safrole has been researched along with Sensitivity and Specificity in 5 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The developed assay was applied to a pharmacokinetic study in humans." | 1.37 | Development and validation of a highly sensitive LC-MS/MS method for simultaneous quantitation of ethionamide and ethionamide sulfoxide in human plasma: application to a human pharmacokinetic study. ( Deshpande, AY; Gurav, S; Kulkarni, R; Mullangi, R; Mungantiwar, A; Pandey, S; Punde, R; Zambre, V, 2011) |
| " The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight." | 1.31 | Biological monitoring of environment exposure to safrole and the Taiwanese betel quid chewing. ( Chang, MJ; Hsieh, LL; Ko, CY; Lin, RF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barshteyn, N | 1 |
| Elfarra, AA | 1 |
| Deshpande, AY | 1 |
| Gurav, S | 1 |
| Punde, R | 1 |
| Zambre, V | 1 |
| Kulkarni, R | 1 |
| Pandey, S | 1 |
| Mungantiwar, A | 1 |
| Mullangi, R | 1 |
| Chang, MJ | 1 |
| Ko, CY | 1 |
| Lin, RF | 1 |
| Hsieh, LL | 1 |
| Picó, Y | 1 |
| Kozmutza, C | 1 |
| Randerath, K | 1 |
| Gupta, KP | 1 |
| van Golen, KL | 1 |
5 other studies available for safrole and Sensitivity and Specificity
| Article | Year |
|---|---|
Detection of multiple globin monoadducts and cross-links after in vitro exposure of rat erythrocytes to S-(1,2-dichlorovinyl)-L-cysteine sulfoxide and after in vivo treatment of rats with S-(1,2-dichlorovinyl)-L-cysteine sulfoxide.
Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Dimerization; Electrophoresis, Polyacrylami | 2008 |
Development and validation of a highly sensitive LC-MS/MS method for simultaneous quantitation of ethionamide and ethionamide sulfoxide in human plasma: application to a human pharmacokinetic study.
Topics: Antitubercular Agents; Chromatography, Liquid; Drug Stability; Ethionamide; Humans; Safrole; Sensiti | 2011 |
Biological monitoring of environment exposure to safrole and the Taiwanese betel quid chewing.
Topics: Administration, Oral; Adolescent; Adult; Animals; Body Weight; Chromatography, High Pressure Liquid; | 2002 |
Evaluation of pesticide residue in grape juices and the effect of natural antioxidants on their degradation rate.
Topics: Antioxidants; Beverages; Chromatography, Liquid; Food Contamination; Hydrogen-Ion Concentration; Pes | 2007 |
Altered fidelity of a nucleic acid modifying enzyme, T4 polynucleotide kinase, by safrole-induced DNA damage.
Topics: Animals; CD4-Positive T-Lymphocytes; Chromatography; DNA; DNA Damage; Female; Hydrolysis; Mice; Mice | 1993 |