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safrole and Pregnancy

safrole has been researched along with Pregnancy in 9 studies

Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" Chronic administration of low doses of DES to male Syrian hamsters led to an entirely different pattern of adducts in kidney DNA, the target organ of carcinogenesis."2.38Use of the 32P-postlabelling assay to study transplacental carcinogens and transplacental carcinogenesis. ( Gladek, A; Liehr, JG; Randerath, E; Randerath, K, 1989)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19907 (77.78)18.7374
1990's2 (22.22)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Phillips, DH1
Randerath, K4
Putman, KL1
Randerath, E2
Vesselinovitch, SD1
Rao, KV1
Mihailovich, N1
Liehr, JG1
Gladek, A1
Lu, LJ2
Disher, RM2
Reddy, MV1
Namkung, MJ1
Porubek, DJ1
Nelson, SD1
Juchau, MR2
Tuteja, N1
Gonzalez, FJ1
Nebert, DW1
Bark, DH1
Shewey, LM1
Greenaway, JC1

Reviews

2 reviews available for safrole and Pregnancy

ArticleYear
DNA adducts derived from safrole, estragole and related compounds, and from benzene and its metabolites.
    IARC scientific publications, 1994, Issue:125

    Topics: Allylbenzene Derivatives; Animals; Anisoles; Benzene; Carcinogens; DNA; DNA Adducts; Female; Flavori

1994
Use of the 32P-postlabelling assay to study transplacental carcinogens and transplacental carcinogenesis.
    IARC scientific publications, 1989, Issue:96

    Topics: 4-Nitroquinoline-1-oxide; Aminobiphenyl Compounds; Animals; Animals, Newborn; Benzo(a)pyrene; Carcin

1989

Other Studies

7 other studies available for safrole and Pregnancy

ArticleYear
Flavor constituents in cola drinks induce hepatic DNA adducts in adult and fetal mice.
    Biochemical and biophysical research communications, 1993, Apr-15, Volume: 192, Issue:1

    Topics: Allylbenzene Derivatives; Animals; Benzyl Compounds; Beverages; Dioxolanes; DNA Damage; Female; Fetu

1993
Transplacental and lactational carcinogenesis by safrole.
    Cancer research, 1979, Volume: 39, Issue:11

    Topics: Animals; Animals, Newborn; Dioxoles; Female; Kidney Neoplasms; Lactation; Liver Neoplasms, Experimen

1979
Differences in the covalent binding of benzo[a]pyrene, safrole, 1'-hydroxysafrole, and 4-aminobiphenyl to DNA of pregnant and non-pregnant mice.
    Cancer letters, 1986, Volume: 31, Issue:1

    Topics: Aminobiphenyl Compounds; Animals; Benzo(a)pyrene; Carcinogens; DNA; Female; Kidney; Liver; Lung; Mic

1986
32P-postlabeling assay in mice of transplacental DNA damage induced by the environmental carcinogens safrole, 4-aminobiphenyl, and benzo(a)pyrene.
    Cancer research, 1986, Volume: 46, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aminobiphenyl Compounds; Animals; Benzo(a)pyrene

1986
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
    Journal of steroid biochemistry, 1985, Volume: 22, Issue:4

    Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-4

1985
Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes.
    Developmental biology, 1985, Volume: 112, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromosome Mapping; Cytochrome P-450 CYP1A1; Cytochrome P-45

1985
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.
    Toxicology and applied pharmacology, 1985, Volume: 81, Issue:3 Pt 1

    Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Ch

1985