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safrole and Liver Diseases

safrole has been researched along with Liver Diseases in 3 studies

Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.

Liver Diseases: Pathological processes of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Previously it was shown that methylenedioxybenzenes (MDBs), particularly isosafrole, were highly effective at preventing CCl4-induced liver necrosis in vivo (Z."3.69The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants. ( Khan, S; O'Brien, PJ; Zhao, ZS, 1997)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
HOMBURGER, F1
KELLEY, T1
BAKER, TR1
RUSSFIELD, AB1
Zhao, ZS1
Khan, S1
O'Brien, PJ1
Crampton, RF1
Gray, TJ1
Grasso, P1
Parke, DV1

Other Studies

3 other studies available for safrole and Liver Diseases

ArticleYear
Sex effect on hepatic pathology from deficient diet and safrole in rats.
    Archives of pathology, 1962, Volume: 73

    Topics: Animals; Benzene Derivatives; Diet; Flavoring Agents; Liver Diseases; Rats; Safrole

1962
The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants.
    Chemico-biological interactions, 1997, Dec-12, Volume: 108, Issue:1-2

    Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme

1997
Long-term studies on chemically induced liver enlargement in the rat. II. Transient induction of microsomal enzymes leading to liver damage and nodular hyperplasia produced by safrole and Ponceau MX.
    Toxicology, 1977, Volume: 7, Issue:3

    Topics: Animals; Azo Compounds; Chemical and Drug Induced Liver Injury; Diet; Dioxoles; Enzyme Induction; Fe

1977