safrole has been researched along with Pregnancy in 9 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Excerpt | Relevance | Reference |
---|---|---|
" Chronic administration of low doses of DES to male Syrian hamsters led to an entirely different pattern of adducts in kidney DNA, the target organ of carcinogenesis." | 2.38 | Use of the 32P-postlabelling assay to study transplacental carcinogens and transplacental carcinogenesis. ( Gladek, A; Liehr, JG; Randerath, E; Randerath, K, 1989) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (77.78) | 18.7374 |
1990's | 2 (22.22) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Phillips, DH | 1 |
Randerath, K | 4 |
Putman, KL | 1 |
Randerath, E | 2 |
Vesselinovitch, SD | 1 |
Rao, KV | 1 |
Mihailovich, N | 1 |
Liehr, JG | 1 |
Gladek, A | 1 |
Lu, LJ | 2 |
Disher, RM | 2 |
Reddy, MV | 1 |
Namkung, MJ | 1 |
Porubek, DJ | 1 |
Nelson, SD | 1 |
Juchau, MR | 2 |
Tuteja, N | 1 |
Gonzalez, FJ | 1 |
Nebert, DW | 1 |
Bark, DH | 1 |
Shewey, LM | 1 |
Greenaway, JC | 1 |
2 reviews available for safrole and Pregnancy
Article | Year |
---|---|
DNA adducts derived from safrole, estragole and related compounds, and from benzene and its metabolites.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Benzene; Carcinogens; DNA; DNA Adducts; Female; Flavori | 1994 |
Use of the 32P-postlabelling assay to study transplacental carcinogens and transplacental carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Aminobiphenyl Compounds; Animals; Animals, Newborn; Benzo(a)pyrene; Carcin | 1989 |
7 other studies available for safrole and Pregnancy
Article | Year |
---|---|
Flavor constituents in cola drinks induce hepatic DNA adducts in adult and fetal mice.
Topics: Allylbenzene Derivatives; Animals; Benzyl Compounds; Beverages; Dioxolanes; DNA Damage; Female; Fetu | 1993 |
Transplacental and lactational carcinogenesis by safrole.
Topics: Animals; Animals, Newborn; Dioxoles; Female; Kidney Neoplasms; Lactation; Liver Neoplasms, Experimen | 1979 |
Differences in the covalent binding of benzo[a]pyrene, safrole, 1'-hydroxysafrole, and 4-aminobiphenyl to DNA of pregnant and non-pregnant mice.
Topics: Aminobiphenyl Compounds; Animals; Benzo(a)pyrene; Carcinogens; DNA; Female; Kidney; Liver; Lung; Mic | 1986 |
32P-postlabeling assay in mice of transplacental DNA damage induced by the environmental carcinogens safrole, 4-aminobiphenyl, and benzo(a)pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aminobiphenyl Compounds; Animals; Benzo(a)pyrene | 1986 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-4 | 1985 |
Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromosome Mapping; Cytochrome P-450 CYP1A1; Cytochrome P-45 | 1985 |
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Ch | 1985 |