safrole has been researched along with Absence Seizure in 2 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we report that seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase (LDH), a component of the astrocyte-neuron lactate shuttle." | 1.42 | Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. ( Inoue, T; Katsu, T; Lee, S; Otsuki, T; Sada, N, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scharfman, HE | 1 |
| Sada, N | 1 |
| Lee, S | 1 |
| Katsu, T | 1 |
| Otsuki, T | 1 |
| Inoue, T | 1 |
2 other studies available for safrole and Absence Seizure
| Article | Year |
|---|---|
Neuroscience. Metabolic control of epilepsy.
Topics: Animals; Anticonvulsants; Dioxolanes; Enzyme Inhibitors; L-Lactate Dehydrogenase; Safrole; Seizures | 2015 |
Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy.
Topics: Animals; Anticonvulsants; Dioxolanes; Disease Models, Animal; Enzyme Inhibitors; L-Lactate Dehydroge | 2015 |