saccharin has been researched along with Weight Gain in 29 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Sucrose and saccharin consumption led to increased body weight across the 12-wk intervention (Δweight = +1." | 9.30 | A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. ( Higgins, KA; Mattes, RD, 2019) |
| "In a previous study, we showed that saccharin can induce weight gain when compared with sucrose in Wistar rats despite similar total caloric intake." | 7.83 | Sweet taste of saccharin induces weight gain without increasing caloric intake, not related to insulin-resistance in Wistar rats. ( Ballard, CR; Bertoluci, MC; de Matos Feijó, F; Foletto, KC; Marques Ribeiro, MF; Melo Batista, BA; Neves, AM, 2016) |
| " Sucrose and saccharin consumption led to increased body weight across the 12-wk intervention (Δweight = +1." | 5.30 | A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. ( Higgins, KA; Mattes, RD, 2019) |
| "In a previous study, we showed that saccharin can induce weight gain when compared with sucrose in Wistar rats despite similar total caloric intake." | 3.83 | Sweet taste of saccharin induces weight gain without increasing caloric intake, not related to insulin-resistance in Wistar rats. ( Ballard, CR; Bertoluci, MC; de Matos Feijó, F; Foletto, KC; Marques Ribeiro, MF; Melo Batista, BA; Neves, AM, 2016) |
| " Our results indicate that intermittent and daily SDS procedures attenuated body weight gain, induced adrenal hypertrophy, and reduced the preference for saccharin, a sweet solution preferred by normal rats." | 3.77 | 5-HT1B mRNA expression after chronic social stress. ( Furay, AR; McDevitt, RA; Miczek, KA; Neumaier, JF, 2011) |
| " Our results demonstrated that chronic intake of sweeteners significantly impaired PAL performance in all groups." | 1.48 | Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study. ( Erbaş, O; Erdoğan, MA; Eroglu, HA; Gürkan, FT; Khalilnezhad, A; Solmaz, V; Taskiran, D; Yiğittürk, G, 2018) |
| " The present set of experiments examined the dose-response and sex-related differences induced by repeated binge ethanol administration during adolescence on sweetened ethanol (Experiment 1) or saccharin (Experiment 2) intake in young adulthood." | 1.36 | Repeated binge ethanol administration during adolescence enhances voluntary sweetened ethanol intake in young adulthood in male and female rats. ( Alipour, KK; Kirstein, CL; Maldonado-Devincci, AM; Michael, LA, 2010) |
| "Body weight gains were also greater in the sugar-fat group than in the fat and sugar groups." | 1.28 | Hyperphagia in rats produced by a mixture of fat and sugar. ( Lucas, F; Sclafani, A, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.90) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Batten, SR | 1 |
| Hicks, KB | 1 |
| Dwoskin, LP | 1 |
| Beckmann, JS | 1 |
| Erbaş, O | 1 |
| Erdoğan, MA | 1 |
| Khalilnezhad, A | 1 |
| Solmaz, V | 1 |
| Gürkan, FT | 1 |
| Yiğittürk, G | 1 |
| Eroglu, HA | 1 |
| Taskiran, D | 1 |
| Zhao, X | 1 |
| Yan, J | 1 |
| Chen, K | 1 |
| Song, L | 1 |
| Sun, B | 1 |
| Wei, X | 1 |
| Higgins, KA | 1 |
| Mattes, RD | 1 |
| Khan, SA | 1 |
| Foletto, KC | 2 |
| Melo Batista, BA | 1 |
| Neves, AM | 2 |
| de Matos Feijó, F | 1 |
| Ballard, CR | 2 |
| Marques Ribeiro, MF | 1 |
| Bertoluci, MC | 2 |
| Boakes, RA | 1 |
| Kendig, MD | 1 |
| Martire, SI | 1 |
| Rooney, KB | 1 |
| Sterk, A | 1 |
| Schlegel, P | 2 |
| Mul, AJ | 1 |
| Ubbink-Blanksma, M | 1 |
| Bruininx, EM | 1 |
| Taraschenko, OD | 1 |
| Rubbinaccio, HY | 1 |
| Maisonneuve, IM | 1 |
| Glick, SD | 1 |
| Jiang, KJ | 1 |
| Jiao, HC | 1 |
| Song, ZG | 1 |
| Yuan, L | 1 |
| Zhao, JP | 1 |
| Lin, H | 1 |
| Schweizer, MC | 1 |
| Henniger, MS | 1 |
| Sillaber, I | 1 |
| Bursey, RG | 1 |
| Swithers, SE | 3 |
| Baker, CR | 1 |
| Davidson, TL | 2 |
| Maldonado-Devincci, AM | 1 |
| Alipour, KK | 1 |
| Michael, LA | 1 |
| Kirstein, CL | 1 |
| Martin, AA | 1 |
| Clark, KM | 1 |
| Laboy, AF | 1 |
| Furay, AR | 1 |
| McDevitt, RA | 1 |
| Miczek, KA | 1 |
| Neumaier, JF | 1 |
| Feijó, FM | 1 |
| Batista, BAM | 1 |
| Ribeiro, MFM | 1 |
| Sample, CH | 1 |
| Katz, DP | 1 |
| Reid, ML | 1 |
| Hubbell, CL | 1 |
| Reid, LD | 1 |
| Petrov, ES | 1 |
| Nizhnikov, ME | 1 |
| Kozlov, AP | 1 |
| Varlinskaya, EI | 1 |
| Kramskaya, TA | 1 |
| Spear, NE | 1 |
| McMeniman, JP | 1 |
| Rivera, JD | 1 |
| Rounds, W | 1 |
| Galyean, ML | 1 |
| Wang, C | 1 |
| Bomberg, E | 1 |
| Levine, A | 1 |
| Billington, C | 1 |
| Kotz, CM | 1 |
| Sclafani, A | 2 |
| Lucas, F | 2 |
| Ackroff, K | 1 |
| Dib, K | 1 |
| Oget, I | 1 |
| Wrisez, F | 1 |
| El Jamali, A | 1 |
| Aguie-Aguie, G | 1 |
| Correze, C | 1 |
| Lambert, B | 1 |
| Yeomans, MR | 1 |
| Clifton, PG | 1 |
| Touzani, K | 1 |
| Velley, L | 1 |
| Anderson, RL | 1 |
| Lefever, FR | 1 |
| Miller, NS | 1 |
| Maurer, JK | 1 |
| Balog, JM | 1 |
| Millar, RI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Low Calorie Sweetener Consumption on Body Weight, Body Composition, Appetite, and Energy Intake[NCT02928653] | 187 participants (Actual) | Interventional | 2015-12-31 | Completed | |||
| Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility[NCT02890108] | 10 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for saccharin and Weight Gain
| Article | Year |
|---|---|
Artificial sweeteners: safe or unsafe?
Topics: Aspartame; Diabetes Mellitus, Type 2; Dipeptides; Humans; Neoplasms; Obesity; Saccharin; Sucrose; Sw | 2015 |
2 trials available for saccharin and Weight Gain
| Article | Year |
|---|---|
A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity.
Topics: Adult; Aspartame; Beverages; Body Mass Index; Body Weight; Diet; Dietary Sucrose; Diterpenes, Kauran | 2019 |
Effects of an artificial sweetener on health, performance, and dietary preference of feedlot cattle.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Diet; Feeding Behavior; Fo | 2006 |
26 other studies available for saccharin and Weight Gain
| Article | Year |
|---|---|
Toward isolating reward changes in diet-induced obesity: A demand analysis.
Topics: Animals; Diet, High-Fat; Male; Models, Economic; Obesity; Rats; Reward; Saccharin; Sucrose; Weight G | 2020 |
Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study.
Topics: Animals; Aspartame; Avoidance Learning; Blood Glucose; Cell Count; Cognition; Drinking Water; Glial | 2018 |
Effects of saccharin supplementation on body weight, sweet receptor mRNA expression and appetite signals regulation in post-weanling rats.
Topics: Animals; Appetite; Eating; Female; Gene Expression Regulation; Hypothalamus; Male; Rats; Receptors, | 2018 |
Sweet taste of saccharin induces weight gain without increasing caloric intake, not related to insulin-resistance in Wistar rats.
Topics: Animals; Blood Glucose; Drinking Water; Energy Intake; Fasting; Glucose Transporter Type 2; Insulin; | 2016 |
Sweetening yoghurt with glucose, but not with saccharin, promotes weight gain and increased fat pad mass in rats.
Topics: Adipose Tissue, White; Adiposity; Animals; Energy Intake; Female; Food Preferences; Glucose; Humans; | 2016 |
Effects of sweeteners on individual feed intake characteristics and performance in group-housed weanling pigs.
Topics: Animals; Eating; Feces; Female; Housing, Animal; Male; Random Allocation; Saccharin; Sweetening Agen | 2008 |
18-methoxycoronaridine: a potential new treatment for obesity in rats?
Topics: Animal Feed; Animals; Appetite Regulation; Conditioning, Operant; Dopamine; Dose-Response Relationsh | 2008 |
Corticosterone administration and dietary glucose supplementation enhance fat accumulation in broiler chickens.
Topics: Adipose Tissue; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Composition; | 2008 |
Chronic mild stress (CMS) in mice: of anhedonia, 'anomalous anxiolysis' and activity.
Topics: Animals; Anxiety; Body Weight; Chronic Disease; Consummatory Behavior; Drinking Behavior; Light; Mal | 2009 |
Letter to Fowler et al., 2008. No valid association between artificial sweeteners and weight gain.
Topics: Aspartame; Body Mass Index; Hispanic or Latino; Humans; Obesity; Reproducibility of Results; Risk Fa | 2009 |
General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.
Topics: Analysis of Variance; Animals; Body Weight; Diet; Energy Intake; Fabaceae; Feeding Behavior; Female; | 2009 |
Repeated binge ethanol administration during adolescence enhances voluntary sweetened ethanol intake in young adulthood in male and female rats.
Topics: Age Factors; Animals; Ethanol; Female; Male; Rats; Rats, Sprague-Dawley; Saccharin; Sweetening Agent | 2010 |
Body weight gain in rats consuming sweetened liquids. Effects of caffeine and diet composition.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Diet, Fat-Restricted; Dietary Fats; Dietary Su | 2010 |
5-HT1B mRNA expression after chronic social stress.
Topics: Adrenal Glands; Anhedonia; Animals; Chronic Disease; Corpus Striatum; Eating; In Situ Hybridization; | 2011 |
Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels.
Topics: Animals; Aspartame; Energy Intake; Energy Metabolism; Male; Rats; Rats, Wistar; Saccharin; Satiation | 2013 |
Influence of ovarian and non-ovarian estrogens on weight gain in response to disruption of sweet taste--calorie relations in female rats.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Body Weight; Energy Intake; Energy Metabolism; Female; N | 2013 |
A pharmacological dose of estradiol can enhance appetites for alcoholic beverages.
Topics: Alcohol Drinking; Animals; Estradiol; Female; Rats; Rats, Sprague-Dawley; Saccharin; Stimulation, Ch | 2003 |
Repetitive exposures to a surrogate nipple providing nutritive and non-nutritive fluids: effects on suckling behavior of the newborn rat.
Topics: Animals; Animals, Newborn; Animals, Suckling; Bottle Feeding; Conditioning, Psychological; Feeding B | 2004 |
Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake.
Topics: Animals; Brain-Derived Neurotrophic Factor; Dose-Response Relationship, Drug; Eating; Energy Intake; | 2007 |
The importance of taste and palatability in carbohydrate-induced overeating in rats.
Topics: Animals; Dietary Carbohydrates; Drinking; Eating; Energy Intake; Female; Food Preferences; Glucans; | 1996 |
Effects of sodium saccharin diet on fat-cell lipolysis: evidence for increased function of the adenylyl cyclase catalyst.
Topics: Adenylyl Cyclases; Adipocytes; Animals; Cell Membrane; Cyclic AMP; Diet; Drinking; Eating; GTP-Bindi | 1996 |
Exposure to sweetened solutions enhances the anorectic effect of naloxone but not d-fenfluramine.
Topics: Analysis of Variance; Animals; Appetite Depressants; Eating; Fenfluramine; Male; Naloxone; Narcotic | 1997 |
Ibotenic acid lesion of the hypothalamic paraventricular nucleus produces weight gain but modifies neither preference nor aversion for saccharin.
Topics: Animals; Avoidance Learning; Brain Mapping; Conditioning, Classical; Dose-Response Relationship, Dru | 1992 |
Hyperphagia in rats produced by a mixture of fat and sugar.
Topics: Animals; Corn Oil; Diet; Emulsions; Energy Intake; Female; Food Preferences; Hyperphagia; Plant Oils | 1990 |
Comparison of the bladder response to indole and sodium saccharin ingestion by male rats.
Topics: Animals; Diuresis; Drinking; Drug Interactions; Eating; Indican; Indoles; Male; Organ Size; Rats; Sa | 1989 |
Influence of the sense of taste on broiler chick feed consumption.
Topics: Animal Feed; Animals; Aspartame; Chickens; Citrates; Citric Acid; Eating; Male; Quinine; Saccharin; | 1989 |