safrole has been researched along with Disease Models, Animal in 4 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay." | 3.70 | Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole. ( Barreiro, EJ; Fraga, CA; Lages, AS; Miranda, AL; Silva, KC, 1998) |
| "Here, we report that seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase (LDH), a component of the astrocyte-neuron lactate shuttle." | 1.42 | Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. ( Inoue, T; Katsu, T; Lee, S; Otsuki, T; Sada, N, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sada, N | 1 |
| Lee, S | 1 |
| Katsu, T | 1 |
| Otsuki, T | 1 |
| Inoue, T | 2 |
| Jin, M | 1 |
| Kijima, A | 1 |
| Suzuki, Y | 1 |
| Hibi, D | 1 |
| Ishii, Y | 1 |
| Nohmi, T | 1 |
| Nishikawa, A | 1 |
| Ogawa, K | 1 |
| Umemura, T | 1 |
| Lages, AS | 1 |
| Silva, KC | 1 |
| Miranda, AL | 1 |
| Fraga, CA | 1 |
| Barreiro, EJ | 1 |
| Segelman, AB | 1 |
| Segelman, FP | 1 |
| Karliner, J | 1 |
| Sofia, RD | 1 |
4 other studies available for safrole and Disease Models, Animal
| Article | Year |
|---|---|
Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy.
Topics: Animals; Anticonvulsants; Dioxolanes; Disease Models, Animal; Enzyme Inhibitors; L-Lactate Dehydroge | 2015 |
Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; De | 2011 |
Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; | 1998 |
Sassafras and herb tea. Potential health hazards.
Topics: Animals; Carcinogens; Dioxoles; Disease Models, Animal; Humans; Magnoliopsida; Male; Neoplasms, Expe | 1976 |