safrole has been researched along with Acute Liver Injury, Drug-Induced in 5 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previously it was shown that methylenedioxybenzenes (MDBs), particularly isosafrole, were highly effective at preventing CCl4-induced liver necrosis in vivo (Z." | 3.69 | The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants. ( Khan, S; O'Brien, PJ; Zhao, ZS, 1997) |
| "Multiple doses of beta-naphthoflavone to iron-loaded C57BL/10ScSn mice for 6 weeks caused inhibition of hepatic uroporphyrinogen decarboxylase and a porphyria indistinguishable from that previously only reported for polyhalogenated aromatic chemicals." | 3.67 | Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. ( Francis, JE; Smith, AG, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, AH | 1 |
| Zhang, L | 1 |
| Zhi, DX | 1 |
| Liu, WL | 1 |
| Gao, X | 1 |
| He, X | 1 |
| Jin, M | 1 |
| Kijima, A | 1 |
| Suzuki, Y | 1 |
| Hibi, D | 1 |
| Inoue, T | 1 |
| Ishii, Y | 1 |
| Nohmi, T | 1 |
| Nishikawa, A | 1 |
| Ogawa, K | 1 |
| Umemura, T | 1 |
| Zhao, ZS | 1 |
| Khan, S | 1 |
| O'Brien, PJ | 1 |
| Crampton, RF | 1 |
| Gray, TJ | 1 |
| Grasso, P | 1 |
| Parke, DV | 1 |
| Francis, JE | 1 |
| Smith, AG | 1 |
5 other studies available for safrole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole.
Topics: Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzym | 2018 |
Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; De | 2011 |
The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1997 |
Long-term studies on chemically induced liver enlargement in the rat. II. Transient induction of microsomal enzymes leading to liver damage and nodular hyperplasia produced by safrole and Ponceau MX.
Topics: Animals; Azo Compounds; Chemical and Drug Induced Liver Injury; Diet; Dioxoles; Enzyme Induction; Fe | 1977 |
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Che | 1987 |