sacubitril and Renal-Insufficiency

Salt-sensitive (SS) hypertension is accompanied with severe cardiorenal complications. In this condition, elevated blood pressure (BP) resulting from salt retention is associated with counterintuitively lower levels of atrial natriuretic peptide (ANP). In plasma, ANP is degraded by the neprilysin; therefore, pharmacological inhibition of this metalloprotease (i.e., with sacubitril) can be employed to increase ANP level. We have shown earlier that sacubitril in combination with valsartan (75 μg/day each) had beneficial effects on renal function in Dahl SS rats. The goal of this study was to evaluate the effects of a higher dose of sacubitril on renal damage in this model. To induce hypertension, male Dahl SS rats were fed a 4% NaCl diet (HS) for 21 days, and were administered sacubitril (125 μg/day) or vehicle

Topics: Aminobutyrates; Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension; Kidney Glomerulus; Male; Neprilysin; Rats; Rats, Inbred Dahl; Renal Insufficiency