Page last updated: 2024-11-04

safrole and Bacteremia

safrole has been researched along with Bacteremia in 1 studies

Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.

Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Grillo, S1
Cuervo, G1
Carratala, J1
San-Juan, R1
Aguado, JM1
Morata, L1
Gomez-Zorrilla, S1
López-Contreras, J1
Gasch, O1
Gomila-Grange, A1
Iftimie, S1
Garcia-Pardo, G1
Calbo, E1
Boix-Palop, L1
Oriol, I1
Jover-Sáenz, A1
López-Cortés, LE1
Euba, G1
Aguirregabiria, M1
Garcia-Pais, MJ1
Gioia, F1
Paño, JR1
Pedro-Botet, ML1
Benítez, RM1
Pérez-Rodríguez, MT1
Meije, Y1
Loeches-Yagüe, MB1
Horna, G1
Berbel, D1
Domínguez, MÁ1
Padullés, A1
Cobo, S1
Hereu, P1
Videla, S1
Tebe, C1
Pallarés, N1
Miro, JM1
Pujol, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multicenter, Randomised, Open-label Phase III-IV Study to Evaluate the Efficacy of Cloxacillin and Fosfomycin Combination Versus Cloxacillin Monotherapy in Patients With Methicillin-susceptible Staphylococcus Aureus Bacteraemia: SAFO Trial[NCT03959345]Phase 4215 participants (Actual)Interventional2019-05-31Terminated (stopped due to Data safety and monitoring board(DSMB) have been performed when half of sample size (SS)have been reached. Recruitment was slower than expected so SS was recalculated. After analysis of data, DSMB recommended to stop study.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for safrole and Bacteremia

ArticleYear
Multicentre, randomised, open-label, phase IV-III study to evaluate the efficacy of cloxacillin plus fosfomycin versus cloxacillin alone in adult patients with methicillin-susceptible
    BMJ open, 2021, 08-05, Volume: 11, Issue:8

    Topics: Adult; Bacteremia; Cloxacillin; Fosfomycin; Humans; Methicillin; Multicenter Studies as Topic; Rando

2021