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safrole and Pleurisy

safrole has been researched along with Pleurisy in 1 studies

Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.

Pleurisy: INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.

Research Excerpts

ExcerptRelevanceReference
" The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay."3.70Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole. ( Barreiro, EJ; Fraga, CA; Lages, AS; Miranda, AL; Silva, KC, 1998)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lages, AS1
Silva, KC1
Miranda, AL1
Fraga, CA1
Barreiro, EJ1

Other Studies

1 other study available for safrole and Pleurisy

ArticleYear
Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole.
    Bioorganic & medicinal chemistry letters, 1998, Jan-20, Volume: 8, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal;

1998