safrole has been researched along with Liver Dysfunction in 3 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previously it was shown that methylenedioxybenzenes (MDBs), particularly isosafrole, were highly effective at preventing CCl4-induced liver necrosis in vivo (Z." | 3.69 | The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants. ( Khan, S; O'Brien, PJ; Zhao, ZS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HOMBURGER, F | 1 |
| KELLEY, T | 1 |
| BAKER, TR | 1 |
| RUSSFIELD, AB | 1 |
| Zhao, ZS | 1 |
| Khan, S | 1 |
| O'Brien, PJ | 1 |
| Crampton, RF | 1 |
| Gray, TJ | 1 |
| Grasso, P | 1 |
| Parke, DV | 1 |
3 other studies available for safrole and Liver Dysfunction
| Article | Year |
|---|---|
Sex effect on hepatic pathology from deficient diet and safrole in rats.
Topics: Animals; Benzene Derivatives; Diet; Flavoring Agents; Liver Diseases; Rats; Safrole | 1962 |
The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1997 |
Long-term studies on chemically induced liver enlargement in the rat. II. Transient induction of microsomal enzymes leading to liver damage and nodular hyperplasia produced by safrole and Ponceau MX.
Topics: Animals; Azo Compounds; Chemical and Drug Induced Liver Injury; Diet; Dioxoles; Enzyme Induction; Fe | 1977 |