saikosaponin d has been researched along with Liver Neoplasms in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, J; Li, R; Lv, X; Wang, H; Wang, L; You, M | 1 |
| Lan, T; Mao, ZJ; Tong, YH; Wang, SW; Wang, W; Zeng, XX | 1 |
| Guo, J; Lin, S; Ma, Q; Min, W; Song, L; Wang, B; Yang, P | 1 |
| Liu, J; Liu, Q; Ren, S; Song, R; Xing, Y; Xu, J; Xue, Y; Yang, J; Zhang, Z | 1 |
| Chen, Y; Hou, X; Li, R; Lv, Y; Sun, R; Tian, Y; Xu, F; Xu, L; Zhang, Q; Zhang, Z | 1 |
| Bai, MH; Cheng, YA; Dai, ZJ; Lin, S; Ma, HB; Ma, XL; Min, WL; Song, LQ; Wang, BF; Wang, XJ; Wang, YL; Zan, Y | 1 |
| Bai, MH; Cheng, YA; Guan, HT; Kang, HF; Lin, S; Min, WL; Song, LQ; Wang, BF; Wang, XJ; Wang, ZW; Zan, Y | 1 |
| Bai, MH; Lin, S; Ma, HB; Min, WL; Song, LQ; Wang, BF; Wang, M; Wang, XJ; Yang, P | 1 |
| Chen, J; He, S; Hou, H; Lu, G; Lu, X; Wang, Z; Zhao, Z; Zhu, Z | 1 |
| Li, MY; Pu, R; Wang, LT; Yuan, JK; Zhang, GP; Zhu, BH | 1 |
| Cheng, Y; Dang, S; Jia, X; Li, M; Li, S; Li, Y; Zhang, X | 1 |
| Wen-Sheng, W | 1 |
| Chiang, LC; Hsu, YL; Kuo, PL; Lin, CC | 1 |
| Li, Q; Murakamio, T; Okita, K; Takahashi, M | 1 |
| Kimura, Y; Murakami, T; Okita, K; Qian, L; Takahashi, M | 1 |
| Hsu, HY; Wu, WS | 1 |
16 other study(ies) available for saikosaponin d and Liver Neoplasms
| Article | Year |
|---|---|
Saikosaponin b2 inhibits tumor angiogenesis in liver cancer via down‑regulation of VEGF/ERK/HIF‑1α signaling.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Movement; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms; Mice; Neovascularization, Pathologic; Signal Transduction; Vascular Endothelial Growth Factor A | 2023 |
Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression.
Topics: Activating Transcription Factor 3; Carcinoma, Hepatocellular; Endoplasmic Reticulum Stress; Ferroptosis; Glutathione; Humans; Iron; Liver Neoplasms; Transcription Factor 3 | 2023 |
Saikosaponin-d increases radiation-induced apoptosis of hepatoma cells by promoting autophagy via inhibiting mTOR phosphorylation.
Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemoradiotherapy; Humans; Liver Neoplasms; Oleanolic Acid; Phosphorylation; Radiation Tolerance; Saponins; TOR Serine-Threonine Kinases | 2021 |
Saikosaponins and the deglycosylated metabolites exert liver meridian guiding effect through PXR/CYP3A4 inhibition.
Topics: Bupleurum; Carcinoma, Hepatocellular; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Meridians; Microsomes, Liver; Oleanolic Acid; Pregnane X Receptor; Saponins; Time Factors | 2021 |
Untargeted Metabolomics Study of the In Vitro Anti-Hepatoma Effect of Saikosaponin d in Combination with NRP-1 Knockdown.
Topics: Carcinoma, Hepatocellular; Cell Survival; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Metabolomics; Molecular Docking Simulation; Molecular Targeted Therapy; Neuropilin-1; Oleanolic Acid; Saponins | 2019 |
Saikosaponin-d increases the radiosensitivity of smmc-7721 hepatocellular carcinoma cells by adjusting the g0/g1 and g2/m checkpoints of the cell cycle.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Liver Neoplasms; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; RNA, Messenger; Saponins; Tumor Suppressor Protein p53; X-Rays | 2013 |
Saikosaponin-D enhances radiosensitivity of hepatoma cells under hypoxic conditions by inhibiting hypoxia-inducible factor-1α.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Radiation Tolerance; Saponins; Tumor Stem Cell Assay; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2014 |
Effects of SSd combined with radiation on inhibiting SMMC-7721 hepatoma cell growth.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; In Vitro Techniques; Liver Neoplasms; Microscopy, Electron, Transmission; Oleanolic Acid; Radiation-Sensitizing Agents; Saponins; Tetrazolium Salts; Thiazoles | 2014 |
Saikosaponin‑d suppresses the expression of cyclooxygenase‑2 through the phospho‑signal transducer and activator of transcription 3/hypoxia‑inducible factor‑1α pathway in hepatocellular carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Cyclooxygenase 2; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Oleanolic Acid; Phosphorylation; Protein Processing, Post-Translational; Saponins; STAT3 Transcription Factor | 2014 |
[Effect of Saikosaponins-d on reversing malignant phenotype of HepG2 cells in vitro].
Topics: Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neoplasms; Oleanolic Acid; RNA, Messenger; Saponins | 2011 |
Effects of saikosaponin-d on syndecan-2, matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in rats with hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Matrix Metalloproteinases; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Syndecan-2; Tissue Inhibitor of Metalloproteinase-2 | 2012 |
ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.
Topics: Activating Transcription Factor 2; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Depression, Chemical; Electrophoresis, Capillary; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, p16; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Saponins; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Survival; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Membrane Glycoproteins; NF-kappa B; Oleanolic Acid; Proteins; Receptors, Tumor Necrosis Factor; Saponins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2004 |
Anti-growth effects with components of Sho-saiko-to (TJ-9) on cultured human hepatoma cells.
Topics: alpha-Fetoproteins; Antineoplastic Agents; Astringents; Carcinoma, Hepatocellular; Cell Cycle; Cell Death; Cell Division; DNA, Neoplasm; Drugs, Chinese Herbal; Flavanones; Flavonoids; Ginsenosides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Liver Neoplasms; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins; Tumor Cells, Cultured | 1993 |
Saikosaponin A-induced cell death of a human hepatoma cell line (HuH-7): the significance of the 'sub-G1 peak' in a DNA histogram.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; DNA, Neoplasm; Electrophoresis, Agar Gel; Flow Cytometry; Humans; Liver Neoplasms; Mitochondrial Swelling; Necrosis; Oleanolic Acid; Sapogenins; Saponins; Tumor Cells, Cultured | 1995 |
Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Liver Neoplasms; Oleanolic Acid; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sapogenins; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |