safingol has been researched along with Benign Neoplasms in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amin, S; Plano, D; Sharma, AK | 1 |
| Allegood, JC; Ambrosini, G; Coward, J; Haimovitz-Friedman, A; Merrill, AH; Musi, E; Schwartz, GK; Truman, JP; Wang, E | 1 |
| Futerman, AH; Levy, M | 1 |
| Cane, LM; Carvajal, RD; Dickson, MA; Gonen, M; Merrill, AH; Schwartz, GK | 1 |
| Chiu, GN; Lin, H; Ling, LU; Tan, KB | 1 |
| Hanada, K; Pelayo, H; Schmelz, E; Separovic, D; Wispriyono, B | 1 |
| Casper, ES; Kelsen, DP; Mullen, E; Saltz, L; Schwartz, GK; Spiess, T; Storniolo, AM; Venuti, R; Ward, D; Woodworth, J; Zervos, P | 1 |
| Billups, C; Cabot, MC; Maurer, BJ; Melton, L; Reynolds, CP | 1 |
| Cabot, MC; Litvak, DA; Senchenkov, A | 1 |
| Dyatlovitskaya, EV; Kandyba, AG; Kozlov, AM; Somova, OG | 1 |
3 review(s) available for safingol and Benign Neoplasms
| Article | Year |
|---|---|
Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors.
Topics: Clofibrate; Drug Combinations; Enzyme Inhibitors; Humans; Isoenzymes; Lysophospholipids; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Practolol; Sphingosine | 2014 |
Mammalian ceramide synthases.
Topics: Animals; Gene Expression Regulation, Enzymologic; Humans; Membrane Proteins; Neoplasms; Sphingosine; Sphingosine N-Acyltransferase; Tumor Suppressor Proteins | 2010 |
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
Topics: Animals; Antineoplastic Agents; Apoptosis; Ceramides; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucosylceramides; Humans; Neoplasms; Signal Transduction; Sphingomyelins; Sphingosine | 2001 |
2 trial(s) available for safingol and Benign Neoplasms
| Article | Year |
|---|---|
A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatigue; Female; Humans; Lymphopenia; Lysophospholipids; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Treatment Outcome | 2011 |
A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Leukopenia; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Pilot Projects; Protein Kinase C; Regression Analysis; Sphingosine; Thrombocytopenia | 1997 |
5 other study(ies) available for safingol and Benign Neoplasms
| Article | Year |
|---|---|
Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.
Topics: Acridine Orange; Autophagy; Cell Count; Cell Line, Tumor; Cell Survival; Chromatography, Liquid; Fluorescent Antibody Technique; Humans; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; RNA, Small Interfering; Sphingolipids; Sphingosine; Tandem Mass Spectrometry; TOR Serine-Threonine Kinases | 2009 |
The role of reactive oxygen species and autophagy in safingol-induced cell death.
Topics: Autophagy; Cell Death; Cell Line, Tumor; Cells; HT29 Cells; Humans; Neoplasms; Reactive Oxygen Species; Sphingosine | 2011 |
A role for the de novo sphingolipids in apoptosis of photosensitized cells.
Topics: Acyltransferases; Animals; Apoptosis; Carboxylic Acids; Caspases; CHO Cells; Cricetinae; Cytochrome c Group; Fatty Acids, Monounsaturated; Fumonisins; Histidine; Humans; Indoles; Jurkat Cells; Kinetics; Mitochondria; Models, Chemical; Neoplasms; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Tumor Cells, Cultured | 2002 |
Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Ceramides; Drug Synergism; Enzyme Inhibitors; Estrogen Receptor Modulators; Fenretinide; Glucosyltransferases; Humans; Morpholines; Necrosis; Neoplasms; Protein Kinase C; Sphingosine; Tamoxifen; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Sphinganine in sphingomyelins of tumors and mouse regenerating liver.
Topics: Animals; Hepatectomy; Humans; Liver; Liver Regeneration; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms; Sphingomyelins; Sphingosine | 2001 |