saccharin has been researched along with Urinary Bladder Neoplasms in 185 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ulceration of the bladder, induced by cyclophosphamide (CP) or freezing, followed by sodium saccharin in the diet results in the induction of bladder cancer." | 7.67 | Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin. ( Cohen, SM; Hasegawa, R; Murasaki, G; Suzuki, T, 1984) |
| "Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection." | 7.67 | Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985) |
| "An epidemiologic study designed to elucidate the possible roles of the artificial sweeteners saccharin and cyclamate in human urinary bladder cancer was recently completed." | 7.66 | Saccharin, cyclamate, and human bladder cancer. No evidence of an association. ( Clark, JP; Kessler, II, 1978) |
| "Protein and DNA were extracted from 89 bladder tumors [87 transitional cell carcinomas (TCC), 1 papilloma, and 1 sarcoma] from 86 rats p21 expression was examined by Western blotting using a monoclonal antibody against p21 (NCC-RAS-004)." | 5.28 | H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts. ( Cohen, SM; Fujii, H; Garland, EM; Macatee, TL; Mann, AM; Masui, T; Okamura, T; Pelling, JC, 1991) |
| " None of the incidences or numbers of these lesions were significantly different in any of the other saccharin-treated groups when compared to the group treated with BBN alone except for the incidences of two types of hyperplasias in the female rats dosed with 10,000 ppm saccharin." | 5.26 | Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. ( Hagiwara, A; Imaida, K; Ito, N; Nakanishi, K; Shibata, M; Tatematsu, M, 1980) |
| "The estimated relative risk of bladder cancer in diabetics was 0-98 with 95% confidence limits 0-70-1-38." | 5.25 | Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits. ( Armstrong, B; Doll, R, 1975) |
| " Ulceration of the bladder, induced by cyclophosphamide (CP) or freezing, followed by sodium saccharin in the diet results in the induction of bladder cancer." | 3.67 | Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin. ( Cohen, SM; Hasegawa, R; Murasaki, G; Suzuki, T, 1984) |
| "It is suggested that the induction of bladder cancer in male rats by saccharin is related to the integrity of the urothelial permeability barrier and that, in the Sprague-Dawley rat, saccharin is unable to attain a sufficient concentration in the urothelium if the barrier remains intact." | 3.67 | The mode of carcinogenic action of saccharin. ( Clayson, DB, 1984) |
| "Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection." | 3.67 | Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985) |
| "An epidemiologic study designed to elucidate the possible roles of the artificial sweeteners saccharin and cyclamate in human urinary bladder cancer was recently completed." | 3.66 | Saccharin, cyclamate, and human bladder cancer. No evidence of an association. ( Clark, JP; Kessler, II, 1978) |
| "Saccharin is known to have a tumor-promoting effect on bladder cancer in rats, but its mechanism of action is unknown." | 3.66 | Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens. ( Kakizoe, T; Kawachi, T; Komatsu, H; Niijima, T; Sugimura, T, 1981) |
| "A positive association between the use of artificial sweetners, particularly saccharin, and risk of bladder cancer in males has been observed in a case-control study of 480 men and 152 women in three Provinces in Canada." | 3.65 | Artificial sweeteners and human bladder cancer. ( Burch, JD; Chambers, LW; Fodor, G; Gordon, P; Howe, GR; Miller, AB; Morrison, B; Weldon, L; Winsor, GM, 1977) |
| " There was a significant dose-response relationship with lifelong coffee drinking and alcohol consumption; however the risk estimates were only significantly elevated for the heaviest drinkers." | 2.67 | Relative importance of risk factors in bladder carcinogenesis: some new results about Mediterranean habits. ( Bontoux, J; Daurès, JP; Festy, B; Grémy, F; Momas, I, 1994) |
| " Cell proliferation can affect the dose-response curve for genotoxic carcinogens and is the basis for carcinogenicity by nongenotoxic agents." | 2.39 | Role of cell proliferation in regenerative and neoplastic disease. ( Cohen, SM, 1995) |
| "Sodium saccharin (NaSac) produces bladder tumors consistently in male rats only after lifetime exposure that begins at birth." | 2.39 | Saccharin mechanistic data and risk assessment: urine composition, enhanced cell proliferation, and tumor promotion. ( Whysner, J; Williams, GM, 1996) |
| " The carcinogenic dose-response relationship for genotoxic chemicals (such as 2-acetylaminofluorene) was also due in part to increased cell proliferation." | 2.38 | Cell proliferation in carcinogenesis. ( Cohen, SM; Ellwein, LB, 1990) |
| "Limonene failed to increase the mutant frequency in the liver or kidney of the rats, and sodium saccharin failed to increase the mutant frequency in the liver or bladder of the rats." | 1.31 | The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats. ( Ashby, J; Piegorsch, W; Schmezer, P; Tinwell, H; Turner, SD, 2001) |
| " The public health implication of this lack of linearity in the low-dose area of the dose-response curve raises the question of whether low doses of carcinogens will reduce cancer risk." | 1.30 | Can the concept of hormesis Be generalized to carcinogenesis? ( Baldwin, LA; Calabrese, EJ, 1998) |
| "History of urinary tract infections and bladder stones was associated with increasing relative risks for advanced tumor stage." | 1.29 | Associations between bladder cancer risk factors and tumor stage and grade at diagnosis. ( Hartge, P; Hoover, RN; Kantor, AF; Linehan, WM; Lynch, C; Silverman, DT; Sturgeon, SR, 1994) |
| "A co-carcinogenicity experiment was conducted with female Sprague-Dawley rats in which the effects of short-term sodium saccharin dosing and initiation with a direct-acting carcinogen were examined in the urinary bladder." | 1.29 | Study of sodium saccharin co-carcinogenicity in the rat. ( Allen, RR; Gaylor, DW; Kadlubar, FF; Sheldon, WG; West, RW, 1994) |
| "The ANFT-treated cells followed by control medium or urea and cells treated with ANFT, NaS and urea were tumorigenic when transplanted to nude mice, whereas NaS or ANFT followed by NaS treatment were not." | 1.28 | In vitro transformation of rat bladder epithelium by 2-amino-4-(5-nitro-2-furyl)thiazole. ( Borgeson, CD; Chlapowski, FJ; Cohen, SM; Mann, AM; Masui, T; Okamura, T, 1991) |
| "Protein and DNA were extracted from 89 bladder tumors [87 transitional cell carcinomas (TCC), 1 papilloma, and 1 sarcoma] from 86 rats p21 expression was examined by Western blotting using a monoclonal antibody against p21 (NCC-RAS-004)." | 1.28 | H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts. ( Cohen, SM; Fujii, H; Garland, EM; Macatee, TL; Mann, AM; Masui, T; Okamura, T; Pelling, JC, 1991) |
| "The BBN model of bladder cancer is an excellent model of human urinary bladder cancer and has already led to a greater knowledge of its pathogenesis." | 1.27 | Modifying factors in urinary bladder carcinogenesis. ( Fukushima, S; Hasegawa, R; Imaida, K; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " Studies of the dose-response relationships have also shown no consistent pattern." | 1.27 | Saccharin/cyclamates: epidemiological evidence. ( Armstrong, BK, 1985) |
| "Then, the risk of bladder tumors is estimated to be between 0." | 1.27 | Estimates of the risk of bladder tumor promotion by saccharin in rats. ( Gaylor, DW; Kadlubar, FF; West, RW, 1988) |
| "This study analyzes a set of dose-response curves relative to promoter carcinogens administered to experimental animals with or without initiator pretreatment." | 1.27 | Dose-response relationships in rodents of promoter carcinogens: a tentative interpretation of some downward trends. ( Bucchi, AR; Gabriele, M; Lupi, C; Zapponi, GA, 1988) |
| "The relationship between bladder cancer and alcohol consumption was investigated in a case-control study conducted in 506 patients (453 males and 53 females) with diagnoses of papillary urothelial carcinoma during 1978-1982 at "La Paz" hospital (Madrid), and an equal number of controls matched for age, sex and date of admission to the hospital." | 1.27 | Bladder cancer and the consumption of alcoholic beverages in Spain. ( Bravo, MP; Conde, M; Del Rey Calero, J, 1987) |
| "The highest rate for bladder cancer in Latin America has been reported from La Plata, Argentina." | 1.27 | Tobacco smoking, occupational exposure and bladder cancer in Argentina. ( Arslan, A; Castelletto, R; Colanzi, R; Coronel, A; Deamezola, I; Estève, J; Iscovich, J; Muñoz, N; Tassi, V, 1987) |
| "Saccharin has been found to be a carcinogen only in rats and only if administered over two generations." | 1.27 | Saccharin: past, present, and future. ( Cohen, SM, 1986) |
| " Dosed animals were kept in metabolism cages for 48 h to monitor urinary and fecal excretion of the label." | 1.27 | Urinary excretion of orally administered oxalic acid in saccharin and o-phenylphenol-fed NMRI mice. ( Salminen, E; Salminen, S, 1986) |
| "FANFT was administered in the diet at a level of 0." | 1.27 | Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogenesis in male F344 rats. ( Cohen, SM; Hasegawa, R; Johansson, SL; Sakata, T; Zenser, TV, 1986) |
| "Saccharin has been reported to induce urinary bladder tumors in multigeneration rat feeding studies and to promote bladder carcinogenesis in rats initiated with known bladder carcinogens." | 1.27 | The effects of saccharin on the development of neoplastic lesions initiated with N-methyl-N-nitrosourea in the rat urothelium. ( Delongchamp, RR; Gaylor, DW; Haskin, MG; Kadlubar, FF; Sheldon, WG; West, RW, 1986) |
| "The effects of long-term administration of sodium saccharin on the urinary bladder and stomach of F344 rats were investigated." | 1.27 | Morphologic changes in the urinary bladder and stomach after long-term administration of sodium saccharin in F344 rats. ( Arai, M; Hibino, T; Hirasawa, Y, 1985) |
| " Generally, carcinogenicity is a result of the intrinsic property of a chemical and is independent of dosage and duration of exposure; however, the detection of carcinogenicity is dose-related." | 1.26 | Experimental identification of genitourinary carcinogens. ( Sontag, JM, 1980) |
| " None of the incidences or numbers of these lesions were significantly different in any of the other saccharin-treated groups when compared to the group treated with BBN alone except for the incidences of two types of hyperplasias in the female rats dosed with 10,000 ppm saccharin." | 1.26 | Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. ( Hagiwara, A; Imaida, K; Ito, N; Nakanishi, K; Shibata, M; Tatematsu, M, 1980) |
| "A case-control study of bladder cancer in two northern counties of New Jersey was conducted to investigate a tumour that has been considered to be strongly associated with industrial and environmental exposures." | 1.26 | Life time occupation, smoking, caffeine, saccharine, hair dyes and bladder carcinogenesis. ( Ambrose, RB; Fernicola, AR; Louria, DB; Najem, GR; Prusakowski, JM; Seebode, JJ; Thind, IS, 1982) |
| " These elements were divided into 4 general categories: design, including selection of test animals, basal diet, dosage form and doses of test substance, route of administration, and duration of exposure; observations, including gross observations during life and at necropsy, clinical tests, and histopathology; performance, including conduct of the test and animal husbandry; and analytical procedures, including chemical and statistical analyses." | 1.26 | Comparison of studies on saccharin and sodium nitrite. ( Morgenroth, VH; Taylor, JM, 1979) |
| "Saccharin was considerably more potent as a promoting agent than was tryptophan, inducing higher incidences of bladder tumors and having a shorter latent period." | 1.26 | Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis. ( Arai, M; Cohen, SM; Friedell, GH; Jacobs, JB, 1979) |
| "A greater proportion of users among cancer patients than among controls was noted only for cancer of the stomach among women." | 1.26 | Use of artificial sweeteners by cancer patients. ( Morrison, AS, 1979) |
| " Since conversion to cyclohexylamine (CHA) was found to occur in many of the rats, particularly in the higher dosage groups, it was included as an added insult in the diets of about half the animals during the last quarter of the 2-year test period." | 1.25 | Chronic toxicity study of cyclamate: saccharin (10: 1) in rats. ( Carson, S; Cox, GE; Oser, BL; Sternberg, SS; Vogin, EE, 1975) |
| "The estimated relative risk of bladder cancer in diabetics was 0-98 with 95% confidence limits 0-70-1-38." | 1.25 | Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits. ( Armstrong, B; Doll, R, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 151 (81.62) | 18.7374 |
| 1990's | 31 (16.76) | 18.2507 |
| 2000's | 3 (1.62) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoover, RN | 3 |
| Strasser, PH | 1 |
| Arnold, DL | 2 |
| Hicks, RM | 11 |
| Sims, J | 1 |
| Renwick, AG | 1 |
| Hasegawa, R | 10 |
| St John, MK | 2 |
| Cano, M | 2 |
| Issenberg, P | 1 |
| Klein, DA | 1 |
| Walker, BA | 1 |
| Jones, JW | 1 |
| Schnell, RC | 1 |
| Merrick, BA | 1 |
| Davies, MH | 1 |
| Hagiwara, A | 4 |
| Fukushima, S | 15 |
| Kitaori, M | 1 |
| Shibata, M | 4 |
| Ito, N | 13 |
| Sakata, T | 3 |
| Shirai, T | 4 |
| Cohen, SM | 30 |
| Greenfield, RE | 4 |
| Ellwein, LB | 6 |
| Wermut, W | 1 |
| Newell, GR | 2 |
| Ogiso, T | 2 |
| Mommsen, S | 1 |
| Aagaard, J | 1 |
| Sell, A | 1 |
| Suzuki, T | 2 |
| Murasaki, G | 5 |
| Clayson, DB | 1 |
| Van Duuren, BL | 1 |
| Sontag, JM | 1 |
| Nakanishi, K | 6 |
| Imaida, K | 4 |
| Arai, M | 4 |
| Nakanowatari, J | 2 |
| Hibino, T | 2 |
| Okuda, M | 2 |
| Honma, Y | 1 |
| Kakizoe, T | 5 |
| Komatsu, H | 2 |
| Niijima, T | 2 |
| Sugimura, T | 3 |
| Nagase, S | 2 |
| Tsuda, H | 2 |
| Kurata, Y | 2 |
| Tatematsu, M | 2 |
| Tamano, S | 2 |
| Caruthers, JM | 1 |
| Bonneville, MA | 1 |
| Howe, GR | 2 |
| Burch, JD | 2 |
| Goldsmith, DF | 1 |
| Jensen, OM | 2 |
| Kamby, C | 2 |
| Najem, GR | 1 |
| Louria, DB | 1 |
| Seebode, JJ | 1 |
| Thind, IS | 1 |
| Prusakowski, JM | 1 |
| Ambrose, RB | 1 |
| Fernicola, AR | 1 |
| Hirose, M | 2 |
| Hatano, A | 1 |
| Green, U | 1 |
| Schneider, P | 1 |
| Deutsch-Wenzel, R | 1 |
| Brune, H | 1 |
| Althoff, J | 2 |
| Nightingale, EO | 2 |
| Robbins, FC | 2 |
| Friedell, GH | 2 |
| Jacobs, JB | 2 |
| Cartwright, RA | 1 |
| Adib, R | 1 |
| Glashan, R | 1 |
| Gray, BK | 1 |
| Upton, AC | 1 |
| Kawachi, T | 2 |
| Morrison, AS | 2 |
| Buring, JE | 1 |
| Hoover, R | 1 |
| Peto, R | 1 |
| Smith, RJ | 1 |
| Ozonoff, D | 1 |
| Taylor, JM | 2 |
| Weinberger, MA | 1 |
| Friedman, L | 1 |
| Hooson, J | 1 |
| Grasso, P | 1 |
| Chowaniec, J | 6 |
| Brown, AL | 1 |
| Demers, DM | 1 |
| Masui, T | 8 |
| Mann, AM | 4 |
| Borgeson, CD | 2 |
| Garland, EM | 9 |
| Okamura, T | 6 |
| Fujii, H | 2 |
| Pelling, JC | 2 |
| Uwagawa, S | 2 |
| Saito, K | 1 |
| Okuno, Y | 1 |
| Kawasaki, H | 1 |
| Yoshitake, A | 1 |
| Yamada, H | 1 |
| Momas, I | 1 |
| Daurès, JP | 1 |
| Festy, B | 1 |
| Bontoux, J | 1 |
| Grémy, F | 1 |
| West, RW | 3 |
| Sheldon, WG | 2 |
| Gaylor, DW | 3 |
| Allen, RR | 1 |
| Kadlubar, FF | 3 |
| Sturgeon, SR | 1 |
| Hartge, P | 1 |
| Silverman, DT | 1 |
| Kantor, AF | 1 |
| Linehan, WM | 1 |
| Lynch, C | 1 |
| Elcock, M | 1 |
| Morgan, RW | 1 |
| Ogawa, K | 2 |
| Sun, TT | 1 |
| Morimoto, S | 1 |
| Whysner, J | 1 |
| Williams, GM | 1 |
| Anderson, RL | 2 |
| Arnold, LL | 2 |
| Zurlo, J | 1 |
| Squire, RA | 1 |
| Calabrese, EJ | 1 |
| Baldwin, LA | 1 |
| Pines, WL | 1 |
| Glick, N | 1 |
| Ito, M | 1 |
| Shaw, RA | 1 |
| Cohen, S | 1 |
| Turner, SD | 1 |
| Tinwell, H | 1 |
| Piegorsch, W | 1 |
| Schmezer, P | 1 |
| Ashby, J | 2 |
| Miller, AB | 1 |
| Morrison, B | 1 |
| Gordon, P | 1 |
| Weldon, L | 1 |
| Chambers, LW | 1 |
| Fodor, G | 1 |
| Winsor, GM | 1 |
| Felice, PR | 1 |
| Thomas, JA | 1 |
| Coulston, F | 1 |
| McChesney, E | 1 |
| Benitz, KF | 1 |
| Buchanan-Davidson, DJ | 1 |
| Styles, JA | 1 |
| Anderson, D | 1 |
| Paton, D | 1 |
| Kolbye, AC | 1 |
| Reuber, MD | 1 |
| Morrison, AB | 1 |
| Morgenroth, VH | 1 |
| Schmähl, D | 1 |
| Kessler, II | 1 |
| Clark, JP | 1 |
| Sullivan, JW | 1 |
| Fossati, C | 1 |
| Boyland, E | 1 |
| Isselbacher, KJ | 1 |
| Cole, P | 1 |
| Walker, AR | 1 |
| Wynder, EL | 1 |
| Weisburger, JH | 1 |
| Swerdlow, J | 1 |
| Cook, CE | 1 |
| Thompson, GR | 2 |
| Becker, BA | 2 |
| Levin, S | 1 |
| Oser, BL | 2 |
| Munro, IC | 1 |
| Moodie, CA | 1 |
| Krewski, D | 1 |
| Grice, HC | 1 |
| Carson, S | 1 |
| Cox, GE | 1 |
| Vogin, EE | 1 |
| Sternberg, SS | 1 |
| Wakefield, J | 1 |
| Armstrong, B | 2 |
| Doll, R | 2 |
| Cardesa, A | 1 |
| Pour, P | 1 |
| Shubik, P | 2 |
| Wolf, H | 1 |
| Yu, A | 1 |
| Hashimura, T | 2 |
| Nishio, Y | 1 |
| Kanamaru, H | 2 |
| Fukuzawa, S | 1 |
| Yoshida, O | 4 |
| Chappel, CI | 2 |
| Macatee, TL | 2 |
| Smith, RA | 2 |
| Homma, Y | 1 |
| Kondo, Y | 1 |
| Aso, Y | 1 |
| Suzuki, M | 1 |
| Wakabayashi, K | 1 |
| Sone, H | 1 |
| Kushida, H | 1 |
| Sugiyama, K | 1 |
| Nagao, M | 1 |
| Shapiro, R | 1 |
| Kraft, PL | 1 |
| Mattson, BJ | 1 |
| Parr, JM | 1 |
| Johansson, SL | 2 |
| Wehner, JM | 1 |
| Khachab, M | 1 |
| Schoenig, GP | 1 |
| St John, M | 1 |
| Chlapowski, FJ | 1 |
| Zenser, TV | 2 |
| Armstrong, BK | 1 |
| Knowles, MA | 1 |
| Jani, H | 1 |
| Norman, JT | 1 |
| Howlett, AR | 1 |
| Spacey, GD | 1 |
| Hodges, GM | 1 |
| Lamm, LM | 1 |
| Reichert, DF | 1 |
| Lamm, DL | 1 |
| Rall, DP | 1 |
| Bittard, M | 1 |
| Takai, K | 1 |
| Tobisu, K | 1 |
| Ohtani, M | 1 |
| Sato, S | 1 |
| Nabors, LO | 1 |
| Bucchi, AR | 1 |
| Gabriele, M | 1 |
| Lupi, C | 1 |
| Zapponi, GA | 1 |
| Alfin-Slater, RB | 1 |
| Pi-Sunyer, FX | 1 |
| Bravo, MP | 1 |
| Del Rey Calero, J | 1 |
| Conde, M | 1 |
| Iscovich, J | 1 |
| Castelletto, R | 1 |
| Estève, J | 1 |
| Muñoz, N | 1 |
| Colanzi, R | 1 |
| Coronel, A | 1 |
| Deamezola, I | 1 |
| Tassi, V | 1 |
| Arslan, A | 1 |
| Salminen, E | 1 |
| Salminen, S | 1 |
| Cohen-Addad, N | 1 |
| Chatterjee, M | 1 |
| Bekersky, I | 1 |
| Blumenthal, HP | 1 |
| Wang, CY | 1 |
| Haskin, MG | 1 |
| Delongchamp, RR | 1 |
| Pusel, P | 1 |
| Schaffer, P | 1 |
| Bollack, C | 1 |
| Di Silverio, F | 1 |
| Bizzarri, M | 1 |
| Chiappini, L | 1 |
| Ottaviano, C | 1 |
| Tenaglia, R | 1 |
| Hirasawa, Y | 1 |
| Rudali, G | 1 |
| Wakefield, JS | 3 |
| Holmberg, B | 1 |
| Crampton, RF | 2 |
| Chowaniec, AJ | 1 |
| Grasset, AV | 1 |
| Bryan, GT | 2 |
| Göttinger, E | 1 |
| Ertürk, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intestinal Sweet Taste Receptor Function and Adaptation to Dietary Sugars and Sweeteners[NCT02835859] | 10 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors[NCT03032640] | 102 participants (Actual) | Interventional | 2017-01-26 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
29 reviews available for saccharin and Urinary Bladder Neoplasms
| Article | Year |
|---|---|
Promotion: is saccharin a promoter in the urinary bladder?
Topics: Animals; Carcinogens; Cell Membrane; Cocarcinogenesis; Enzyme Induction; Epithelium; Humans; Organ C | 1984 |
Toxicology of saccharin.
Topics: Animals; Biological Assay; Drug Contamination; Female; Fetus; Humans; Legislation, Drug; Male; Pregn | 1984 |
Luminal plasma membrane alterations in bladder cancer.
Topics: Animals; Cell Membrane; Cell Membrane Permeability; Cilia; FANFT; Intercellular Junctions; Methylnit | 1980 |
Multistage carcinogenesis in the urinary bladder.
Topics: Animals; Cricetinae; Cyclamates; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; | 1980 |
Promotion in bladder cancer.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Cyclophosphamide; Humans; Hyperplasia; Mice; Neo | 1982 |
Artificial sweeteners in relation to the epidemiology of bladder cancer.
Topics: Adult; Animals; Beverages; Cyclamates; Diabetes Complications; Female; Humans; Male; Retrospective S | 1981 |
Update on artificial sweeteners and bladder cancer.
Topics: Animals; Case-Control Studies; Female; Humans; Male; Rats; Risk Factors; Saccharin; Sex Factors; Spe | 1993 |
Saccharin-induced bladder cancer in rats.
Topics: Animals; Dose-Response Relationship, Drug; Humans; Rats; Risk Assessment; Saccharin; Urinary Bladder | 1995 |
Role of cell proliferation in regenerative and neoplastic disease.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Humans; Regeneration; Risk Assessment; S | 1995 |
Saccharin mechanistic data and risk assessment: urine composition, enhanced cell proliferation, and tumor promotion.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Female; Humans; Male; Rats; Risk Assessm | 1996 |
Effects of diet on urinary bladder carcinogenesis and cancer prevention.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diet; Humans; Mutagens; Saccharin; Urinary Bladder Ne | 1997 |
Calcium phosphate-containing urinary precipitate in rat urinary bladder carcinogenesis.
Topics: Animals; Biphenyl Compounds; Calcium Phosphates; Carcinogens; Chemical Precipitation; Epithelium; Hu | 1999 |
Saccharin and its salts.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cricetinae; Epidemiologic Studies; Female; Food Additives; G | 1999 |
Saccharin and its salts.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cricetinae; Epidemiologic Studies; Female; Food Additives; G | 1999 |
Saccharin and its salts.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cricetinae; Epidemiologic Studies; Female; Food Additives; G | 1999 |
Saccharin and its salts.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cricetinae; Epidemiologic Studies; Female; Food Additives; G | 1999 |
Status report on saccharin in humans.
Topics: Animals; Drug Evaluation, Preclinical; Epidemiologic Methods; Female; Humans; Male; National Institu | 1978 |
[Presence and estimation of environmental carcinogens (author's transl)].
Topics: Animals; Carcinogens, Environmental; Epidemiologic Methods; Food Additives; Mice; Mutagens; Rats; Sa | 1978 |
Carcinogenicity of saccharin.
Topics: Animals; Carcinogens; Diet; Female; Lung Neoplasms; Male; Methylnitrosourea; Mice; Parasitic Disease | 1978 |
Cyclamates: a review of the current position.
Topics: Animals; Carcinogens; Carcinoma, Papillary; Cyclamates; Cyclohexylamines; Diabetes Mellitus, Type 1; | 1975 |
Assessment of the carcinogenicity of non-nutritive sweetners II: Cyclamates and cyclohexylamine.
Topics: Animals; Carcinogens; Cricetinae; Cyclamates; Cyclohexylamines; Dietary Proteins; Drug Interactions; | 1975 |
A review and biological risk assessment of sodium saccharin.
Topics: Animals; Humans; Hydrogen-Ion Concentration; Male; Rats; Risk; Saccharin; Sodium; Urinary Bladder; U | 1992 |
Cancer enhancement by cell proliferation.
Topics: Animals; Cell Division; FANFT; Humans; Models, Biological; Neoplasms; Rats; Saccharin; Urinary Bladd | 1992 |
Cell proliferation in carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Humans; Liver; Liver Neoplasms; Mice; Mi | 1990 |
[Prognosis of primary tumors of the bladder].
Topics: Aged; Alkylating Agents; Amines; Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Clofi | 1985 |
An hypothesis of the mechanism of urinary bladder tumorigenesis in rat ingesting sodium saccharin.
Topics: Animals; Male; Models, Biological; Rats; Saccharin; Urinary Bladder Neoplasms | 1988 |
Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis.
Topics: Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogen | 1986 |
[Chemical factors and cancer of the bladder].
Topics: Amines; Aniline Compounds; Animals; Benzopyrenes; Coffee; Cyclamates; Female; Guinea Pigs; Humans; H | 1974 |
Cyclamate still to the fore.
Topics: Amines; Animals; Blood Pressure; Carbon Isotopes; Chromosome Aberrations; Cricetinae; Cyclamates; Cy | 1972 |
Problems of food additives, with special reference to cyclamates.
Topics: Animals; Bromine; Carcinoma, Papillary; Cyclamates; Food Additives; Food Contamination; Food-Process | 1970 |
The cyclamate story unfolds.
Topics: Animals; Behavior, Animal; Body Weight; Cyclamates; Embryo, Mammalian; Enzyme Induction; Female; Gro | 1970 |
Artificial sweeteners as urinary bladder carcinogens.
Topics: Administration, Oral; Animals; Carcinogens; Carcinoma; Carcinoma, Papillary; Cattle; Cricetinae; Cyc | 1971 |
1 trial available for saccharin and Urinary Bladder Neoplasms
| Article | Year |
|---|---|
Relative importance of risk factors in bladder carcinogenesis: some new results about Mediterranean habits.
Topics: Age Factors; Aged; Alcohol Drinking; Beverages; Case-Control Studies; Coffee; Feeding Behavior; Fran | 1994 |
155 other studies available for saccharin and Urinary Bladder Neoplasms
| Article | Year |
|---|---|
Artificial sweeteners and human bladder cancer. Preliminary results.
Topics: Adult; Aged; Beverages; Carcinogens; Carcinoma; Dietary Carbohydrates; Feeding Behavior; Female; Hum | 1980 |
Saccharin and bladder cancer.
Topics: Beverages; Carcinogens; Dietary Carbohydrates; Female; Humans; Male; Risk; Saccharin; Sex Ratio; Uni | 1980 |
Two-generation saccharin bioassays.
Topics: Animals; History of Medicine; Neoplasms, Experimental; Rats; Research Design; Saccharin; Urinary Bla | 1983 |
The effects of saccharin on the metabolism of dietary tryptophan to indole, a known cocarcinogen for the urinary bladder of the rat.
Topics: Animals; Cecum; Dose-Response Relationship, Drug; Feces; Indican; Intestines; Male; Neoplasms, Exper | 1983 |
Bladder freeze ulceration and sodium saccharin feeding in the rat: examination for urinary nitrosamines, mutagens and bacteria, and effects on hepatic microsomal enzymes.
Topics: Administration, Oral; Aniline Hydroxylase; Animals; Body Weight; Calcium; Carcinogens; Cytochrome P- | 1984 |
Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Topics: Animals; Aspartame; Butylhydroxybutylnitrosamine; Diterpenes; Diterpenes, Kaurane; Glucosides; Hyper | 1984 |
Summation and synergism in the promotion of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine in F344 rats.
Topics: Allopurinol; Animals; Ascorbic Acid; Butylated Hydroxyanisole; Butylhydroxybutylnitrosamine; Drug Sy | 1984 |
Urinary bladder carcinogenesis.
Topics: Animals; Carcinogens; FANFT; Hyperplasia; Male; Models, Biological; Rats; Rats, Inbred F344; Regener | 1984 |
[Saccharin: risks and advantages].
Topics: Energy Intake; Humans; Saccharin; Urinary Bladder Neoplasms | 1983 |
Food additives and coffee as risk factors.
Topics: Animals; Butylated Hydroxytoluene; Coffee; Food Additives; Humans; Neoplasms; Nitrites; Rats; Risk; | 1983 |
Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine.
Topics: Acetazolamide; Allopurinol; Animals; Ascorbic Acid; Body Weight; Butylhydroxybutylnitrosamine; Carci | 1983 |
A case-control study of female bladder cancer.
Topics: Adult; Aged; Coffee; Female; Humans; Middle Aged; Risk; Saccharin; Smoking; Urinary Bladder Neoplasm | 1983 |
Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin.
Topics: Agglutination; Animals; Carcinogens; Concanavalin A; Cyclophosphamide; Dose-Response Relationship, D | 1984 |
The mode of carcinogenic action of saccharin.
Topics: Animals; Carcinogens; Cell Membrane Permeability; Disease Susceptibility; Epithelium; Female; Male; | 1984 |
A general probabilistic model of carcinogenesis: analysis of experimental urinary bladder cancer.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; FANFT; Mathematics; Mitosis; Models, Biologica | 1984 |
Comments on the potential carcinogenicity of saccharin.
Topics: Animals; Carcinogens; Cyclamates; Haplorhini; Humans; Macaca mulatta; Male; Mice; Mutagens; Rats; Ri | 1980 |
Experimental identification of genitourinary carcinogens.
Topics: Amines; Animals; Carcinogens; Cricetinae; Dogs; Epidemiologic Methods; Female; Haplorhini; Humans; M | 1980 |
Co-carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for the urinary bladder.
Topics: Animals; Cocarcinogenesis; Diet; FANFT; Growth; Male; Neoplasms, Experimental; Rats; Saccharin; Thia | 1983 |
Modifying factors in urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Cell Transformation, Neoplastic; Neoplasms, Expe | 1983 |
Differences in susceptibility to sodium saccharin among various strains of rats and other animal species.
Topics: Animals; Body Weight; Cricetinae; Guinea Pigs; Hyperplasia; Male; Mesocricetus; Rats; Rats, Inbred A | 1983 |
Agglutination assay of bladder cells by Concanavalin A proved the high susceptibility of analbuminemic rats to bladder carcinogens.
Topics: 2-Naphthylamine; Agglutination Tests; Aminobiphenyl Compounds; Animals; Butylhydroxybutylnitrosamine | 1983 |
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
Topics: Adenocarcinoma, Papillary; Animals; Cocarcinogenesis; Liver Neoplasms; Male; Methylnitrosourea; Nitr | 1983 |
Promotion in urinary bladder carcinogenesis.
Topics: Animals; Cell Division; Cocarcinogenesis; FANFT; Neoplasms, Experimental; Rats; Saccharin; Ulcer; Ur | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinoma, Papillary; Dose-Response Relationship, Drug; Femal | 1980 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Effect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: Animals; Cell Division; Cocarcinogenesis; Cyclophosphamide; FANFT; Hyperplasia; Male; Rats; Rats, In | 1982 |
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas | 1982 |
Calculation of potential bias in the odds ratio illustrated by a study of saccharin use and bladder cancer.
Topics: Carcinogens; Epidemiologic Methods; Female; Humans; Male; Research Design; Saccharin; Statistics as | 1982 |
Intra-uterine exposure to saccharin and risk of bladder cancer in man.
Topics: Adult; Denmark; Female; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects; Risk; Saccharin; | 1982 |
Life time occupation, smoking, caffeine, saccharine, hair dyes and bladder carcinogenesis.
Topics: Alcohol Drinking; Caffeine; Female; Hair Dyes; Humans; Male; Neoplasms, Multiple Primary; New Jersey | 1982 |
[Intrauterine exposure to saccharine and risk of cancer of the bladder in man].
Topics: Adult; Age Factors; Denmark; Female; Humans; Male; Maternal-Fetal Exchange; Pregnancy; Saccharin; St | 1982 |
Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Cyclamates; FANFT; Male; Neoplasms, Experimental | 1982 |
[Saccharin and bladder cancer].
Topics: Animals; Female; Humans; Male; Rats; Saccharin; Urinary Bladder Neoplasms | 1980 |
Syncarcinogenic action of saccharin or sodium cyclamate in the induction of bladder tumours in MNU-pretreated rats.
Topics: Animals; Body Weight; Carcinogens; Cyclamates; Drug Synergism; Eating; Female; Methylnitrosourea; Ne | 1980 |
Saccharin and society.
Topics: Aged; Carcinogens; Child; Female; Humans; Legislation, Food; Male; Pregnancy; Risk; Saccharin; Unite | 1981 |
Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; FANFT; Male; Neoplasms, Experimental; Rats; | 1981 |
The epidemiology of bladder cancer in West Yorkshire. A preliminary report on non-occupational aetiologies.
Topics: Alcohol Drinking; Coffee; England; Female; Humans; Male; Risk; Saccharin; Sex Factors; Smoking; Urin | 1981 |
Preventive medicine in the workplace--prospects for the 1980s.
Topics: Accidents, Occupational; Animals; Humans; Neoplasms; Neoplasms, Experimental; Neoplasms, Radiation-I | 1981 |
Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens.
Topics: Animals; Butylhydroxybutylnitrosamine; Cell Aggregation; Cell Membrane; Cocarcinogenesis; Concanaval | 1981 |
Artificial sweeteners and cancer of the lower urinary tract.
Topics: Adult; Age Factors; Aged; Beverages; Boston; Cyclamates; Diet; Female; Humans; Male; Middle Aged; Oc | 1980 |
Saccharin--bitter aftertaste?
Topics: Adult; Age Factors; Animals; Carcinogens; Child; Female; Fetus; Humans; Male; Middle Aged; Pregnancy | 1980 |
No evidence found of link between saccharin and cancer.
Topics: Humans; Saccharin; Urinary Bladder Neoplasms | 1980 |
Distorting the epidemiology of cancer: the need for a more balanced overview.
Topics: Carcinogens; Diet; Economics; Environmental Exposure; Humans; Industry; Politics; Saccharin; United | 1980 |
Latest saccharin tests kill FDA proposal.
Topics: Animals; Humans; Public Opinion; Rats; Saccharin; United States; United States Food and Drug Adminis | 1980 |
Artificial sweeteners and bladder cancer.
Topics: Humans; Saccharin; Urinary Bladder Neoplasms | 1980 |
Chronic toxicity and carcinogenicity to the urinary bladder of sodium saccharin in the in utero-exposed rat.
Topics: Animals; Body Weight; Carcinogens; Eating; Female; Maternal-Fetal Exchange; Organ Size; Pregnancy; R | 1980 |
Ortho-toluene sulphonamide and saccharin in the promotion of bladder cancer in the rat.
Topics: Animals; Body Weight; Drinking; Eating; Female; Kidney; Methylnitrosourea; Neoplasms, Experimental; | 1980 |
Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with n-butyl-n-(4-hydroxybutyl)nitrosamine.
Topics: Animals; Butylhydroxybutylnitrosamine; Caffeine; Cocarcinogenesis; Male; Microscopy, Electron; Neopl | 1980 |
The meaning of risk assessment.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Allowable | 1980 |
Effect of sodium saccharin and L-tryptophan on rat urine during bladder carcinogenesis.
Topics: Animals; Blood Glucose; FANFT; Glycosuria; Natriuresis; Neoplasms, Experimental; Rats; Saccharin; Tr | 1981 |
Sequencing analysis of Ha-, Ki-, and N-ras genes in rat urinary bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium saccharin.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Transitional Cell; Codon; DNA Primers; DNA, | 1993 |
Lack of induction of epithelial cell proliferation by sodium saccharin and sodium L-ascorbate in the urinary bladder of NCI-black-Reiter (NBR) male rats.
Topics: Animals; Ascorbic Acid; Body Weight; Carcinogens; Cell Division; DNA; Epithelial Cells; Epithelium; | 1994 |
Study of sodium saccharin co-carcinogenicity in the rat.
Topics: Animals; Carcinogenicity Tests; Carcinoma, Transitional Cell; Cocarcinogenesis; Dose-Response Relati | 1994 |
Associations between bladder cancer risk factors and tumor stage and grade at diagnosis.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Coffee; Educational Status; Female; Humans; Ma | 1994 |
Analysis of differentiation-associated proteins in rat bladder carcinogenesis.
Topics: Animals; FANFT; Male; Membrane Glycoproteins; Membrane Proteins; Rats; Rats, Inbred F344; Saccharin; | 1996 |
Alteration of intercellular communication in a human urothelial carcinoma cell-line by tumor-promoting agents.
Topics: Adult; Anticonvulsants; Antioxidants; Butylated Hydroxyanisole; Carcinogens; Carcinoma, Transitional | 1996 |
"Report of the Rodent Bladder Carcinogenesis Working Group".
Topics: Animals; Chelating Agents; Nitrilotriacetic Acid; Rodentia; Saccharin; Urinary Bladder Neoplasms | 1997 |
Is saccharin safe? Animal testing revisited.
Topics: Animals; Carcinogens; Haplorhini; Saccharin; Urinary Bladder Neoplasms; Urine; Urothelium | 1998 |
Can the concept of hormesis Be generalized to carcinogenesis?
Topics: Animals; Caffeic Acids; Carcinogenicity Tests; Carcinogens; Cell Division; Dioxins; DNA Ligases; Dos | 1998 |
Toward a sane national policy on food safety.
Topics: Carcinogens; Evaluation Studies as Topic; Food; Food Additives; Humans; Public Policy; Saccharin; Sa | 1980 |
The saccharin ban.
Topics: Animals; Female; Legislation, Drug; Male; Public Opinion; Rats; Saccharin; United States; United Sta | 1977 |
Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats.
Topics: Animals; Ascorbic Acid; Calcium Phosphates; Chemical Precipitation; Dose-Response Relationship, Drug | 2000 |
What's the truth about the health risks of sugar substitutes such as saccharin and aspartame?
Topics: Animals; Aspartame; Headache; Humans; Rats; Saccharin; Urinary Bladder Neoplasms | 2001 |
The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats.
Topics: Administration, Oral; Aminobiphenyl Compounds; Animals; Animals, Genetically Modified; Carcinogens; | 2001 |
Response of the rat to saccharin with particular reference to the urinary bladder.
Topics: Animals; Body Weight; Drug Administration Schedule; Female; Hydrogen-Ion Concentration; Male; Rats; | 1979 |
Artificial sweeteners and human bladder cancer.
Topics: British Columbia; Cyclamates; Diet Surveys; Dose-Response Relationship, Drug; Female; Humans; Male; | 1977 |
Bladder cancer and saccharin.
Topics: Canada; Diet Surveys; Female; Humans; Male; Risk; Saccharin; Urinary Bladder Neoplasms | 1977 |
Saccharin: the problem with sucrose substitutes.
Topics: Animals; Cyclamates; Haplorhini; Humans; Legislation, Drug; Rats; Saccharin; Sweetening Agents; Unit | 1979 |
Long-term safety evaluation and metabolism of o-benzoic sulfimide (saccharin) in rhesus monkeys.
Topics: Animals; Body Weight; Female; Haplorhini; Kidney; Liver; Macaca mulatta; Male; Saccharin; Testis; Ur | 1978 |
Use of artificial sweeteners by cancer patients.
Topics: Aged; Cyclamates; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Neoplasms; Saccharin; Sw | 1979 |
Sour grapes over saccharin.
Topics: Animals; Female; History, 19th Century; History, 20th Century; Humans; Legislation, Drug; Male; Rats | 1977 |
Saccharin: an epigenetic carcinogen/mutagen?
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA, Neoplasm; Genotype; Mutagens; Saccharin; | 1978 |
Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis.
Topics: Animals; Epithelium; FANFT; Male; Microscopy, Electron, Scanning; Microvilli; Neoplasms, Experimenta | 1979 |
Sugar substitutes.
Topics: Animals; Aspartame; Cricetinae; Cyclamates; Humans; Male; Mice; Neoplasms, Experimental; Rats; Sacch | 1979 |
The saccharin question re-examined: an A.D.A. Statement.
Topics: Animals; Dietetics; Female; Humans; Legislation, Food; Male; Rats; Saccharin; Societies, Scientific; | 1979 |
Saccharin, the FDA, the NHC and the ACSH.
Topics: Animals; Humans; Male; Rats; Saccharin; United States; United States Food and Drug Administration; U | 1979 |
Urinary bladder carcinogenesis: initiation-promotion.
Topics: Animals; Cocarcinogenesis; FANFT; Humans; Neoplasms, Experimental; Rats; Saccharin; Schistosomiasis; | 1979 |
Comparison of studies on saccharin and sodium nitrite.
Topics: Animals; Drug Contamination; Female; Male; Mononuclear Phagocyte System; Nitrites; Rats; Research De | 1979 |
[Saccharin and bladder carcinoma].
Topics: Animals; Cyclamates; Dose-Response Relationship, Drug; Drug Contamination; Humans; Prognosis; Rats; | 1978 |
Saccharin, cyclamate, and human bladder cancer. No evidence of an association.
Topics: Cyclamates; Female; Humans; Legislation, Drug; Male; Risk; Saccharin; Sex Factors; Smoking; United S | 1978 |
Possible role of saccharin in the development of bladder cancer: a review.
Topics: Animals; Female; Humans; Mice; Rats; Saccharin; Urinary Bladder Neoplasms | 1978 |
Saccharin and cyclamate.
Topics: Cyclamates; Humans; Saccharin; Urinary Bladder Neoplasms | 1978 |
[Is the use of saccharin really dangerous?].
Topics: Animals; Carcinogens; Humans; Rats; Risk; Saccharin; Urinary Bladder Neoplasms | 1978 |
Saccharin and bladder cancer.
Topics: Animals; Female; Humans; Male; Rats; Risk; Saccharin; Urinary Bladder Neoplasms | 1979 |
Saccharin: from carcinogen to promoter.
Topics: Animals; Biotransformation; Cocarcinogenesis; Neoplasms, Experimental; Saccharin; Urinary Bladder Ne | 1979 |
Delaney's here again.
Topics: Animals; Humans; Legislation, Drug; Saccharin; United States; Urinary Bladder Neoplasms | 1977 |
Saccharin ban will not be total.
Topics: Animals; Canada; Female; Humans; Legislation, Drug; Male; Rats; Saccharin; Urinary Bladder Neoplasms | 1977 |
Saccharin--the bitter sweet.
Topics: Animals; Disease Models, Animal; Female; Humans; In Vitro Techniques; Legislation, Drug; Male; Rats; | 1977 |
The banning of saccharin.
Topics: Animals; Humans; Legislation, Drug; Rats; Saccharin; United States; Urinary Bladder Neoplasms | 1977 |
The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.
Topics: 2-Naphthylamine; Animals; Carcinogens; Carcinogens, Environmental; Carcinoma, Transitional Cell; Cyc | 1977 |
Recommendations for modifying Federal statutes relating to enviromental carcinogens.
Topics: Carcinogens; Diabetes Complications; Female; Humans; Legislation, Medical; Male; Saccharin; United S | 1977 |
Saccharin and chemical carcinogenesis.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Epidemiologic Methods; Female; Humans; Male; | 1977 |
Cyclamates and saccharin.
Topics: Animals; Chick Embryo; Cyclamates; Drug and Narcotic Control; Humans; Rats; Saccharin; South Africa; | 1977 |
FDRL investigation of cyclamates.
Topics: Animals; Carcinoma, Papillary; Cyclamates; Cyclohexylamines; Female; Male; Mice; Rats; Saccharin; Un | 1975 |
Synthetic sweetners: cyclamates, saccharin, aspartame.
Topics: Animals; Aspartame; Aspartic Acid; Beverages; Cyclamates; Cyclohexylamines; Diet, Reducing; Dipeptid | 1975 |
A carcinogenicity study of commercial saccharin in the rat.
Topics: Animals; Body Weight; Carcinogens; Female; Male; Papilloma; Rats; Rats, Inbred Strains; Saccharin; S | 1975 |
Chronic toxicity study of cyclamate: saccharin (10: 1) in rats.
Topics: Animals; Behavior, Animal; Body Weight; Cyclamates; Cyclohexylamines; Diet; Drug Combinations; Femal | 1975 |
Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide.
Topics: Administration, Oral; Animals; Carcinogens; Cyclamates; Cyclophosphamide; Dose-Response Relationship | 1975 |
Editorial: Saccharin and bladder cancer.
Topics: Diabetes Complications; Humans; Lung Neoplasms; Saccharin; Smoking; Urinary Bladder Neoplasms | 1975 |
Assessment of the carcinogenicity of non-nutritive sweeteners I: Saccharin.
Topics: Animals; Carcinogens; Mice; Rats; Saccharin; Species Specificity; Urinary Bladder Neoplasms | 1975 |
Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits.
Topics: Adolescent; Adult; Aged; Diabetes Complications; England; Female; Humans; Lung Neoplasms; Male; Midd | 1975 |
A chronic study of artificial sweeteners in Syrian golden hamsters.
Topics: Animals; Carcinogens; Cricetinae; Cyclamates; Drug Administration Schedule; Female; Male; Neoplasms, | 1975 |
[Etiology and pathogenesis of bladder cancer].
Topics: 2-Naphthylamine; Amines; Animals; Carcinogens; Cyclamates; DNA; Dogs; Humans; Mice; Saccharin; Urina | 1976 |
Anti-promoting effect of nordihydroguaiaretic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine and sodium saccharin-induced rat urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Hyperplasia; Male; Masoprocol; Papilloma; Rats; Rats, Inbred | 1992 |
Direct DNA sequencing of the rat neu oncogene transmembrane domain reveals no mutation in urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-methyl-N-nitrosourea.
Topics: Amino Acid Sequence; Animals; Base Sequence; Butylhydroxybutylnitrosamine; DNA, Neoplasm; FANFT; Mal | 1991 |
Lack of bladder carcinogenicity of dietary sodium saccharin in analbuminaemic rats, which are highly susceptible to N-nitroso-n-butyl-(4-hydroxybutyl)amine.
Topics: Administration, Oral; Animals; Body Weight; Butylhydroxybutylnitrosamine; Disease Susceptibility; Hy | 1991 |
Inhibitory effect of 2-O-octadecylascorbic acid in agglutination assay with concanavalin A; short-term examination of rat urinary bladder carcinogenesis.
Topics: Agglutination Tests; Animals; Ascorbic Acid; Butylhydroxybutylnitrosamine; Cell Aggregation; Concana | 1991 |
Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. II. Dose response and reversibility.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Female; Folic Acid; Liver; Male; Nutritional | 1991 |
Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats.
Topics: Animals; Ascorbic Acid; Body Weight; Butylhydroxybutylnitrosamine; Calcium Carbonate; Diet; Drinking | 1991 |
Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet.
Topics: Animals; Carcinoma; Drinking; Drug Evaluation, Preclinical; FANFT; Hyperplasia; Male; Papilloma; Rat | 1991 |
In vitro transformation of rat bladder epithelium by 2-amino-4-(5-nitro-2-furyl)thiazole.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Drug Synergism; Epithelial C | 1991 |
H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.
Topics: Animals; Ascorbic Acid; Base Sequence; Blotting, Western; Carcinogens; Carcinoma; Carcinoma, Transit | 1991 |
Evaluation of nitrofurantoin on the two stages of urinary bladder carcinogenesis in the rat.
Topics: Administration, Oral; Animals; Autoradiography; Benzidines; Body Weight; Cocarcinogenesis; FANFT; Ma | 1990 |
Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis.
Topics: Animals; Ascorbic Acid; Drug Synergism; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Sacc | 1990 |
Saccharin/cyclamates; laboratory evidence.
Topics: Animals; Cyclamates; Female; Male; Rats; Saccharin; Urinary Bladder Neoplasms | 1985 |
Saccharin/cyclamates: epidemiological evidence.
Topics: Cyclamates; Female; Humans; Male; Risk; Saccharin; Smoking; Urinary Bladder Neoplasms | 1985 |
Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate.
Topics: Animals; Cyclamates; Epithelium; Female; Hyperplasia; Methylnitrosourea; Microscopy, Electron, Scann | 1986 |
Effects of treatment with N-methyl-N-nitrosourea, artificial sweeteners, and cyclophosphamide on adult rat urinary bladder in vitro.
Topics: Animals; Cyclamates; Cyclophosphamide; Epithelium; Female; Hyperplasia; Methylnitrosourea; Microscop | 1987 |
Rapid screening of potential human bladder carcinogens: genotoxicity in meiosis repair deficient Drosophila melanogaster.
Topics: Animals; Carcinogenicity Tests; Coffee; Cyclophosphamide; DNA Damage; DNA Repair; Drosophila melanog | 1989 |
NIEHS training in environmental toxicology.
Topics: Animals; Education, Medical, Continuing; Environmental Exposure; Humans; Male; National Institutes o | 1989 |
Changes in the urine and scanning electron microscopically observed appearance of the rat bladder following treatment with tumor promoters.
Topics: Animals; Antioxidants; Biphenyl Compounds; Crystallization; Hydrogen-Ion Concentration; Male; Micros | 1986 |
Validity of short-term examination for antipromoters of bladder carcinogenesis.
Topics: Agglutination; Animals; Antioxidants; Eflornithine; Male; Prostaglandin Antagonists; Rats; Rats, Inb | 1988 |
Effects of retinoids and inhibitors of arachidonic acid metabolism on tumor-promoter-induced soft agar colony formation of mouse epidermal cells and rat urinary bladder cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Colony-Forming Units Assay; Diterpenes; Epidermis; Fem | 1988 |
Saccharin and aspartame: are they safe to consume during pregnancy?
Topics: Adult; Animals; Aspartame; Dipeptides; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy | 1988 |
Estimates of the risk of bladder tumor promotion by saccharin in rats.
Topics: Animals; Rats; Risk Factors; Saccharin; United States; Urinary Bladder Neoplasms | 1988 |
Dose-response relationships in rodents of promoter carcinogens: a tentative interpretation of some downward trends.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Models, Theoretical; Rats; Rats, Inbred Stra | 1988 |
A cellular dynamics model of experimental bladder cancer: analysis of the effect of sodium saccharin in the rat.
Topics: Animals; Cell Survival; Cocarcinogenesis; Computer Simulation; FANFT; Mitosis; Models, Biological; N | 1988 |
Sugar and sugar substitutes. Comparisons and indications.
Topics: Animals; Aspartame; Diet, Diabetic; Diet, Reducing; Dietary Carbohydrates; Energy Intake; Humans; Ra | 1987 |
Bladder cancer and the consumption of alcoholic beverages in Spain.
Topics: Age Factors; Aged; Alcohol Drinking; Carcinoma, Transitional Cell; Cyclamates; Epidemiologic Methods | 1987 |
Tobacco smoking, occupational exposure and bladder cancer in Argentina.
Topics: Age Factors; Argentina; Beverages; Carcinoma; Environmental Exposure; Female; Humans; Male; Occupati | 1987 |
Saccharin. Review of safety issues. AMA Council on Scientific Affairs.
Topics: Animals; Food Additives; Male; Rats; Risk; Saccharin; Urinary Bladder Neoplasms | 1986 |
Saccharin: past, present, and future.
Topics: Animals; Chemical Phenomena; Chemistry; Cocarcinogenesis; Humans; Rats; Risk; Saccharin; Urinary Bla | 1986 |
Urinary excretion of orally administered oxalic acid in saccharin and o-phenylphenol-fed NMRI mice.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Male; Mice; Mice, Inbred Strains; Oxalates; Oxali | 1986 |
Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogenesis in male F344 rats.
Topics: Animals; Aspirin; Body Weight; Cocarcinogenesis; FANFT; Hydrogen-Ion Concentration; Male; Rats; Rats | 1986 |
In utero-exposure to saccharin: a threat?
Topics: Adult; Female; Fetal Blood; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Sacc | 1986 |
Effect of sodium phenobarbital and sodium saccharin in AIN-76A diet on carcinogenesis initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and N,N-dibutylnitrosamine in male F344 rats.
Topics: Animals; Esophageal Neoplasms; FANFT; Hydrogen-Ion Concentration; Liver Neoplasms, Experimental; Mal | 1986 |
The effects of saccharin on the development of neoplastic lesions initiated with N-methyl-N-nitrosourea in the rat urothelium.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Epithelium; Female; Methylnitrosourea; Rats; | 1986 |
Saccharin. Review of safety issues. Council on Scientific Affairs.
Topics: American Medical Association; Animals; Child; Cricetinae; Female; Haplorhini; Humans; Male; Mice; Pr | 1985 |
[Epidemiology of bladder cancers].
Topics: Aged; Caffeine; Carcinogens; Female; France; Humans; Male; Middle Aged; Neoplasms, Radiation-Induced | 1985 |
Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Freezing; Hyperplasia; Male; Rats; Rats, In | 1985 |
[Etiology of bladder cancer].
Topics: Animals; Cholesterol; Coffee; Cyclamates; Food Additives; Humans; Insecticides; Metals; Nitrosamines | 1985 |
Morphologic changes in the urinary bladder and stomach after long-term administration of sodium saccharin in F344 rats.
Topics: Animals; Male; Rats; Rats, Inbred F344; Saccharin; Stomach; Stomach Neoplasms; Urinary Bladder; Urin | 1985 |
[The cancer-risk in man from synthetic sweetening agents].
Topics: Animals; Carcinoma, Hepatocellular; Cyclamates; Female; Liver Neoplasms; Lung Neoplasms; Lymphoma, N | 1971 |
Bladder cancer mortality in England and Wales in relation to cigarette smoking and saccharin consumption.
Topics: Adult; Aged; Cyclamates; England; Female; Humans; Male; Middle Aged; Saccharin; Smoking; Urinary Bla | 1974 |
Editorial: Safety of saccharin--the present status.
Topics: Animals; Humans; Rats; Saccharin; United States; United States Food and Drug Administration; Urinary | 1974 |
Letter: Co-carcinogenic action of saccharin in the chemical induction of bladder cancer.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Female; Hyperplasia; N | 1973 |
Saccharin in the balance.
Topics: Animals; Cyclamates; Humans; Legislation, Drug; Lymphoma, Non-Hodgkin; Mice; Rats; Saccharin; United | 1973 |
Impurities in saccharin and bladder cancer.
Topics: Animals; Carcinogens; Drug Synergism; Female; Nitrosourea Compounds; Rats; Saccharin; Urinary Bladde | 1973 |
Saccharin--a European assessment: A report.
Topics: Animals; Carcinogens; Europe; Humans; Legislation, Drug; Rats; Saccharin; United States; Urinary Bla | 1973 |
Proceedings: Histology of tumour formation in the bladder of rats receiving dietary saccharin and a single dose of N-methyl N-nitrosourea.
Topics: Animals; Diet; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Saccharin; Urinary Bladder Neop | 1974 |
Letter: Saccharin and carcinoma of the bladder.
Topics: Humans; Saccharin; Time Factors; Urinary Bladder Neoplasms | 1974 |
[Toxicology of chemical sweetening agents].
Topics: Abnormalities, Drug-Induced; Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver I | 1971 |
Some sweetness left.
Topics: Academies and Institutes; Animals; Benzoates; Cyclamates; Foodborne Diseases; Lung Neoplasms; Mice; | 1970 |
Production of urinary bladder carcinomas in mice by sodium saccharin.
Topics: Animals; Carcinoma, Squamous Cell; Cholesterol; Mice; Saccharin; Sweetening Agents; Thiazoles; Time | 1970 |