safrole has been researched along with Adenoma in 4 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Adenoma: A benign epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A systematic, ultrastructural analysis wsa performed on safrole-induced hepatocellular adenomas and hepatocellular carcinoma(s) (HPC) in BALB/c mice." | 7.66 | Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas. ( Hinton, DE; Klaunig, JE; Lipsky, MM; Trump, BF, 1981) |
| "A systematic, ultrastructural analysis wsa performed on safrole-induced hepatocellular adenomas and hepatocellular carcinoma(s) (HPC) in BALB/c mice." | 3.66 | Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas. ( Hinton, DE; Klaunig, JE; Lipsky, MM; Trump, BF, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lipsky, MM | 3 |
| Hinton, DE | 3 |
| Klaunig, JE | 3 |
| Trump, BF | 3 |
| Goldblatt, PJ | 1 |
1 review available for safrole and Adenoma
| Article | Year |
|---|---|
Safrole, isosafrole and dihydrosafrole.
Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Cricetin | 1976 |
3 other studies available for safrole and Adenoma
| Article | Year |
|---|---|
Biology of hepatocellular neoplasia in the mouse. I. Histogenesis of safrole-induced hepatocellular carcinoma.
Topics: Adenoma; Animals; Body Weight; Dioxoles; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inb | 1981 |
Biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis of BALB/c mouse liver during safrole-induced carcinogenesis.
Topics: Adenoma; Animals; Dioxoles; Histocytochemistry; Iron; Kupffer Cells; Liver; Liver Neoplasms, Experim | 1981 |
Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas.
Topics: Adenoma; Animals; Cell Nucleus; Cytoplasm; Dioxoles; Endoplasmic Reticulum; Liver Neoplasms, Experim | 1981 |