safrole has been researched along with Mouth Neoplasms in 6 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Mouth Neoplasms: Tumors or cancer of the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Safrole is a known rodent hepatocarcinogen, yet its carcinogenicity in human beings is largely undetermined." | 1.30 | Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history. ( Chang, KW; Chen, CL; Chi, CW; Liu, TY, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsou, HH | 1 |
| Ko, HT | 1 |
| Chen, CT | 1 |
| Wang, TW | 1 |
| Lee, CH | 1 |
| Liu, TY | 4 |
| Wang, HT | 1 |
| Chung, YT | 1 |
| Hsieh, LL | 1 |
| Chen, IH | 1 |
| Liao, CT | 1 |
| Liou, SH | 1 |
| Chi, CW | 2 |
| Ueng, YF | 1 |
| Yu, FS | 1 |
| Yang, JS | 1 |
| Yu, CS | 1 |
| Lu, CC | 1 |
| Chiang, JH | 1 |
| Lin, CW | 1 |
| Chung, JG | 1 |
| Shieh, DH | 1 |
| Chiang, LC | 1 |
| Shieh, TY | 1 |
| Chen, CL | 2 |
| Chang, KW | 2 |
| Liu, CJ | 1 |
| Chu, CH | 1 |
6 other studies available for safrole and Mouth Neoplasms
| Article | Year |
|---|---|
Betel quid containing safrole enhances metabolic activation of tobacco specific 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Activation, Metabolic; Animals; Carcinoma, Squamous Cell; Cricetinae; Cytochrome P-450 CYP2A6; Femal | 2019 |
Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Animals; Arylsulfotransferase; Carcinoma, Squamous | 2009 |
Safrole induces apoptosis in human oral cancer HSC-3 cells.
Topics: Analysis of Variance; Animals; Apoptosis; Calcium; Carcinoma, Squamous Cell; Caspase 3; Caspase 8; C | 2011 |
Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis.
Topics: Adult; Aged; Areca; Arecoline; Cells, Cultured; Cheek; Dose-Response Relationship, Drug; Fibroblasts | 2003 |
Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history.
Topics: Areca; Autoradiography; Carcinoma, Squamous Cell; DNA Adducts; Humans; Mouth Neoplasms; Plants, Medi | 1999 |
Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report.
Topics: Areca; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; DNA Adducts; Humans; Liver Function Test | 2000 |