salicortin has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for salicortin and Neoplasms
Article | Year |
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Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy.
Willow (Salix spp.) is well known as a source of medicinal compounds, the most famous being salicin, the progenitor of aspirin. Here we describe the isolation, structure determination, and anti-cancer activity of a cyclodimeric salicinoid (miyabeacin) from S. miyabeana and S. dasyclados. We also show that the capability to produce such dimers is a heritable trait and how variation in structures of natural miyabeacin analogues is derived via cross-over Diels-Alder reactions from pools of ortho-quinol precursors. These transient ortho-quinols have a role in the, as yet uncharacterised, biosynthetic pathways around salicortin, the major salicinoid of many willow genotypes. Topics: Antineoplastic Agents, Phytogenic; Benzyl Alcohols; Biosynthetic Pathways; Cell Line, Tumor; Drug Screening Assays, Antitumor; Glucosides; Humans; Inhibitory Concentration 50; Neoplasms; Plant Bark; Salix | 2020 |