safrole has been researched along with Oral Submucous Fibrosis in 3 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Oral Submucous Fibrosis: Irreversible FIBROSIS of the submucosal tissue of the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Safrole was cytotoxic to BMFs in a dose-dependent manner (p<0." | 5.34 | Elevated expression of NF-kappaB in oral submucous fibrosis--evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts. ( Chang, YC; Ni, WF; Tsai, CH; Yang, SF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shieh, DH | 2 |
| Chiang, LC | 2 |
| Shieh, TY | 2 |
| Lee, CH | 1 |
| Yang, YH | 1 |
| Ni, WF | 1 |
| Tsai, CH | 1 |
| Yang, SF | 1 |
| Chang, YC | 1 |
3 other studies available for safrole and Oral Submucous Fibrosis
| Article | Year |
|---|---|
Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis.
Topics: Adult; Aged; Areca; Arecoline; Cells, Cultured; Cheek; Dose-Response Relationship, Drug; Fibroblasts | 2003 |
Effects of arecoline, safrole, and nicotine on collagen phagocytosis by human buccal mucosal fibroblasts as a possible mechanism for oral submucous fibrosis in Taiwan.
Topics: Adult; Arecoline; Cell Survival; Cells, Cultured; Cholinergic Agonists; Collagen; Dose-Response Rela | 2004 |
Elevated expression of NF-kappaB in oral submucous fibrosis--evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts.
Topics: Blotting, Western; Cells, Cultured; Cheek; Fibroblasts; Gene Expression; Humans; Immunohistochemistr | 2007 |