safrole has been researched along with Precancerous Conditions in 6 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lipsky, MM | 3 |
| Hinton, DE | 3 |
| Klaunig, JE | 3 |
| Goldblatt, PJ | 2 |
| Trump, BF | 3 |
| Shieh, DH | 1 |
| Chiang, LC | 1 |
| Shieh, TY | 1 |
| Hanigan, MH | 1 |
| Winkler, ML | 1 |
| Drinkwater, NR | 1 |
| Boberg, EW | 1 |
| Liem, A | 1 |
| Miller, EC | 1 |
| Miller, JA | 1 |
6 other studies available for safrole and Precancerous Conditions
| Article | Year |
|---|---|
Gamma glutamyl transpeptidase in safrole-induced, presumptive premalignant mouse hepatocytes.
Topics: Animals; Carcinogens; gamma-Glutamyltransferase; Hepatectomy; Hepatocytes; Liver; Liver Neoplasms, E | 1980 |
Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis.
Topics: Adult; Aged; Areca; Arecoline; Cells, Cultured; Cheek; Dose-Response Relationship, Drug; Fibroblasts | 2003 |
Biology of hepatocellular neoplasia in the mouse. I. Histogenesis of safrole-induced hepatocellular carcinoma.
Topics: Adenoma; Animals; Body Weight; Dioxoles; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inb | 1981 |
Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms; | 1993 |
Iron negative foci and nodules in safrole-exposed mouse liver made siderotic by iron-dextran injection.
Topics: Animals; Dioxoles; Iron; Iron-Dextran Complex; Kupffer Cells; Liver; Liver Neoplasms; Male; Mice; Mi | 1979 |
Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.
Topics: Animals; Chick Embryo; Chlorophenols; Cocarcinogenesis; Diethylnitrosamine; Dioxoles; Female; gamma- | 1987 |