safrole has been researched along with Experimental Neoplasms in 9 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, TI | 1 |
| Yang, YC | 1 |
| Chiang, WH | 1 |
| Hung, CK | 1 |
| Tsai, YC | 1 |
| Chiang, CS | 1 |
| Lo, CL | 1 |
| Chiu, HC | 1 |
| HAGAN, EC | 1 |
| JENNER, PM | 1 |
| JONES, WI | 1 |
| FITZHUGH, OG | 1 |
| LONG, EL | 1 |
| BROUWER, JG | 1 |
| WEBB, WK | 1 |
| Fairweather, FA | 1 |
| Swann, CA | 1 |
| Hirono, I | 1 |
| Wislocki, PG | 1 |
| Miller, EC | 1 |
| Miller, JA | 1 |
| McCoy, EC | 1 |
| Rosenkranz, HS | 1 |
| Reuber, MD | 1 |
| Vesselinovitch, SD | 1 |
| Rao, KV | 1 |
| Mihailovich, N | 1 |
| Farnsworth, NR | 1 |
| Bingel, AS | 1 |
| Fong, HH | 1 |
| Saleh, AA | 1 |
| Christenson, GM | 1 |
| Saufferer, SM | 1 |
| Segelman, AB | 1 |
| Segelman, FP | 1 |
| Karliner, J | 1 |
| Sofia, RD | 1 |
3 reviews available for safrole and Experimental Neoplasms
| Article | Year |
|---|---|
Food additives and cancer.
Topics: Animals; Chemical Phenomena; Chemistry; Female; Food Additives; Food Coloring Agents; Furylfuramide; | 1981 |
Natural carcinogenic products of plant origin.
Topics: Aflatoxins; Alkaloids; Animals; Areca; Basidiomycota; Carcinogens; Carcinogens, Environmental; Crice | 1981 |
Oncogenic and tumor-promoting Spermatophytes and Pteridophytes and their active principles.
Topics: Animal Feed; Animals; Areca; Caffeine; Carcinogens; Chemical Phenomena; Chemistry; Croton Oil; Femal | 1976 |
6 other studies available for safrole and Experimental Neoplasms
| Article | Year |
|---|---|
Radiotherapy-Controllable Chemotherapy from Reactive Oxygen Species-Responsive Polymeric Nanoparticles for Effective Local Dual Modality Treatment of Malignant Tumors.
Topics: Adipates; Animals; Antineoplastic Agents; Cell Line, Tumor; Chemoradiotherapy; Drug Liberation; Irin | 2018 |
TOXIC PROPERTIES OF COMPOUNDS RELATED TO SAFROLE.
Topics: Animals; Carcinogens; Dogs; Esophageal Neoplasms; Guinea Pigs; Liver Neoplasms; Mice; Neoplasms; Neo | 1965 |
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Ne | 1977 |
Neoplasms of the forestomach in mice ingesting dihydrosafrole.
Topics: Animals; Dioxoles; Hyperplasia; Liver Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 1979 |
Transplacental and lactational carcinogenesis by safrole.
Topics: Animals; Animals, Newborn; Dioxoles; Female; Kidney Neoplasms; Lactation; Liver Neoplasms, Experimen | 1979 |
Sassafras and herb tea. Potential health hazards.
Topics: Animals; Carcinogens; Dioxoles; Disease Models, Animal; Humans; Magnoliopsida; Male; Neoplasms, Expe | 1976 |