safrole has been researched along with Abnormalities, Autosome in 3 studies
Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Safrole-DNA adducts were detected by a nuclease P1-enhanced 32P-post-labeling assay in isolated hepatocytes from the rats." | 1.30 | In vivo genotoxicity and DNA adduct levels in the liver of rats treated with safrole. ( Asakura, S; Daimon, H; Sagami, F; Sawada, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tayama, S | 1 |
| Daimon, H | 2 |
| Sawada, S | 2 |
| Asakura, S | 2 |
| Sagami, F | 2 |
3 other studies available for safrole and Abnormalities, Autosome
| Article | Year |
|---|---|
Cytogenetic effects of piperonyl butoxide and safrole in CHO-K1 cells.
Topics: Animals; CHO Cells; Chromatography, High Pressure Liquid; Chromosome Aberrations; Cricetinae; Male; | 1996 |
Analysis of cytogenetic effects and DNA adduct formation induced by safrole in Chinese hamster lung cells.
Topics: Animals; Carcinogens; Cells, Cultured; Chromosome Aberrations; Cricetinae; DNA Adducts; Dose-Respons | 1997 |
In vivo genotoxicity and DNA adduct levels in the liver of rats treated with safrole.
Topics: Animals; Carcinogens; Cells, Cultured; Chromosome Aberrations; DNA Adducts; Dose-Response Relationsh | 1998 |