safrole has been researched along with Cancer of Lung in 6 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shahadin, MS | 1 |
| Ab Mutalib, NS | 1 |
| Latif, MT | 1 |
| Greene, CM | 1 |
| Hassan, T | 1 |
| Du, A | 3 |
| Zhang, S | 3 |
| Miao, J | 3 |
| Zhao, B | 3 |
| Du, AY | 1 |
| Zhao, BX | 1 |
| Yin, DL | 1 |
| Zhang, SL | 1 |
| Miao, JY | 1 |
| Yin, D | 2 |
2 reviews available for safrole and Cancer of Lung
| Article | Year |
|---|---|
Challenges and future direction of molecular research in air pollution-related lung cancers.
Topics: Air Pollutants; Air Pollution; Carcinogenesis; DNA Damage; Environmental Exposure; Epigenomics; Gene | 2018 |
Safrole, isosafrole and dihydrosafrole.
Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Cricetin | 1976 |
4 other studies available for safrole and Cancer of Lung
| Article | Year |
|---|---|
Safrole oxide induces apoptosis in A549 human lung cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Fluorescen | 2004 |
Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lung cancer cells.
Topics: Apoptosis; Caspase 3; Caspase 8; Caspases; Chromatin; Endothelial Cells; G1 Phase; Humans; Lung Neop | 2005 |
Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; Cell Line, T | 2006 |
Safrole oxide induces apoptosis by up-regulating Fas and FasL instead of integrin beta4 in A549 human lung cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Humans; Integrin beta4; Lung Neoplasm | 2006 |