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safrole and Liver Neoplasms

safrole has been researched along with Liver Neoplasms in 16 studies

Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.

Liver Neoplasms: Tumors or cancer of the LIVER.

Research Excerpts

ExcerptRelevanceReference
" Likewise, the chronic administration of a nontoxic level of pentachlorophenol in the diet of adult female CD-1 mice strongly inhibited hepatic tumor induction by long-term dietary administration of either safrole or 1'-hydroxysafrole."1.27Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver. ( Boberg, EW; Liem, A; Miller, EC; Miller, JA; Poland, A, 1983)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199013 (81.25)18.7374
1990's1 (6.25)18.2507
2000's1 (6.25)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Song, X1
Yin, Z1
Ye, K1
Wei, Q1
Jia, R1
Zhou, L1
Du, Y1
Xu, J1
Liang, X1
He, C1
Shu, G1
Yin, L1
Lv, C1
HAGAN, EC1
JENNER, PM1
JONES, WI1
FITZHUGH, OG1
LONG, EL1
BROUWER, JG1
WEBB, WK1
Newberne, PM1
Miller, JA6
Miller, EC6
Boberg, EW2
Poland, A1
Liem, A3
Swanson, AB1
Phillips, DH1
Fletcher, TL1
Hirono, I1
Hanigan, MH1
Winkler, ML1
Drinkwater, NR1
Liu, CJ1
Chen, CL1
Chang, KW1
Chu, CH1
Liu, TY1
Doumas, J1
Maume, BF1
Wislocki, PG1
McCoy, EC1
Rosenkranz, HS1
Reuber, MD1
Lipsky, MM1
Hinton, DE1
Goldblatt, PJ1
Klaunig, JE1
Trump, BF1
Delclos, KB1
Lai, CC1
Fennell, TR2
Wiseman, RW2

Reviews

5 reviews available for safrole and Liver Neoplasms

ArticleYear
Chemical carcinogenesis: mycotoxins and other chemicals to which humans are exposed.
    Seminars in liver disease, 1984, Volume: 4, Issue:2

    Topics: Aflatoxins; Alcoholism; Animals; Carcinoma, Hepatocellular; Diet; Glycosides; Hepatitis B; Humans; H

1984
The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole.
    British journal of cancer, 1983, Volume: 48, Issue:1

    Topics: Adenine; Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Carcinogens, Environmental;

1983
Natural carcinogenic products of plant origin.
    Critical reviews in toxicology, 1981, Volume: 8, Issue:3

    Topics: Aflatoxins; Alkaloids; Animals; Areca; Basidiomycota; Carcinogens; Carcinogens, Environmental; Crice

1981
Safrole, isosafrole and dihydrosafrole.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 1976, Volume: 10

    Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Cricetin

1976
Sulfuric acid esters as ultimate electrophilic and carcinogenic metabolites of some alkenylbenzenes and aromatic amines in mouse liver.
    Carcinogenesis; a comprehensive survey, 1985, Volume: 10

    Topics: 2-Acetylaminofluorene; Animals; Azo Compounds; Biotransformation; Carcinogens; Chemical Phenomena; C

1985

Other Studies

11 other studies available for safrole and Liver Neoplasms

ArticleYear
Anti-hepatoma effect of safrole from Cinnamomum longepaniculatum leaf essential oil in vitro.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prol

2014
TOXIC PROPERTIES OF COMPOUNDS RELATED TO SAFROLE.
    Toxicology and applied pharmacology, 1965, Volume: 7

    Topics: Animals; Carcinogens; Dogs; Esophageal Neoplasms; Guinea Pigs; Liver Neoplasms; Mice; Neoplasms; Neo

1965
Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.
    Cancer research, 1983, Volume: 43, Issue:11

    Topics: Animals; Carcinogens; Chlorophenols; Cytosol; Dioxoles; Female; Kinetics; Liver; Liver Neoplasms; Ma

1983
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Administration, Oral; Allylbenzene Derivatives; Animals; Anisoles; Dioxoles; Female; Injections, Int

1983
Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice.
    Carcinogenesis, 1993, Volume: 14, Issue:5

    Topics: Animals; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms;

1993
Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2000, Feb-08, Volume: 162, Issue:3

    Topics: Areca; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; DNA Adducts; Humans; Liver Function Test

2000
[Metabolic activation by adrenal tissue in rats of a liver carcinogen: safrole].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1977, Volume: 171, Issue:1

    Topics: Adrenal Glands; Animals; Dioxoles; Humans; In Vitro Techniques; Liver; Liver Neoplasms; Male; Mice;

1977
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
    Cancer research, 1977, Volume: 37, Issue:6

    Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Ne

1977
Neoplasms of the forestomach in mice ingesting dihydrosafrole.
    Digestion, 1979, Volume: 19, Issue:1

    Topics: Animals; Dioxoles; Hyperplasia; Liver Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental

1979
Iron negative foci and nodules in safrole-exposed mouse liver made siderotic by iron-dextran injection.
    Pathology, research and practice, 1979, Volume: 164, Issue:2

    Topics: Animals; Dioxoles; Iron; Iron-Dextran Complex; Kupffer Cells; Liver; Liver Neoplasms; Male; Mice; Mi

1979
Further characterization of the DNA adducts formed by electrophilic esters of the hepatocarcinogens 1'-hydroxysafrole and 1'-hydroxyestragole in vitro and in mouse liver in vivo, including new adducts at C-8 and N-7 of guanine residues.
    Cancer research, 1985, Volume: 45, Issue:7

    Topics: Animals; Anisoles; Carcinogens; Chromatography, High Pressure Liquid; Dioxoles; DNA; Guanine; In Vit

1985