safrole has been researched along with Cancer of Esophagus in 2 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In total, we evaluated 47 patients with esophageal cancer (16 areca chewers and 31 non-chewers) who underwent esophagectomy at the National Taiwan University Hospital between 1996 and 2002." | 1.33 | Safrole-DNA adducts in tissues from esophageal cancer patients: clues to areca-related esophageal carcinogenesis. ( Chen, JS; Hsu, HH; Huang, PM; Lee, CJ; Lee, JM; Lee, YC; Leh, J; Liu, TY; Tang, HC; Wu, DC; Wu, MT, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HAGAN, EC | 1 |
| JENNER, PM | 1 |
| JONES, WI | 1 |
| FITZHUGH, OG | 1 |
| LONG, EL | 1 |
| BROUWER, JG | 1 |
| WEBB, WK | 1 |
| Lee, JM | 1 |
| Liu, TY | 1 |
| Wu, DC | 1 |
| Tang, HC | 1 |
| Leh, J | 1 |
| Wu, MT | 1 |
| Hsu, HH | 1 |
| Huang, PM | 1 |
| Chen, JS | 1 |
| Lee, CJ | 1 |
| Lee, YC | 1 |
2 other studies available for safrole and Cancer of Esophagus
| Article | Year |
|---|---|
TOXIC PROPERTIES OF COMPOUNDS RELATED TO SAFROLE.
Topics: Animals; Carcinogens; Dogs; Esophageal Neoplasms; Guinea Pigs; Liver Neoplasms; Mice; Neoplasms; Neo | 1965 |
Safrole-DNA adducts in tissues from esophageal cancer patients: clues to areca-related esophageal carcinogenesis.
Topics: Aged; Alcohol Drinking; Animals; Areca; Cell Line; DNA Adducts; Esophageal Neoplasms; Esophagus; Fem | 2005 |