safrole has been researched along with Hepatocellular Carcinoma in 6 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known." | 5.35 | Safrole-DNA adduct in hepatocellular carcinoma associated with betel quid chewing. ( Chan, SA; Chen, CL; Chi, CW; Chung, YT; Liu, TY; Wu, CC, 2008) |
| "Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known." | 1.35 | Safrole-DNA adduct in hepatocellular carcinoma associated with betel quid chewing. ( Chan, SA; Chen, CL; Chi, CW; Chung, YT; Liu, TY; Wu, CC, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, X | 1 |
| Yin, Z | 1 |
| Ye, K | 1 |
| Wei, Q | 1 |
| Jia, R | 1 |
| Zhou, L | 1 |
| Du, Y | 1 |
| Xu, J | 1 |
| Liang, X | 1 |
| He, C | 1 |
| Shu, G | 1 |
| Yin, L | 1 |
| Lv, C | 1 |
| Chung, YT | 1 |
| Chen, CL | 2 |
| Wu, CC | 1 |
| Chan, SA | 1 |
| Chi, CW | 1 |
| Liu, TY | 2 |
| Newberne, PM | 1 |
| Liu, CJ | 1 |
| Chang, KW | 1 |
| Chu, CH | 1 |
| Wislocki, PG | 1 |
| Miller, EC | 1 |
| Miller, JA | 1 |
| McCoy, EC | 1 |
| Rosenkranz, HS | 1 |
2 reviews available for safrole and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Chemical carcinogenesis: mycotoxins and other chemicals to which humans are exposed.
Topics: Aflatoxins; Alcoholism; Animals; Carcinoma, Hepatocellular; Diet; Glycosides; Hepatitis B; Humans; H | 1984 |
Safrole, isosafrole and dihydrosafrole.
Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Cricetin | 1976 |
4 other studies available for safrole and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Anti-hepatoma effect of safrole from Cinnamomum longepaniculatum leaf essential oil in vitro.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prol | 2014 |
Safrole-DNA adduct in hepatocellular carcinoma associated with betel quid chewing.
Topics: Alcohol Drinking; Animals; Areca; Carcinoma, Hepatocellular; Chromatography, Liquid; DNA Adducts; Fe | 2008 |
Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report.
Topics: Areca; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; DNA Adducts; Humans; Liver Function Test | 2000 |
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Ne | 1977 |