of the control level when high dose of theophylline or caffeine was administered intravenously. In the case of gastric absorption during systemic anaphylaxis, similar results were also obtained by means of in situ loop technique. The decreased absorption of salicylic acid from the rat stomach also correlate with the reduced gastric blood flow. These findings suggest that the decreased absorption of salicylic acid from the gastrointestinal tract might be affected by the reduced blood flow during systemic anaphylaxis.

Topics: Anaphylaxis; Animals; Cattle; gamma-Globulins; Immunity; Intestinal Absorption; Intestines; Male; Ovalbumin; Pharmaceutical Preparations; Rats; Rats, Inbred Strains; Regional Blood Flow; Salicylates; Salicylic Acid; Stomach; Time Factors

Rats were immunized by intraperitoneal injection of ovalbumin (egg albumin) emulsified in Freund's incomplete adjuvant, and then the effect of an intravenous challenge with ovalbumin on salicylic acid absorption from the small intestine was examined by means of an in situ recirculation technique. The disappearance of salicylic acid from the luminal solution was significantly decreased in rats treated with ovalbumin compared with control groups treated with saline. The decreased absorption of salicylic acid in ovalbumin-immunized rats was related to the anti-ovalbumin antibody responses examined by passive cutaneous anaphylactic reactions. On the other hand, the decreased absorption of salicylic acid was not found in ovalbumin-immunized rats challenged intravenously with bovine gamma-globulin. Similar results were also noted in rats immunized via the footpads with ovalbumin. However, no significant change was observed in the intestinal absorption of salicylic acid in normal (nonimmunized) rats challenged intravenously with ovalbumin. Furthermore, intestinal absorption of sulfadimethoxine and sulfanilamide was significantly decreased during systemic anaphylaxis, whereas no change was observed in the absorption of sulfisoxazole, quinine, sulfanilic acid, and phenolsulfonphthalein. This suggests that the intestinal absorption of rapidly absorbed drugs, including salicylic acid, is more sensitive to systemic anaphylaxis than that of poorly absorbed drugs.

Topics: Anaphylaxis; Animals; gamma-Globulins; Injections, Intravenous; Intestinal Absorption; Male; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid

Previous studies have demonstrated the decrease of intestinal salicylic acid absorption in ovalbumin-immunized rats during systemic anaphylaxis. In the present study, the mechanism whereby systemic anaphylaxis interferes with the intestinal absorption of salicylic acid was studied. The pH of the luminal solution was not affected by the intravenous challenge with ovalbumin. A significant increase of the intraluminal protein was observed in rats under systemic anaphylaxis. However, there was no significant difference between ovalbumin-treated rats and saline-treated ones on the binding of salicylic acid with intraluminal macromolecular substances. Enhanced mucus release in the perfusate was also observed in sensitized rats but the extent of decrease in absorption of salicylic acid did not correlate with the increase in amount of the intraluminal mucus in the same animals. In addition, no significant effect was observed on the uptake by the intestinal everted sac of rats with systemic anaphylaxis. These findings suggested that mucus as well as protein is not responsible for the decrease of absorption of salicylic acid induced by systemic anaphylaxis. From these observations, it would appear that the circulatory changes in the gastrointestinal tract may play an important role in the decreased absorption of salicylic acid during systemic anaphylaxis.

Topics: Anaphylaxis; Animals; Evans Blue; Immunity; Intestinal Absorption; Male; Mucus; Ovalbumin; Permeability; Pharmaceutical Preparations; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid

Low doses of sodium or copper salicylate, administered at the same time as agents producing the anaphylactoid reaction in rats, significantly enhanced the onset, height and duration of the responses. The enhancement occurred after intraperitoneal or local administration. Enhanced transport of the high molecular weight agents into the bloodstream is suggested. However, the salicylates did not enhance histamine release from isolated peritoneal mast cells of rats induced by dextran and phosphatidyl serine.

Topics: Adjuvants, Immunologic; Anaphylaxis; Animals; Dextrans; Dose-Response Relationship, Immunologic; Male; Rats; Rats, Inbred Strains; Salicylates

Topics: Anaphylaxis; Animals; Dextrans; Drug Synergism; Injections, Intraperitoneal; Intestinal Absorption; Male; Rats; Rats, Inbred Strains; Rectum; Salicylates; Time Factors

Rats were intraperitoneally immunized with bovine gamma-globulin (BGG) emulsified in incomplete Freund's adjuvant. Intestinal absorption of salicylic acid from the rat small intestine was examined by means of in situ recirculation technique. The disappearance of salicylic acid from the luminal solution was significantly decreased in rats challenged intravenously with BGG compared to saline as control. A significant decrease in absorption of salicylic acid was noted in rats immunized twice and three times, but not in rats immunized only once. The effect was maintained for at least 5 weeks after the third immunization, whereas it disappeared within 10 weeks. In normal rats, the decreased absorption of salicylic acid by the intravenous challenge with BGG was hardly observed at all. These findings suggest that the intestinal absorption of salicylic acid may be affected by systemic anaphylaxis in actively immunized rats.

Topics: Anaphylaxis; Animals; gamma-Globulins; Immunization; Intestinal Absorption; Male; Rats; Salicylates

A variety of derivatives of acetylsalicylic and salicylic acid have been investigated for their immunogenic properties in guinea pigs including salicylsalicylic acid (SSA), acetylsalicylsalicylic acid (ASSA), disalicylide (DI), trisalicylide (TRI), acetylsalicylic acid paracetamol ester (ASPE) and acetylsalicylic acid guajacol ester (ASGE). Contact sensitivity could be elicited by the sensitizing agent, however, with acetylsalicylic acid anhydride (ASAN) a more pronounced contact reaction could consistently be observed. Systemic anaphylactic reactions elicited by intravenous injection of N-salicyloyl bovine serum albumin could only be induced by ASAN, DI, TRI and ASSA, whereas SSA, ASPE and ASGE did not induce an anaphylactic state at a comparable dose level. From these results it is anticipated that all aryl esters of acetylsalicylic or salicylic acid are immunogenic when applied intradermally, leading to a N-salicyloyl specific immune response.

Topics: Acetylation; Anaphylaxis; Anhydrides; Animals; Aspirin; Carboxylic Acids; Cross Reactions; Dermatitis, Contact; Esters; Guinea Pigs; Immunization; Salicylates; Serum Albumin, Bovine

Topics: Agranulocytosis; Ampicillin; Anaphylaxis; Animals; Anti-Bacterial Agents; Antigens; Autoradiography; Drug Eruptions; Drug Hypersensitivity; Humans; Immune Sera; Immunodiffusion; Immunoglobulin E; Iodine Isotopes; Penicillins; Pyrazoles; Salicylates; Skin Diseases; Sulfonamides; Swine; Thrombocytopenia; Urticaria

Topics: Acetylcholine; Anaphylaxis; Anesthesia, Intravenous; Animals; Atropine; Blood Pressure; Chickens; Chloral Hydrate; Chlorpheniramine; Epinephrine; Female; Flumethasone; Hexamethonium Compounds; Histamine; Norepinephrine; p-Methoxy-N-methylphenethylamine; Pentobarbital; Poultry Diseases; Promethazine; Salicylates; Serum Albumin, Bovine; Tripelennamine

Topics: Adolescent; Adult; Aged; Ampicillin; Analgesics; Anaphylaxis; Angioedema; Anti-Bacterial Agents; Barbiturates; Child; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; Erythema; Exanthema; Female; Humans; Infant; Male; Middle Aged; Penicillins; Photosensitivity Disorders; Salicylates; Stevens-Johnson Syndrome; Sulfonamides; Urticaria

Topics: Adrenal Cortex Hormones; Aminocaproates; Anaphylaxis; Animals; Chlorpromazine; Guinea Pigs; Heparin; Histamine H1 Antagonists; Mast Cells; Peritoneum; Phenylbutazone; Salicylates

Topics: Anaphylaxis; Animals; Antibodies; Atropine; Bradykinin; Chlorpheniramine; Haplorhini; Histamine H1 Antagonists; Histamine Release; Hydrocortisone; Ileum; Immunoglobulin E; Lysergic Acid Diethylamide; Phenols; Phenylbutazone; Salicylates; Serotonin Antagonists

Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antigen-Antibody Reactions; Antirheumatic Agents; Detergents; Erythrocytes; Guinea Pigs; Hemolysis; Pharmacology; Phenylbutazone; Precipitin Tests; Research; Salicylates; Serum Albumin; Sheep; Sheep, Domestic; Sulfates

Topics: Aminosalicylic Acid; Aminosalicylic Acids; Anaphylaxis; Animals; Antibodies; Antibody Formation; Aspirin; Drug Hypersensitivity; Guinea Pigs; Hemagglutination; Hemagglutination Tests; Precipitin Tests; Rabbits; Research; Salicylates

Topics: Anaphylaxis; Formaldehyde; Guanidine; Guanidines; Guanine; Guinea Pigs; Hypersensitivity; Salicylates; Serum; Sodium Salicylate; Urea

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anaphylaxis; Animals; Calcium; Calcium Gluconate; Calcium, Dietary; Cortisone; Humans; Hypersensitivity; Lymph Nodes; Rabbits; Salicylates; Sodium Salicylate

Topics: Anaphylaxis; Aspirin; Histamine; Humans; Hypersensitivity; Immune System Diseases; Salicylates; Sodium Salicylate

Topics: Aminopyrine; Anaphylaxis; Humans; Hypersensitivity; Immune System Diseases; Salicylates

Topics: Anaphylaxis; Blood Vessels; Diphenhydramine; Heart; Humans; Hypersensitivity; Immune System Diseases; Myocardium; Salicylates

Topics: Anaphylaxis; Hypersensitivity; Immune System Diseases; Salicylates; Serum Sickness; Vaccines

Topics: Anaphylaxis; Aspirin; Hypersensitivity; Immune System Diseases; Salicylates

Topics: Anaphylaxis; Antipyrine; Hypersensitivity; Immune System Diseases; Salicylates; Sodium Salicylate

Topics: Anaphylaxis; Animals; Hypersensitivity; Immune System Diseases; Rabbits; Salicylates; Serum Sickness; Vaccines

Topics: Aminopyrine; Anaphylaxis; Antipyrine; Asthma; Humans; Hypersensitivity; Immune System Diseases; Salicylates