safrole has been researched along with Cancer of Liver in 16 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Likewise, the chronic administration of a nontoxic level of pentachlorophenol in the diet of adult female CD-1 mice strongly inhibited hepatic tumor induction by long-term dietary administration of either safrole or 1'-hydroxysafrole." | 1.27 | Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver. ( Boberg, EW; Liem, A; Miller, EC; Miller, JA; Poland, A, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, X | 1 |
| Yin, Z | 1 |
| Ye, K | 1 |
| Wei, Q | 1 |
| Jia, R | 1 |
| Zhou, L | 1 |
| Du, Y | 1 |
| Xu, J | 1 |
| Liang, X | 1 |
| He, C | 1 |
| Shu, G | 1 |
| Yin, L | 1 |
| Lv, C | 1 |
| HAGAN, EC | 1 |
| JENNER, PM | 1 |
| JONES, WI | 1 |
| FITZHUGH, OG | 1 |
| LONG, EL | 1 |
| BROUWER, JG | 1 |
| WEBB, WK | 1 |
| Newberne, PM | 1 |
| Miller, JA | 6 |
| Miller, EC | 6 |
| Boberg, EW | 2 |
| Poland, A | 1 |
| Liem, A | 3 |
| Swanson, AB | 1 |
| Phillips, DH | 1 |
| Fletcher, TL | 1 |
| Hirono, I | 1 |
| Hanigan, MH | 1 |
| Winkler, ML | 1 |
| Drinkwater, NR | 1 |
| Liu, CJ | 1 |
| Chen, CL | 1 |
| Chang, KW | 1 |
| Chu, CH | 1 |
| Liu, TY | 1 |
| Doumas, J | 1 |
| Maume, BF | 1 |
| Wislocki, PG | 1 |
| McCoy, EC | 1 |
| Rosenkranz, HS | 1 |
| Reuber, MD | 1 |
| Lipsky, MM | 1 |
| Hinton, DE | 1 |
| Goldblatt, PJ | 1 |
| Klaunig, JE | 1 |
| Trump, BF | 1 |
| Delclos, KB | 1 |
| Lai, CC | 1 |
| Fennell, TR | 2 |
| Wiseman, RW | 2 |
5 reviews available for safrole and Cancer of Liver
| Article | Year |
|---|---|
Chemical carcinogenesis: mycotoxins and other chemicals to which humans are exposed.
Topics: Aflatoxins; Alcoholism; Animals; Carcinoma, Hepatocellular; Diet; Glycosides; Hepatitis B; Humans; H | 1984 |
The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole.
Topics: Adenine; Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Carcinogens, Environmental; | 1983 |
Natural carcinogenic products of plant origin.
Topics: Aflatoxins; Alkaloids; Animals; Areca; Basidiomycota; Carcinogens; Carcinogens, Environmental; Crice | 1981 |
Safrole, isosafrole and dihydrosafrole.
Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Cricetin | 1976 |
Sulfuric acid esters as ultimate electrophilic and carcinogenic metabolites of some alkenylbenzenes and aromatic amines in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Azo Compounds; Biotransformation; Carcinogens; Chemical Phenomena; C | 1985 |
11 other studies available for safrole and Cancer of Liver
| Article | Year |
|---|---|
Anti-hepatoma effect of safrole from Cinnamomum longepaniculatum leaf essential oil in vitro.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prol | 2014 |
TOXIC PROPERTIES OF COMPOUNDS RELATED TO SAFROLE.
Topics: Animals; Carcinogens; Dogs; Esophageal Neoplasms; Guinea Pigs; Liver Neoplasms; Mice; Neoplasms; Neo | 1965 |
Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.
Topics: Animals; Carcinogens; Chlorophenols; Cytosol; Dioxoles; Female; Kinetics; Liver; Liver Neoplasms; Ma | 1983 |
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
Topics: Administration, Oral; Allylbenzene Derivatives; Animals; Anisoles; Dioxoles; Female; Injections, Int | 1983 |
Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms; | 1993 |
Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report.
Topics: Areca; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; DNA Adducts; Humans; Liver Function Test | 2000 |
[Metabolic activation by adrenal tissue in rats of a liver carcinogen: safrole].
Topics: Adrenal Glands; Animals; Dioxoles; Humans; In Vitro Techniques; Liver; Liver Neoplasms; Male; Mice; | 1977 |
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Ne | 1977 |
Neoplasms of the forestomach in mice ingesting dihydrosafrole.
Topics: Animals; Dioxoles; Hyperplasia; Liver Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 1979 |
Iron negative foci and nodules in safrole-exposed mouse liver made siderotic by iron-dextran injection.
Topics: Animals; Dioxoles; Iron; Iron-Dextran Complex; Kupffer Cells; Liver; Liver Neoplasms; Male; Mice; Mi | 1979 |
Further characterization of the DNA adducts formed by electrophilic esters of the hepatocarcinogens 1'-hydroxysafrole and 1'-hydroxyestragole in vitro and in mouse liver in vivo, including new adducts at C-8 and N-7 of guanine residues.
Topics: Animals; Anisoles; Carcinogens; Chromatography, High Pressure Liquid; Dioxoles; DNA; Guanine; In Vit | 1985 |