Page last updated: 2024-11-04

safrole and Neoplasms

safrole has been researched along with Neoplasms in 8 studies

Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S2
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Ge, D1
Jing, Q1
Zhao, W1
Yue, H1
Su, L1
Zhao, J1
Bode, AM1
Dong, Z1
HAGAN, EC1
JENNER, PM1
JONES, WI1
FITZHUGH, OG1
LONG, EL1
BROUWER, JG1
WEBB, WK1
Fairweather, FA1
Swann, CA1
Miller, EC2
Miller, JA2

Reviews

4 reviews available for safrole and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Toxic phytochemicals and their potential risks for human cancer.
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:1

    Topics: Amygdalin; Aristolochic Acids; Capsaicin; Cell Line, Tumor; Cycasin; Diet; Drug Screening Assays, An

2015
Food additives and cancer.
    The Proceedings of the Nutrition Society, 1981, Volume: 40, Issue:1

    Topics: Animals; Chemical Phenomena; Chemistry; Female; Food Additives; Food Coloring Agents; Furylfuramide;

1981
Carcinogens occurring naturally in foods.
    Federation proceedings, 1976, May-01, Volume: 35, Issue:6

    Topics: Aflatoxins; Animals; Carcinogens, Environmental; Cycasin; Ethionine; Food; Griseofulvin; Humans; Neo

1976

Other Studies

4 other studies available for safrole and Neoplasms

ArticleYear
Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Activating Transcription Factor 4; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques;

2014
Safrole.
    Report on carcinogens : carcinogen profiles, 2011, Volume: 12

    Topics: Animals; Carcinogens; Flavoring Agents; Humans; Neoplasms; Safrole

2011
TOXIC PROPERTIES OF COMPOUNDS RELATED TO SAFROLE.
    Toxicology and applied pharmacology, 1965, Volume: 7

    Topics: Animals; Carcinogens; Dogs; Esophageal Neoplasms; Guinea Pigs; Liver Neoplasms; Mice; Neoplasms; Neo

1965
Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules.
    Cancer, 1981, May-15, Volume: 47, Issue:10

    Topics: 2-Acetylaminofluorene; Aflatoxins; Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; C

1981