safrole has been researched along with Experimental Hepatoma in 13 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A systematic, ultrastructural analysis wsa performed on safrole-induced hepatocellular adenomas and hepatocellular carcinoma(s) (HPC) in BALB/c mice." | 7.66 | Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas. ( Hinton, DE; Klaunig, JE; Lipsky, MM; Trump, BF, 1981) |
| "Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known." | 5.35 | Safrole-DNA adduct in hepatocellular carcinoma associated with betel quid chewing. ( Chan, SA; Chen, CL; Chi, CW; Chung, YT; Liu, TY; Wu, CC, 2008) |
| "A systematic, ultrastructural analysis wsa performed on safrole-induced hepatocellular adenomas and hepatocellular carcinoma(s) (HPC) in BALB/c mice." | 3.66 | Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas. ( Hinton, DE; Klaunig, JE; Lipsky, MM; Trump, BF, 1981) |
| "Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known." | 1.35 | Safrole-DNA adduct in hepatocellular carcinoma associated with betel quid chewing. ( Chan, SA; Chen, CL; Chi, CW; Chung, YT; Liu, TY; Wu, CC, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, YT | 1 |
| Chen, CL | 1 |
| Wu, CC | 1 |
| Chan, SA | 1 |
| Chi, CW | 1 |
| Liu, TY | 1 |
| Lipsky, MM | 4 |
| Hinton, DE | 4 |
| Klaunig, JE | 4 |
| Goldblatt, PJ | 2 |
| Trump, BF | 4 |
| Newberne, PM | 1 |
| Miller, JA | 6 |
| Miller, EC | 6 |
| Vesselinovitch, SD | 1 |
| Rao, KV | 1 |
| Mihailovich, N | 1 |
| Boberg, EW | 2 |
| Liem, A | 3 |
| Wiseman, RW | 3 |
| Drinkwater, NR | 1 |
| Blomquist, JC | 1 |
| Delclos, KB | 1 |
| Lai, CC | 1 |
| Fennell, TR | 1 |
3 reviews available for safrole and Experimental Hepatoma
| Article | Year |
|---|---|
Chemical carcinogenesis: mycotoxins and other chemicals to which humans are exposed.
Topics: Aflatoxins; Alcoholism; Animals; Carcinoma, Hepatocellular; Diet; Glycosides; Hepatitis B; Humans; H | 1984 |
The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole.
Topics: Adenine; Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Carcinogens, Environmental; | 1983 |
Sulfuric acid esters as ultimate electrophilic and carcinogenic metabolites of some alkenylbenzenes and aromatic amines in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Azo Compounds; Biotransformation; Carcinogens; Chemical Phenomena; C | 1985 |
10 other studies available for safrole and Experimental Hepatoma
| Article | Year |
|---|---|
Safrole-DNA adduct in hepatocellular carcinoma associated with betel quid chewing.
Topics: Alcohol Drinking; Animals; Areca; Carcinoma, Hepatocellular; Chromatography, Liquid; DNA Adducts; Fe | 2008 |
Gamma glutamyl transpeptidase in safrole-induced, presumptive premalignant mouse hepatocytes.
Topics: Animals; Carcinogens; gamma-Glutamyltransferase; Hepatectomy; Hepatocytes; Liver; Liver Neoplasms, E | 1980 |
Biology of hepatocellular neoplasia in the mouse. I. Histogenesis of safrole-induced hepatocellular carcinoma.
Topics: Adenoma; Animals; Body Weight; Dioxoles; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inb | 1981 |
Biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis of BALB/c mouse liver during safrole-induced carcinogenesis.
Topics: Adenoma; Animals; Dioxoles; Histocytochemistry; Iron; Kupffer Cells; Liver; Liver Neoplasms, Experim | 1981 |
Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas.
Topics: Adenoma; Animals; Cell Nucleus; Cytoplasm; Dioxoles; Endoplasmic Reticulum; Liver Neoplasms, Experim | 1981 |
Transplacental and lactational carcinogenesis by safrole.
Topics: Animals; Animals, Newborn; Dioxoles; Female; Kidney Neoplasms; Lactation; Liver Neoplasms, Experimen | 1979 |
Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.
Topics: Animals; Chick Embryo; Chlorophenols; Cocarcinogenesis; Diethylnitrosamine; Dioxoles; Female; gamma- | 1987 |
Apurinic/apyrimidinic site induction in supercoiled DNA and mutagenesis in Salmonella typhimurium TA100 by 1'-acetoxysafrole and related electrophilic alkenylbenzene derivatives.
Topics: Alkylation; Animals; Benzene; Dioxoles; DNA, Superhelical; Liver Neoplasms, Experimental; Male; Mice | 1986 |
Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice.
Topics: Age Factors; Allylbenzene Derivatives; Animals; Animals, Suckling; Anisoles; Chromatography, High Pr | 1987 |
Electrophilic sulfuric acid ester metabolites as ultimate carcinogens.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; DNA; Liver; Liver Neoplasms, Experimental; Male | 1986 |